A Negative Regulatory Role for Ig-α during B Cell Development
The development of B cells requires the expression of an antigen receptor at distinct points during maturation. The Ig-α/β heterodimer signals for these receptors, and mice harboring a truncation of the Ig-α intracellular domain ( mb-1 Δc/Δc ) have severely reduced peripheral B cell numbers. Here we...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 1999-11, Vol.11 (5), p.527-536 |
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| creator | Torres, Raul M Hafen, Katrin |
| description | The development of B cells requires the expression of an antigen receptor at distinct points during maturation. The Ig-α/β heterodimer signals for these receptors, and mice harboring a truncation of the Ig-α intracellular domain (
mb-1
Δc/Δc
) have severely reduced peripheral B cell numbers. Here we report that immature
mb-1
Δc/Δc
B cells are activated despite lacking a critical Ig-α-positive signaling motif. As a consequence of abnormal activation, transitional immature IgM
highIgD
low B cells are largely absent in
mb-1
Δc/Δc
mutants, accounting for the paucity of mature B cells. Thus, Ig-α cytoplasmic tail truncation yields an antigen receptor complex on immature B cells that signals constitutively. These data illustrate a role for Ig-α in negatively regulating antigen receptor signaling during B cell development. |
| doi_str_mv | 10.1016/S1074-7613(00)80128-4 |
| format | Article |
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mb-1
Δc/Δc
) have severely reduced peripheral B cell numbers. Here we report that immature
mb-1
Δc/Δc
B cells are activated despite lacking a critical Ig-α-positive signaling motif. As a consequence of abnormal activation, transitional immature IgM
highIgD
low B cells are largely absent in
mb-1
Δc/Δc
mutants, accounting for the paucity of mature B cells. Thus, Ig-α cytoplasmic tail truncation yields an antigen receptor complex on immature B cells that signals constitutively. These data illustrate a role for Ig-α in negatively regulating antigen receptor signaling during B cell development.</description><identifier>ISSN: 1074-7613</identifier><identifier>EISSN: 1097-4180</identifier><identifier>DOI: 10.1016/S1074-7613(00)80128-4</identifier><identifier>PMID: 10591178</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>AB-cell receptor ; Animals ; Antigens, CD - biosynthesis ; Antigens, CD - chemistry ; Antigens, CD - genetics ; Antigens, CD - physiology ; B-Lymphocytes - cytology ; B7-2 Antigen ; CD79 Antigens ; Dimerization ; Immunoglobulin M - biosynthesis ; Immunophenotyping ; Liver - cytology ; Liver - embryology ; Lymphocyte Count ; Lymphoid Tissue - pathology ; Membrane Glycoproteins - biosynthesis ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Phosphorylation ; Protein Processing, Post-Translational ; Protein-Tyrosine Kinases - metabolism ; Receptors, Antigen, B-Cell - chemistry ; Receptors, Antigen, B-Cell - genetics ; Receptors, Antigen, B-Cell - physiology ; Sequence Deletion ; Signal Transduction ; Specific Pathogen-Free Organisms ; Terminator Regions, Genetic</subject><ispartof>Immunity (Cambridge, Mass.), 1999-11, Vol.11 (5), p.527-536</ispartof><rights>1999 Cell Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-1e354c7899c058de23dad91106c280d4d444d37b6667c5549bf16125837ccad93</citedby><cites>FETCH-LOGICAL-c439t-1e354c7899c058de23dad91106c280d4d444d37b6667c5549bf16125837ccad93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1074-7613(00)80128-4$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10591178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Torres, Raul M</creatorcontrib><creatorcontrib>Hafen, Katrin</creatorcontrib><title>A Negative Regulatory Role for Ig-α during B Cell Development</title><title>Immunity (Cambridge, Mass.)</title><addtitle>Immunity</addtitle><description>The development of B cells requires the expression of an antigen receptor at distinct points during maturation. The Ig-α/β heterodimer signals for these receptors, and mice harboring a truncation of the Ig-α intracellular domain (
mb-1
Δc/Δc
) have severely reduced peripheral B cell numbers. Here we report that immature
mb-1
Δc/Δc
B cells are activated despite lacking a critical Ig-α-positive signaling motif. As a consequence of abnormal activation, transitional immature IgM
highIgD
low B cells are largely absent in
mb-1
Δc/Δc
mutants, accounting for the paucity of mature B cells. Thus, Ig-α cytoplasmic tail truncation yields an antigen receptor complex on immature B cells that signals constitutively. These data illustrate a role for Ig-α in negatively regulating antigen receptor signaling during B cell development.