Regulation of glucose transport and glycogen synthesis in L6 muscle cells during oxidative stress. Evidence for cross-talk between the insulin and SAPK2/p38 mitogen-activated protein kinase signaling pathways

We have investigated the cellular mechanisms that participate in reducing insulin sensitivity in response to increased oxidant stress in skeletal muscle. Measurement of glucose transport and glycogen synthesis in L6 myotubes showed that insulin stimulated both processes, by 2- and 5-fold, respective...

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Veröffentlicht in:	The Journal of biological chemistry 1999-12, Vol.274 (51), p.36293-36299
Hauptverfasser:	Blair, A S, Hajduch, E, Litherland, G J, Hundal, H S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Cell Line Glucose - metabolism glucose transport glycogen Glycogen - biosynthesis Insulin - metabolism Mitogen-Activated Protein Kinases - metabolism Muscle, Skeletal - metabolism Oxidative Stress p38 Mitogen-Activated Protein Kinases Rats Receptor, Insulin - metabolism Signal Transduction
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