Role of mean platelet volume in triagging acute coronary syndromes
Background : Acute coronary syndromes, characterized by the rupture of unstable plaque and the subsequent thrombotic process involving platelets, have been increasing in relative frequency. The central role of platelet activation has long been noticed in this pathophysiology; hence, many therapies h...
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| Veröffentlicht in: | Journal of thrombosis and thrombolysis 2008-08, Vol.26 (1), p.49-54 |
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| creator | Yilmaz, Mehmet Birhan Cihan, Gokhan Guray, Yesim Guray, Umit Kisacik, Halil L. Sasmaz, Hatice Korkmaz, Sule |
| description | Background
: Acute coronary syndromes, characterized by the rupture of unstable plaque and the subsequent thrombotic process involving platelets, have been increasing in relative frequency. The central role of platelet activation has long been noticed in this pathophysiology; hence, many therapies have been directed against it. In this study, we have aimed to search prospectively the value of mean platelet volume (MPV), which is a simple and accurate measure of the functional status of platelets, in patients hospitalized with diagnosis of acute coronary syndromes (ACS).
Materials and methods
: A total of 216 consecutive patients (156 male, 60 female) hospitalized with the diagnosis of non-ST segment elevation (NSTE) ACS within the first 24 h of their chest pain were enrolled. One hundred and twenty patients, matched according to sex and age, with stable coronary heart disease (CHD) (85 male, 35 female) were enrolled as a control group. Patients were classified into two group: those with unstable angina (USAP, n = 105) and those with non-ST segment elevation myocardial infarction (NSTEMI, n = 111).
Results
: MPVs were 10.4 ± 0.6 fL, 10 ± 0.7 fL, 8.9 ± 0.7 fL consecutively for NSTEMI, USAP and stable CHD with significant differences. Patients with ischemic attacks in the first day of hospitalization accompanied by >0.05 mV ST segment shift had significantly higher MPV compared to those without such attacks (
P
= 0.001). Multivariable logistic regression analysis yielded that MPV (
P
= 0.016), platelet count (
P
0.05 mV ST segment depression at admission (
P
= 0.002) were independent predictors of development of NSTEMI in patients presenting with NSTE ACS.
Conclusion
: In patients presenting with NSTE ACS, higher MPV, though there are overlaps among subgroups, indicates not only more risk of having NSTEMI but also ischemic complications. |
| doi_str_mv | 10.1007/s11239-007-0078-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69350517</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69350517</sourcerecordid><originalsourceid>FETCH-LOGICAL-c369t-eaa1b831e7329e3761c72b267abd8b52fe74b233b177257b96dd723bf337f7603</originalsourceid><addsrcrecordid>eNp1kE1LAzEQhoMotlZ_gBcJHryt5qPZNEctfkFBEAVvIdmdLVt2k5rsCv33ZtlCQfAwzMA8887Mi9AlJbeUEHkXKWVcZakcYpGpIzSlQvJMztnXMZoSxVQmOBETdBbjhhCiFGGnaEKlJIIIPkUP774B7CvcgnF425gOGujwj2_6FnDtcBdqs17Xbo1N0XeACx-8M2GH486VwbcQz9FJZZoIF_s8Q59Pjx_Ll2z19vy6vF9lBc9Vl4Ex1C44BcmZAi5zWkhmWS6NLRdWsArk3DLObTqOCWlVXpaScVtxLiuZEz5DN6PuNvjvHmKn2zoW0DTGge-jzhVPP1GZwOs_4Mb3waXbNGOEM0ZzkSA6QkXwMQao9DbUbXpMU6IHd_Xorh7KwV2t0szVXri3LZSHib2dCWAjEFPLrSEcNv-v-guOFoO9</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>220322165</pqid></control><display><type>article</type><title>Role of mean platelet volume in triagging acute coronary syndromes</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Yilmaz, Mehmet Birhan ; Cihan, Gokhan ; Guray, Yesim ; Guray, Umit ; Kisacik, Halil L. ; Sasmaz, Hatice ; Korkmaz, Sule</creator><creatorcontrib>Yilmaz, Mehmet Birhan ; Cihan, Gokhan ; Guray, Yesim ; Guray, Umit ; Kisacik, Halil L. ; Sasmaz, Hatice ; Korkmaz, Sule</creatorcontrib><description>Background
: Acute coronary syndromes, characterized by the rupture of unstable plaque and the subsequent thrombotic process involving platelets, have been increasing in relative frequency. The central role of platelet activation has long been noticed in this pathophysiology; hence, many therapies have been directed against it. In this study, we have aimed to search prospectively the value of mean platelet volume (MPV), which is a simple and accurate measure of the functional status of platelets, in patients hospitalized with diagnosis of acute coronary syndromes (ACS).
