Acetylation: a novel method for modulation of the immune response following trauma/hemorrhage and inflammatory second hit in animals and humans

Background Hemorrhage induces an imbalance in histone acetyl transferase/histone deacetylase (HAT/HDAC) ratio. Correction of this imbalance with histone deacetylase inhibitors (HDACI) improves survival. We aimed to identify whether this was due to modulation of the post-shock immune response. Method...

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Veröffentlicht in:	Surgery 2008-08, Vol.144 (2), p.204-216
Hauptverfasser:	Sailhamer, Elizabeth A., MD, Li, Yongqing, MD, PhD, Smith, Eleanor J, Shuja, Fahad, MD, Shults, Christian, MD, Liu, Baoling, MD, Soupir, Chad, MD, deMoya, Marc, MD, Velmahos, George, MD, Alam, Hasan B., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Injuries - metabolism Acetylation Adult Animals Biological and medical sciences Cell Culture Techniques Female General aspects Hemorrhage - metabolism Hemorrhage - physiopathology Histone Acetyltransferases - metabolism Histone Deacetylase Inhibitors Histone Deacetylases - metabolism Humans Hydroxamic Acids - pharmacology Inflammation Interleukin-1beta - blood Interleukin-1beta - genetics Leukocytes - metabolism Lipopolysaccharides - pharmacology Male Medical sciences Rats Rats, Inbred WKY Shock, Hemorrhagic - complications Shock, Hemorrhagic - immunology Shock, Hemorrhagic - metabolism Shock, Hemorrhagic - therapy Spleen - metabolism Splenectomy Surgery Systemic Inflammatory Response Syndrome - etiology Systemic Inflammatory Response Syndrome - metabolism Transcriptional Activation Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - genetics
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