</description><subject>AB-cell receptor</subject><subject>Animals</subject><subject>Antigens, CD - biosynthesis</subject><subject>Antigens, CD - chemistry</subject><subject>Antigens, CD - genetics</subject><subject>Antigens, CD - physiology</subject><subject>B-Lymphocytes - cytology</subject><subject>B7-2 Antigen</subject><subject>CD79 Antigens</subject><subject>Dimerization</subject><subject>Immunoglobulin M - biosynthesis</subject><subject>Immunophenotyping</subject><subject>Liver - cytology</subject><subject>Liver - embryology</subject><subject>Lymphocyte Count</subject><subject>Lymphoid Tissue - pathology</subject><subject>Membrane Glycoproteins - biosynthesis</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Transgenic</subject><subject>Phosphorylation</subject><subject>Protein Processing, Post-Translational</subject><subject>Protein-Tyrosine Kinases - metabolism</subject><subject>Receptors, Antigen, B-Cell - chemistry</subject><subject>Receptors, Antigen, B-Cell - genetics</subject><subject>Receptors, Antigen, B-Cell - physiology</subject><subject>Sequence Deletion</subject><subject>Signal Transduction</subject><subject>Specific Pathogen-Free Organisms</subject><subject>Terminator Regions, Genetic</subject><issn>1074-7613</issn><issn>1097-4180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0E4v0JIK8QLAIziV_ZgEp5ShVIBdZWak-roLQpdlKJz-JH-CZS2gU7VjOLc-eODmNHCOcIqC5eELRItMLsFODMAKYmERtsFyHXiUADm8t9jeywvRjfAVDIHLbZDoLMEbXZZZc9_kSToikXxIc0aauiqcMnH9YV8XEd-OMk-f7ivg3lbMKveZ-qit_Qgqp6PqVZc8C2xkUV6XA999nb3e1r_yEZPN8_9nuDxIksbxKkTAqnTZ47kMZTmvnCdx-AcqkBL7wQwmd6pJTSTkqRj8aoMJUm0851ZLbPTlZ356H-aCk2dlpG1z1TzKhuo1V5JlOj9b8gaiFQGdOBcgW6UMcYaGznoZwW4dMi2KVh-2vYLvVZAPtr2Ioud7wuaEdT8n9SK6UdcLUCqPOxKCnY6EqaOfJlINdYX5f_VPwA646ItQ</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>Torres, Raul M</creator><creator>Hafen, Katrin</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19991101</creationdate><title>A Negative Regulatory Role for Ig-α during B Cell Development</title><author>Torres, Raul M ; Hafen, Katrin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-1e354c7899c058de23dad91106c280d4d444d37b6667c5549bf16125837ccad93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>AB-cell receptor</topic><topic>Animals</topic><topic>Antigens, CD - biosynthesis</topic><topic>Antigens, CD - chemistry</topic><topic>Antigens, CD - genetics</topic><topic>Antigens, CD - physiology</topic><topic>B-Lymphocytes - cytology</topic><topic>B7-2 Antigen</topic><topic>CD79 Antigens</topic><topic>Dimerization</topic><topic>Immunoglobulin M - biosynthesis</topic><topic>Immunophenotyping</topic><topic>Liver - cytology</topic><topic>Liver - embryology</topic><topic>Lymphocyte Count</topic><topic>Lymphoid Tissue - pathology</topic><topic>Membrane Glycoproteins - biosynthesis</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Transgenic</topic><topic>Phosphorylation</topic><topic>Protein Processing, Post-Translational</topic><topic>Protein-Tyrosine Kinases - metabolism</topic><topic>Receptors, Antigen, B-Cell - chemistry</topic><topic>Receptors, Antigen, B-Cell - genetics</topic><topic>Receptors, Antigen, B-Cell - physiology</topic><topic>Sequence Deletion</topic><topic>Signal Transduction</topic><topic>Specific Pathogen-Free Organisms</topic><topic>Terminator Regions, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Torres, Raul M</creatorcontrib><creatorcontrib>Hafen, Katrin</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunity (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Torres, Raul M</au><au>Hafen, Katrin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Negative Regulatory Role for Ig-α during B Cell Development</atitle><jtitle>Immunity (Cambridge, Mass.)</jtitle><addtitle>Immunity</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>11</volume><issue>5</issue><spage>527</spage><epage>536</epage><pages>527-536</pages><issn>1074-7613</issn><eissn>1097-4180</eissn><abstract>The development of B cells requires the expression of an antigen receptor at distinct points during maturation. The Ig-α/β heterodimer signals for these receptors, and mice harboring a truncation of the Ig-α intracellular domain (
mb-1
Δc/Δc
) have severely reduced peripheral B cell numbers. Here we report that immature
mb-1
Δc/Δc
B cells are activated despite lacking a critical Ig-α-positive signaling motif. As a consequence of abnormal activation, transitional immature IgM
highIgD
low B cells are largely absent in
mb-1
Δc/Δc
mutants, accounting for the paucity of mature B cells. Thus, Ig-α cytoplasmic tail truncation yields an antigen receptor complex on immature B cells that signals constitutively. These data illustrate a role for Ig-α in negatively regulating antigen receptor signaling during B cell development.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>10591178</pmid><doi>10.1016/S1074-7613(00)80128-4</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Immunity (Cambridge, Mass.), 1999-11, Vol.11 (5), p.527-536 |
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| language | eng |
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| source | MEDLINE; Cell Press Free Archives; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals |
| subjects | AB-cell receptor Animals Antigens, CD - biosynthesis Antigens, CD - chemistry Antigens, CD - genetics Antigens, CD - physiology B-Lymphocytes - cytology B7-2 Antigen CD79 Antigens Dimerization Immunoglobulin M - biosynthesis Immunophenotyping Liver - cytology Liver - embryology Lymphocyte Count Lymphoid Tissue - pathology Membrane Glycoproteins - biosynthesis Mice Mice, Inbred C57BL Mice, Transgenic Phosphorylation Protein Processing, Post-Translational Protein-Tyrosine Kinases - metabolism Receptors, Antigen, B-Cell - chemistry Receptors, Antigen, B-Cell - genetics Receptors, Antigen, B-Cell - physiology Sequence Deletion Signal Transduction Specific Pathogen-Free Organisms Terminator Regions, Genetic |
| title | A Negative Regulatory Role for Ig-α during B Cell Development |
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