Materials and methods
: A total of 216 consecutive patients (156 male, 60 female) hospitalized with the diagnosis of non-ST segment elevation (NSTE) ACS within the first 24 h of their chest pain were enrolled. One hundred and twenty patients, matched according to sex and age, with stable coronary heart disease (CHD) (85 male, 35 female) were enrolled as a control group. Patients were classified into two group: those with unstable angina (USAP, n = 105) and those with non-ST segment elevation myocardial infarction (NSTEMI, n = 111).
Results
: MPVs were 10.4 ± 0.6 fL, 10 ± 0.7 fL, 8.9 ± 0.7 fL consecutively for NSTEMI, USAP and stable CHD with significant differences. Patients with ischemic attacks in the first day of hospitalization accompanied by >0.05 mV ST segment shift had significantly higher MPV compared to those without such attacks (
P
= 0.001). Multivariable logistic regression analysis yielded that MPV (
P
= 0.016), platelet count (
P
< 0.001), and the presence of >0.05 mV ST segment depression at admission (
P
= 0.002) were independent predictors of development of NSTEMI in patients presenting with NSTE ACS.
Conclusion
: In patients presenting with NSTE ACS, higher MPV, though there are overlaps among subgroups, indicates not only more risk of having NSTEMI but also ischemic complications.</description><identifier>ISSN: 0929-5305</identifier><identifier>EISSN: 1573-742X</identifier><identifier>DOI: 10.1007/s11239-007-0078-9</identifier><identifier>PMID: 17705053</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Acute Coronary Syndrome - blood ; Acute Coronary Syndrome - complications ; Acute Coronary Syndrome - therapy ; Aged ; Angina, Unstable - blood ; Angina, Unstable - etiology ; Blood Platelets - pathology ; Cardiology ; Case-Control Studies ; Cell Size ; Female ; Hematology ; Humans ; Logistic Models ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Myocardial Infarction - blood ; Myocardial Infarction - etiology ; Platelet Count ; Platelet Function Tests ; Prospective Studies ; Risk Assessment ; Risk Factors ; Triage</subject><ispartof>Journal of thrombosis and thrombolysis, 2008-08, Vol.26 (1), p.49-54</ispartof><rights>Springer Science+Business Media, LLC 2007</rights><rights>Springer Science+Business Media, LLC 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-eaa1b831e7329e3761c72b267abd8b52fe74b233b177257b96dd723bf337f7603</citedby><cites>FETCH-LOGICAL-c369t-eaa1b831e7329e3761c72b267abd8b52fe74b233b177257b96dd723bf337f7603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11239-007-0078-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11239-007-0078-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17705053$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yilmaz, Mehmet Birhan</creatorcontrib><creatorcontrib>Cihan, Gokhan</creatorcontrib><creatorcontrib>Guray, Yesim</creatorcontrib><creatorcontrib>Guray, Umit</creatorcontrib><creatorcontrib>Kisacik, Halil L.</creatorcontrib><creatorcontrib>Sasmaz, Hatice</creatorcontrib><creatorcontrib>Korkmaz, Sule</creatorcontrib><title>Role of mean platelet volume in triagging acute coronary syndromes</title><title>Journal of thrombosis and thrombolysis</title><addtitle>J Thromb Thrombolysis</addtitle><addtitle>J Thromb Thrombolysis</addtitle><description>Background
: Acute coronary syndromes, characterized by the rupture of unstable plaque and the subsequent thrombotic process involving platelets, have been increasing in relative frequency. The central role of platelet activation has long been noticed in this pathophysiology; hence, many therapies have been directed against it. In this study, we have aimed to search prospectively the value of mean platelet volume (MPV), which is a simple and accurate measure of the functional status of platelets, in patients hospitalized with diagnosis of acute coronary syndromes (ACS).
