Serum Retinol Concentrations in Hospitalized Severe Protein-energy Malnourished Children
Background: Vitamin A deficiency (VAD) is a major nutritional problem in many developing countries. Vitamin A status has been reported to be adversely affected in protein-energy malnutrition (PEM). Objective: to assess and compare serum retinol concentrations in hospitalized children with severe PEM...
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| Veröffentlicht in: | Journal of tropical pediatrics (1980) 2008-08, Vol.54 (4), p.248-252 |
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| creator | de Fátima Costa Caminha, Maria da Silva Diniz, Alcides Falbo, Ana Rodrigues de Arruda, Ilma Kruze Grande Serva, Vilneide Braga de Albuquerque, Luciano Lira de Freitas Lola, Margarida Maria Ebrahim, G. J. |
| description | Background: Vitamin A deficiency (VAD) is a major nutritional problem in many developing countries. Vitamin A status has been reported to be adversely affected in protein-energy malnutrition (PEM). Objective: to assess and compare serum retinol concentrations in hospitalized children with severe PEM and normal ones. Methods: a prospective series of 34 malnourished and 29 normal control children, 0.05), maternal schooling (p > 0.05), family income (p > 0.05), breastfeeding practice (p > 0.05) and residence (p > 0.05). However, malnourished children with diarrhoea showed lower serum retinol concentrations (p = 0.021) compared to those without diarrhoea. Conclusion: VAD was prevalent in hospitalized children with severe PEM and also among normal ones although in lesser magnitude. Intervention for prevention and control of deficiency of vitamin A are recommended in settings where diarrhea is endemic and there are unfavorable socio-economical conditions. |
| doi_str_mv | 10.1093/tropej/fmn018 |
| format | Article |
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J.</creator><creatorcontrib>de Fátima Costa Caminha, Maria ; da Silva Diniz, Alcides ; Falbo, Ana Rodrigues ; de Arruda, Ilma Kruze Grande ; Serva, Vilneide Braga ; de Albuquerque, Luciano Lira ; de Freitas Lola, Margarida Maria ; Ebrahim, G. J.</creatorcontrib><description>Background: Vitamin A deficiency (VAD) is a major nutritional problem in many developing countries. Vitamin A status has been reported to be adversely affected in protein-energy malnutrition (PEM). Objective: to assess and compare serum retinol concentrations in hospitalized children with severe PEM and normal ones. Methods: a prospective series of 34 malnourished and 29 normal control children, <60 months old, hospitalized at IMIP, Recife-PE were recruited for the study between August 2004 and May 2005. Serum retinol level was assayed by high performance liquid chromatography and concentrations adjusted for presence of inflammation as evidenced by levels of C-reactive protein. Blood retinol level was compared according to nutritional status (severe PEM versus normal), gender, age, maternal schooling, family income, breastfeeding practice, residence and perceived morbidity. Results: the prevalence of low serum retinol (<0.70 μmol l−1) was 41.2% in children with severe PEM and 24.1% in normal children. Serum retinol concentrations were lower in children whose mothers had low schooling (p = 0.025) and families with low per capita income (p = 0.049), regardless of their nutritional status. Serum retinol concentrations had similar distribution between children with severe PEM and normal, when adjusted for gender (p > 0.05), age (p > 0.05), maternal schooling (p > 0.05), family income (p > 0.05), breastfeeding practice (p > 0.05) and residence (p > 0.05). However, malnourished children with diarrhoea showed lower serum retinol concentrations (p = 0.021) compared to those without diarrhoea. Conclusion: VAD was prevalent in hospitalized children with severe PEM and also among normal ones although in lesser magnitude. Intervention for prevention and control of deficiency of vitamin A are recommended in settings where diarrhea is endemic and there are unfavorable socio-economical conditions.