Engagement of Toll-like receptor 2 in mouse macrophages infected with Mycobacterium avium induces non-oxidative and TNF-independent anti-mycobacterial activity

Toll-like receptor (TLR) 2 plays an important role in the immune response to mycobacterial infections, being required for optimal immunity against certain virulent Mycobacterium avium strains. Here we analyzed the role of TLR2 in the intra-macrophagic growth of M. avium, using macrophages from TLR2-...

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Veröffentlicht in:	European journal of immunology 2008-08, Vol.38 (8), p.2180-2189
Hauptverfasser:	Gomes, M. Salomé, Sousa Fernandes, Sofia, Cordeiro, João V, Silva Gomes, Sandro, Vieira, André, Appelberg, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Immunity Macrophages - immunology Macrophages - microbiology Mice Mice, Inbred C57BL Mycobacterium avium - immunology Myeloid Differentiation Factor 88 - physiology Nitric oxide Nitric Oxide - physiology Phagocytes Superoxides - metabolism Toll-Like Receptor 2 - agonists Toll-Like Receptor 2 - physiology Toll-Like Receptor 6 - physiology Tumor Necrosis Factor-alpha - physiology
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