Materials and methods
: A total of 216 consecutive patients (156 male, 60 female) hospitalized with the diagnosis of non-ST segment elevation (NSTE) ACS within the first 24 h of their chest pain were enrolled. One hundred and twenty patients, matched according to sex and age, with stable coronary heart disease (CHD) (85 male, 35 female) were enrolled as a control group. Patients were classified into two group: those with unstable angina (USAP, n = 105) and those with non-ST segment elevation myocardial infarction (NSTEMI, n = 111).
Results
: MPVs were 10.4 ± 0.6 fL, 10 ± 0.7 fL, 8.9 ± 0.7 fL consecutively for NSTEMI, USAP and stable CHD with significant differences. Patients with ischemic attacks in the first day of hospitalization accompanied by >0.05 mV ST segment shift had significantly higher MPV compared to those without such attacks (
P
= 0.001). Multivariable logistic regression analysis yielded that MPV (
P
= 0.016), platelet count (
P
< 0.001), and the presence of >0.05 mV ST segment depression at admission (
P
= 0.002) were independent predictors of development of NSTEMI in patients presenting with NSTE ACS.
Conclusion
: In patients presenting with NSTE ACS, higher MPV, though there are overlaps among subgroups, indicates not only more risk of having NSTEMI but also ischemic complications.</description><subject>Acute Coronary Syndrome - blood</subject><subject>Acute Coronary Syndrome - complications</subject><subject>Acute Coronary Syndrome - therapy</subject><subject>Aged</subject><subject>Angina, Unstable - blood</subject><subject>Angina, Unstable - etiology</subject><subject>Blood Platelets - pathology</subject><subject>Cardiology</subject><subject>Case-Control Studies</subject><subject>Cell Size</subject><subject>Female</subject><subject>Hematology</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - etiology</subject><subject>Platelet Count</subject><subject>Platelet Function Tests</subject><subject>Prospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Triage</subject><issn>0929-5305</issn><issn>1573-742X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1LAzEQhoMotlZ_gBcJHryt5qPZNEctfkFBEAVvIdmdLVt2k5rsCv33ZtlCQfAwzMA8887Mi9AlJbeUEHkXKWVcZakcYpGpIzSlQvJMztnXMZoSxVQmOBETdBbjhhCiFGGnaEKlJIIIPkUP774B7CvcgnF425gOGujwj2_6FnDtcBdqs17Xbo1N0XeACx-8M2GH486VwbcQz9FJZZoIF_s8Q59Pjx_Ll2z19vy6vF9lBc9Vl4Ex1C44BcmZAi5zWkhmWS6NLRdWsArk3DLObTqOCWlVXpaScVtxLiuZEz5DN6PuNvjvHmKn2zoW0DTGge-jzhVPP1GZwOs_4Mb3waXbNGOEM0ZzkSA6QkXwMQao9DbUbXpMU6IHd_Xorh7KwV2t0szVXri3LZSHib2dCWAjEFPLrSEcNv-v-guOFoO9</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Yilmaz, Mehmet Birhan</creator><creator>Cihan, Gokhan</creator><creator>Guray, Yesim</creator><creator>Guray, Umit</creator><creator>Kisacik, Halil L.</creator><creator>Sasmaz, Hatice</creator><creator>Korkmaz, Sule</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20080801</creationdate><title>Role of mean platelet volume in triagging acute coronary syndromes</title><author>Yilmaz, Mehmet Birhan ; Cihan, Gokhan ; Guray, Yesim ; Guray, Umit ; Kisacik, Halil L. ; Sasmaz, Hatice ; Korkmaz, Sule</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-eaa1b831e7329e3761c72b267abd8b52fe74b233b177257b96dd723bf337f7603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acute Coronary Syndrome - blood</topic><topic>Acute Coronary Syndrome - complications</topic><topic>Acute Coronary Syndrome - therapy</topic><topic>Aged</topic><topic>Angina, Unstable - blood</topic><topic>Angina, Unstable - etiology</topic><topic>Blood Platelets - pathology</topic><topic>Cardiology</topic><topic>Case-Control