</description><identifier>ISSN: 0142-6338</identifier><identifier>EISSN: 1465-3664</identifier><identifier>DOI: 10.1093/tropej/fmn018</identifier><identifier>PMID: 18385151</identifier><identifier>CODEN: JTRPAO</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Biological and medical sciences ; Brazil ; Child, Preschool ; Chromatography, High Pressure Liquid ; Female ; General aspects ; Hospitalization ; Humans ; Infant ; Male ; Medical sciences ; Metabolic diseases ; Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) ; Protein-Energy Malnutrition - blood ; Vitamin A - blood ; Vitamin A Deficiency - blood ; Vitamins - blood</subject><ispartof>Journal of tropical pediatrics (1980), 2008-08, Vol.54 (4), p.248-252</ispartof><rights>The Author [2008]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org 2008</rights><rights>2008 INIST-CNRS</rights><rights>The Author [2008]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-706d0300a7549a8f7b15d32241099672785524034ee53ab233e8e5e48ff51183</citedby><cites>FETCH-LOGICAL-c458t-706d0300a7549a8f7b15d32241099672785524034ee53ab233e8e5e48ff51183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20588959$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18385151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Fátima Costa Caminha, Maria</creatorcontrib><creatorcontrib>da Silva Diniz, Alcides</creatorcontrib><creatorcontrib>Falbo, Ana Rodrigues</creatorcontrib><creatorcontrib>de Arruda, Ilma Kruze Grande</creatorcontrib><creatorcontrib>Serva, Vilneide Braga</creatorcontrib><creatorcontrib>de Albuquerque, Luciano Lira</creatorcontrib><creatorcontrib>de Freitas Lola, Margarida Maria</creatorcontrib><creatorcontrib>Ebrahim, G. J.</creatorcontrib><title>Serum Retinol Concentrations in Hospitalized Severe Protein-energy Malnourished Children</title><title>Journal of tropical pediatrics (1980)</title><addtitle>J Trop Pediatr</addtitle><description>Background: Vitamin A deficiency (VAD) is a major nutritional problem in many developing countries. Vitamin A status has been reported to be adversely affected in protein-energy malnutrition (PEM). Objective: to assess and compare serum retinol concentrations in hospitalized children with severe PEM and normal ones. Methods: a prospective series of 34 malnourished and 29 normal control children, <60 months old, hospitalized at IMIP, Recife-PE were recruited for the study between August 2004 and May 2005. Serum retinol level was assayed by high performance liquid chromatography and concentrations adjusted for presence of inflammation as evidenced by levels of C-reactive protein. Blood retinol level was compared according to nutritional status (severe PEM versus normal), gender, age, maternal schooling, family income, breastfeeding practice, residence and perceived morbidity. Results: the prevalence of low serum retinol (<0.70 μmol l−1) was 41.2% in children with severe PEM and 24.1% in normal children. Serum retinol concentrations were lower in children whose mothers had low schooling (p = 0.025) and families with low per capita income (p = 0.049), regardless of their nutritional status. Serum retinol concentrations had similar distribution between children with severe PEM and normal, when adjusted for gender (p > 0.05), age (p > 0.05), maternal schooling (p > 0.05), family income (p > 0.05), breastfeeding practice (p > 0.05) and residence (p > 0.05). However, malnourished children with diarrhoea showed lower serum retinol concentrations (p = 0.021) compared to those without diarrhoea. Conclusion: VAD was prevalent in hospitalized children with severe PEM and also among normal ones although in lesser magnitude. Intervention for prevention and control of deficiency of vitamin A are recommended in settings where diarrhea is endemic and there are unfavorable socio-economical conditions.</description><subject>Biological and medical sciences</subject><subject>Brazil</subject><subject>Child, Preschool</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Female</subject><subject>General aspects</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</subject><subject>Protein-Energy Malnutrition - blood</subject><subject>Vitamin A - blood</subject><subject>Vitamin A Deficiency - blood</subject><subject>Vitamins - blood</subject><issn>0142-6338</issn><issn>1465-3664</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1v1DAQBmALgei2cOSKIiQqLqH-jJ1jtQss0lYg2kPFxfImE-olsYPtIMqvx6tEReLCaS6PZt55EXpB8FuCa3aRgh_hcNENDhP1CK0Ir0TJqoo_RitMOC0rxtQJOo3xgDGmivOn6IQopgQRZIVuryFMQ_EFknW-L9beNeBSMMl6Fwvriq2Po02mt7-hLa7hJwQoPgefwLoSHIRv98WV6Z2fgo13mazvbN8GcM_Qk870EZ4v8wzdvH93s96Wu08fPq4vd2XDhUqlxFWLGcZGCl4b1ck9ES2jlOfn6kpSqYSgHDMOIJjZU8ZAgQCuuk6Q_MYZOp_XjsH_mCAmPdjYQN8bB36KuqqZYELKDF_9Aw85s8vRdL52RPSIyhk1wccYoNNjsIMJ95pgfaxbz3Xrue7sXy5Lp_0A7V-99JvB6wWY2Ji-C8Y1Nj44ioVStaizezM7P43_vblktDHBrwdswnddSSaF3t5-1XKrNpur3UbX7A9cxKZE</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>de Fátima Costa Caminha, Maria</creator><creator>da Silva Diniz, Alcides</creator><creator>Falbo, Ana Rodrigues</creator><creator>de Arruda, Ilma Kruze Grande</creator><creator>Serva, Vilneide Braga</creator><creator>de Albuquerque, Luciano Lira</creator><creator>de Freitas Lola, Margarida Maria</creator><creator>Ebrahim, G. J.