Embryonic development in the reduced folate carrier knockout mouse is modulated by maternal folate supplementation

BACKGROUND: The reduced folate carrier (RFC1) is a ubiquitously expressed integral membrane protein that mediates delivery of 5‐methyltetrahydrofolate into mammalian cells. In this study, embryonic/fetal development is characterized in an RFC1 knockout mouse model in which pregnant dams receive diff...

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Veröffentlicht in:	Birth defects research. A Clinical and molecular teratology 2008-07, Vol.82 (7), p.494-507
Hauptverfasser:	Gelineau-van Waes, Janee, Heller, Steven, Bauer, Linda K., Wilberding, Justin, Maddox, Joyce R., Aleman, Francisco, Rosenquist, Thomas H., Finnell, Richard H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Multiple - epidemiology Abnormalities, Multiple - etiology Animals chorioallantoic fusion Chorioallantoic Membrane - drug effects Chorioallantoic Membrane - physiology Dietary Supplements Embryo, Mammalian - drug effects Embryo, Mammalian - physiology Embryonic Development - drug effects Erythropoiesis - drug effects Erythropoiesis - physiology Female Fgfr2 Folic Acid - administration & dosage Folic Acid - pharmacology Folic Acid Deficiency heart defects maternal folate supplementation Membrane Transport Proteins - genetics Mice Mice, Knockout neural tube defect Pregnancy reduced folate carrier knockout Reduced Folate Carrier Protein Slc19a1
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