GSTM1, smoking and lung cancer : a case-control study
We conducted a case-control study to examine the risk of lung cancer in relation to GSTM1 polymorphism and cigarette smoking (primarily of black tobacco) in a French population. The 611 subjects were 301 incident lung cancer cases and 310 hospital controls. We were able to constitute a DNA bank for...
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| Veröffentlicht in: | International journal of epidemiology 1999-10, Vol.28 (5), p.829-835 |
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| container_title | International journal of epidemiology |
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| creator | STÜCKER, I DE WAZIERS, I CENEE, S BIGNON, J DEPIERRE, A MILLERON, B BEAUNE, P HEMON, D |
| description | We conducted a case-control study to examine the risk of lung cancer in relation to GSTM1 polymorphism and cigarette smoking (primarily of black tobacco) in a French population.
The 611 subjects were 301 incident lung cancer cases and 310 hospital controls. We were able to constitute a DNA bank for 547 subjects (89.5%) and gather detailed information on smoking history for all of them. Results presented here concern 247 cases and 254 controls.
Taking non- or light smokers as the reference category, we estimated odds ratios (OR) of 4.2 (95% CI: 2.6-6.7) and 5.2 (95% CI: 3.3-8.3) for the medium and heavy smokers respectively. On the other hand we estimated that the crude OR associating GSTM1 with lung cancer was 1.3 (95% CI: 0.9-1.8). Furthermore our data do not depart significantly from a multiplicative model of the combined effects of smoking and GSTM1 deficiency.
We conclude that smoking and the GSTM1 gene are each a risk factor for lung cancer, and that their combined effect does not differ significantly from that of a multiplicative model. |
| doi_str_mv | 10.1093/ije/28.5.829 |
| format | Article |
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The 611 subjects were 301 incident lung cancer cases and 310 hospital controls. We were able to constitute a DNA bank for 547 subjects (89.5%) and gather detailed information on smoking history for all of them. Results presented here concern 247 cases and 254 controls.
Taking non- or light smokers as the reference category, we estimated odds ratios (OR) of 4.2 (95% CI: 2.6-6.7) and 5.2 (95% CI: 3.3-8.3) for the medium and heavy smokers respectively. On the other hand we estimated that the crude OR associating GSTM1 with lung cancer was 1.3 (95% CI: 0.9-1.8). Furthermore our data do not depart significantly from a multiplicative model of the combined effects of smoking and GSTM1 deficiency.
We conclude that smoking and the GSTM1 gene are each a risk factor for lung cancer, and that their combined effect does not differ significantly from that of a multiplicative model.</description><identifier>ISSN: 0300-5771</identifier><identifier>EISSN: 1464-3685</identifier><identifier>DOI: 10.1093/ije/28.5.829</identifier><identifier>PMID: 10597978</identifier><identifier>CODEN: IJEPBF</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Age Distribution ; Aged ; Analysis of Variance ; Biological and medical sciences ; Case-Control Studies ; Confidence Intervals ; Female ; France - epidemiology ; Genetic Predisposition to Disease - epidemiology ; Glutathione Transferase - genetics ; Glutathione Transferase - metabolism ; Health Surveys ; Humans ; Incidence ; Lung Neoplasms - epidemiology ; Lung Neoplasms - genetics ; Male ; Medical sciences ; Middle Aged ; Odds Ratio ; Pneumology ; Polymorphism, Genetic ; Reference Values ; Risk Assessment ; Risk Factors ; Sampling Studies ; Smoking - adverse effects ; Smoking - epidemiology ; Tumors of the respiratory system and mediastinum</subject><ispartof>International journal of epidemiology, 1999-10, Vol.28 (5), p.829-835</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Oct 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-f813a185480564e70a2b994c74a4c847186ca641d38f3ca1f8c1dc9f3c2f2a33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1984770$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10597978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>STÜCKER, I</creatorcontrib><creatorcontrib>DE WAZIERS, I</creatorcontrib><creatorcontrib>CENEE, S</creatorcontrib><creatorcontrib>BIGNON, J</creatorcontrib><creatorcontrib>DEPIERRE, A</creatorcontrib><creatorcontrib>MILLERON, B</creatorcontrib><creatorcontrib>BEAUNE, P</creatorcontrib><creatorcontrib>HEMON, D</creatorcontrib><title>GSTM1, smoking and lung cancer : a case-control study</title><title>International journal of epidemiology</title><addtitle>Int J Epidemiol</addtitle><description>We conducted a case-control study to examine the risk of lung cancer in relation to GSTM1 polymorphism and cigarette smoking (primarily of black tobacco) in a French population.
The 611 subjects were 301 incident lung cancer cases and 310 hospital controls. We were able to constitute a DNA bank for 547 subjects (89.5%) and gather detailed information on smoking history for all of them. Results presented here concern 247 cases and 254 controls.
Taking non- or light smokers as the reference category, we estimated odds ratios (OR) of 4.2 (95% CI: 2.6-6.7) and 5.2 (95% CI: 3.3-8.3) for the medium and heavy smokers respectively. On the other hand we estimated that the crude OR associating GSTM1 with lung cancer was 1.3 (95% CI: 0.9-1.8). Furthermore our data do not depart significantly from a multiplicative model of the combined effects of smoking and GSTM1 deficiency.