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20080801</creationdate><title>Serum Retinol Concentrations in Hospitalized Severe Protein-energy Malnourished Children</title><author>de Fátima Costa Caminha, Maria ; da Silva Diniz, Alcides ; Falbo, Ana Rodrigues ; de Arruda, Ilma Kruze Grande ; Serva, Vilneide Braga ; de Albuquerque, Luciano Lira ; de Freitas Lola, Margarida Maria ; Ebrahim, G. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-706d0300a7549a8f7b15d32241099672785524034ee53ab233e8e5e48ff51183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Brazil</topic><topic>Child, Preschool</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Female</topic><topic>General aspects</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</topic><topic>Protein-Energy Malnutrition - blood</topic><topic>Vitamin A - blood</topic><topic>Vitamin A Deficiency - blood</topic><topic>Vitamins - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Fátima Costa Caminha, Maria</creatorcontrib><creatorcontrib>da Silva Diniz, Alcides</creatorcontrib><creatorcontrib>Falbo, Ana Rodrigues</creatorcontrib><creatorcontrib>de Arruda, Ilma Kruze Grande</creatorcontrib><creatorcontrib>Serva, Vilneide Braga</creatorcontrib><creatorcontrib>de Albuquerque, Luciano Lira</creatorcontrib><creatorcontrib>de Freitas Lola, Margarida Maria</creatorcontrib><creatorcontrib>Ebrahim, G. J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of tropical pediatrics (1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Fátima Costa Caminha, Maria</au><au>da Silva Diniz, Alcides</au><au>Falbo, Ana Rodrigues</au><au>de Arruda, Ilma Kruze Grande</au><au>Serva, Vilneide Braga</au><au>de Albuquerque, Luciano Lira</au><au>de Freitas Lola, Margarida Maria</au><au>Ebrahim, G. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Retinol Concentrations in Hospitalized Severe Protein-energy Malnourished Children</atitle><jtitle>Journal of tropical pediatrics (1980)</jtitle><addtitle>J Trop Pediatr</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>54</volume><issue>4</issue><spage>248</spage><epage>252</epage><pages>248-252</pages><issn>0142-6338</issn><eissn>1465-3664</eissn><coden>JTRPAO</coden><abstract>Background: Vitamin A deficiency (VAD) is a major nutritional problem in many developing countries. Vitamin A status has been reported to be adversely affected in protein-energy malnutrition (PEM). Objective: to assess and compare serum retinol concentrations in hospitalized children with severe PEM and normal ones. Methods: a prospective series of 34 malnourished and 29 normal control children, <60 months old, hospitalized at IMIP, Recife-PE were recruited for the study between August 2004 and May 2005. Serum retinol level was assayed by high performance liquid chromatography and concentrations adjusted for presence of inflammation as evidenced by levels of C-reactive protein. Blood retinol level was compared according to nutritional status (severe PEM versus normal), gender, age, maternal schooling, family income, breastfeeding practice, residence and perceived morbidity. Results: the prevalence of low serum retinol (<0.70 μmol l−1) was 41.2% in children with severe PEM and 24.1% in normal children. Serum retinol concentrations were lower in children whose mothers had low schooling (p = 0.025) and families with low per capita income (p = 0.049), regardless of their nutritional status. Serum retinol concentrations had similar distribution between children with severe PEM and normal, when adjusted for gender (p > 0.05), age (p > 0.05), maternal schooling (p > 0.05), family income (p > 0.05), breastfeeding practice (p > 0.05) and residence (p > 0.05). However, malnourished children with diarrhoea showed lower serum retinol concentrations (p = 0.021) compared to those without diarrhoea. Conclusion: VAD was prevalent in hospitalized children with severe PEM and also among normal ones although in lesser magnitude. Intervention for prevention and control of deficiency of vitamin A are recommended in settings where diarrhea is endemic and there are unfavorable socio-economical conditions.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>18385151</pmid><doi>10.1093/tropej/fmn018</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of tropical pediatrics (1980), 2008-08, Vol.54 (4), p.248-252 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Biological and medical sciences Brazil Child, Preschool Chromatography, High Pressure Liquid Female General aspects Hospitalization Humans Infant Male Medical sciences Metabolic diseases Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Protein-Energy Malnutrition - blood Vitamin A - blood Vitamin A Deficiency - blood Vitamins - blood |
| title | Serum Retinol Concentrations in Hospitalized Severe Protein-energy Malnourished Children |
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