The Influence of Nanomolar Ouabain on Vascular Pressor Responses is Modulated by the Endothelium

Ouabain has been shown to be an endogenous hormone that is synthesized and released from the adrenal cortex and is present in nanomolar to subnanomolar concentrations in plasma. It has been proposed that endogenous ouabain can increase vascular resistance and induce hypertension. This substance inhi...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1999-12, Vol.34 (6), p.887-892
Hauptverfasser:	Rossoni, L V, Cunha, V, França, A, Vassallo, D V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Cardiology. Vascular system Cardiotonic Agents - pharmacology Clinical manifestations. Epidemiology. Investigative techniques. Etiology Endothelium, Vascular - drug effects Enzyme Inhibitors - pharmacology In Vitro Techniques Male Medical sciences Ouabain - pharmacology Phenylephrine - pharmacology Rats Rats, Wistar Regional Blood Flow - drug effects Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors Tail - blood supply Vasoconstrictor Agents - pharmacology
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