We conclude that smoking and the GSTM1 gene are each a risk factor for lung cancer, and that their combined effect does not differ significantly from that of a multiplicative model.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Confidence Intervals</subject><subject>Female</subject><subject>France - epidemiology</subject><subject>Genetic Predisposition to Disease - epidemiology</subject><subject>Glutathione Transferase - genetics</subject><subject>Glutathione Transferase - metabolism</subject><subject>Health Surveys</subject><subject>Humans</subject><subject>Incidence</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Pneumology</subject><subject>Polymorphism, Genetic</subject><subject>Reference Values</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Sampling Studies</subject><subject>Smoking - adverse effects</subject><subject>Smoking - epidemiology</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0300-5771</issn><issn>1464-3685</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EoqWwMaMIISbS-uxzbLOhii-piIHulus4KCVNwG6G_ntctRKIhene4dF7dw8h50DHQDWf1Es_YWosxorpAzIELDDnhRKHZEg5pbmQEgbkJMYlpYCI-pgMgAottVRDIh7f5i9wk8VV91G375lty6zpU3C2dT5kt5lNMfrcde06dE0W1325OSVHlW2iP9vPEZk_3M-nT_ns9fF5ejfLHQJb55UCbkEJVFQU6CW1bKE1OokWnUIJqnC2QCi5qrizUCkHpdMps4pZzkfkelf7Gbqv3se1WdXR-aaxre_6aArNBU-b_gVBIgrk28bLP-Cy60ObfjAMdLoHmErQzQ5yoYsx-Mp8hnplw8YANVvnJjk3TBlhkvOEX-w7-8XKl7_gneQEXO0BG51tqpDU1vGH00mFpPwbfpSF4w</recordid><startdate>19991001</startdate><enddate>19991001</enddate><creator>STÜCKER, I</creator><creator>DE WAZIERS, I</creator><creator>CENEE, S</creator><creator>BIGNON, J</creator><creator>DEPIERRE, A</creator><creator>MILLERON, B</creator><creator>BEAUNE, P</creator><creator>HEMON, D</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19991001</creationdate><title>GSTM1, smoking and lung cancer : a case-control study</title><author>STÜCKER, I ; DE WAZIERS, I ; CENEE, S ; BIGNON, J ; DEPIERRE, A ; MILLERON, B ; BEAUNE, P ; HEMON, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-f813a185480564e70a2b994c74a4c847186ca641d38f3ca1f8c1dc9f3c2f2a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Confidence Intervals</topic><topic>Female</topic><topic>France - epidemiology</topic><topic>Genetic Predisposition to Disease - epidemiology</topic><topic>Glutathione Transferase - genetics</topic><topic>Glutathione Transferase - metabolism</topic><topic>Health Surveys</topic><topic>Humans</topic><topic>Incidence</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Lung Neoplasms - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Pneumology</topic><topic>Polymorphism, Genetic</topic><topic>Reference Values</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Sampling Studies</topic><topic>Smoking - adverse effects</topic><topic>Smoking - epidemiology</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STÜCKER, I</creatorcontrib><creatorcontrib>DE WAZIERS, I</creatorcontrib><creatorcontrib>CENEE, S</creatorcontrib><creatorcontrib>BIGNON, J</creatorcontrib><creatorcontrib>DEPIERRE, A</creatorcontrib><creatorcontrib>MILLERON, B</creatorcontrib><creatorcontrib>BEAUNE, P</creatorcontrib><creatorcontrib>HEMON, D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>STÜCKER, I</au><au>DE WAZIERS, I</au><au>CENEE, S</au><au>BIGNON, J</au><au>DEPIERRE, A</au><au>MILLERON, B</au><au>BEAUNE, P</au><au>HEMON, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GSTM1, smoking and lung cancer : a case-control study</atitle><jtitle>International journal of epidemiology</jtitle><addtitle>Int J Epidemiol</addtitle><date>1999-10-01</date><risdate>1999</risdate><volume>28</volume><issue>5</issue><spage>829</spage><epage>835</epage><pages>829-835</pages><issn>0300-5771</issn><eissn>1464-3685</eissn><coden>IJEPBF</coden><abstract>We conducted a case-control study to examine the risk of lung cancer in relation to GSTM1 polymorphism and cigarette smoking (primarily of black tobacco) in a French population.
The 611 subjects were 301 incident lung cancer cases and 310 hospital controls. We were able to constitute a DNA bank for 547 subjects (89.5%) and gather detailed information on smoking history for all of them. Results presented here concern 247 cases and 254 controls.
Taking non- or light smokers as the reference category, we estimated odds ratios (OR) of 4.2 (95% CI: 2.6-6.7) and 5.2 (95% CI: 3.3-8.3) for the medium and heavy smokers respectively. On the other hand we estimated that the crude OR associating GSTM1 with lung cancer was 1.3 (95% CI: 0.9-1.8). Furthermore our data do not depart significantly from a multiplicative model of the combined effects of smoking and GSTM1 deficiency.
We conclude that smoking and the GSTM1 gene are each a risk factor for lung cancer, and that their combined effect does not differ significantly from that of a multiplicative model.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>10597978</pmid><doi>10.1093/ije/28.5.829</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Age Distribution Aged Analysis of Variance Biological and medical sciences Case-Control Studies Confidence Intervals Female France - epidemiology Genetic Predisposition to Disease - epidemiology Glutathione Transferase - genetics Glutathione Transferase - metabolism Health Surveys Humans Incidence Lung Neoplasms - epidemiology Lung Neoplasms - genetics Male Medical sciences Middle Aged Odds Ratio Pneumology Polymorphism, Genetic Reference Values Risk Assessment Risk Factors Sampling Studies Smoking - adverse effects Smoking - epidemiology Tumors of the respiratory system and mediastinum |
| title | GSTM1, smoking and lung cancer : a case-control study |
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