Studies</topic><topic>Cell Size</topic><topic>Female</topic><topic>Hematology</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - etiology</topic><topic>Platelet Count</topic><topic>Platelet Function Tests</topic><topic>Prospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Triage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yilmaz, Mehmet Birhan</creatorcontrib><creatorcontrib>Cihan, Gokhan</creatorcontrib><creatorcontrib>Guray, Yesim</creatorcontrib><creatorcontrib>Guray, Umit</creatorcontrib><creatorcontrib>Kisacik, Halil L.</creatorcontrib><creatorcontrib>Sasmaz, Hatice</creatorcontrib><creatorcontrib>Korkmaz, Sule</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of thrombosis and thrombolysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yilmaz, Mehmet Birhan</au><au>Cihan, Gokhan</au><au>Guray, Yesim</au><au>Guray, Umit</au><au>Kisacik, Halil L.</au><au>Sasmaz, Hatice</au><au>Korkmaz, Sule</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of mean platelet volume in triagging acute coronary syndromes</atitle><jtitle>Journal of thrombosis and thrombolysis</jtitle><stitle>J Thromb Thrombolysis</stitle><addtitle>J Thromb Thrombolysis</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>26</volume><issue>1</issue><spage>49</spage><epage>54</epage><pages>49-54</pages><issn>0929-5305</issn><eissn>1573-742X</eissn><abstract>Background
: Acute coronary syndromes, characterized by the rupture of unstable plaque and the subsequent thrombotic process involving platelets, have been increasing in relative frequency. The central role of platelet activation has long been noticed in this pathophysiology; hence, many therapies have been directed against it. In this study, we have aimed to search prospectively the value of mean platelet volume (MPV), which is a simple and accurate measure of the functional status of platelets, in patients hospitalized with diagnosis of acute coronary syndromes (ACS).
Materials and methods
: A total of 216 consecutive patients (156 male, 60 female) hospitalized with the diagnosis of non-ST segment elevation (NSTE) ACS within the first 24 h of their chest pain were enrolled. One hundred and twenty patients, matched according to sex and age, with stable coronary heart disease (CHD) (85 male, 35 female) were enrolled as a control group. Patients were classified into two group: those with unstable angina (USAP, n = 105) and those with non-ST segment elevation myocardial infarction (NSTEMI, n = 111).
Results
: MPVs were 10.4 ± 0.6 fL, 10 ± 0.7 fL, 8.9 ± 0.7 fL consecutively for NSTEMI, USAP and stable CHD with significant differences. Patients with ischemic attacks in the first day of hospitalization accompanied by >0.05 mV ST segment shift had significantly higher MPV compared to those without such attacks (
P
= 0.001). Multivariable logistic regression analysis yielded that MPV (
P
= 0.016), platelet count (
P
< 0.001), and the presence of >0.05 mV ST segment depression at admission (
P
= 0.002) were independent predictors of development of NSTEMI in patients presenting with NSTE ACS.
Conclusion
: In patients presenting with NSTE ACS, higher MPV, though there are overlaps among subgroups, indicates not only more risk of having NSTEMI but also ischemic complications.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>17705053</pmid><doi>10.1007/s11239-007-0078-9</doi><tpages>6</tpages></addata></record> |
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| subjects | Acute Coronary Syndrome - blood Acute Coronary Syndrome - complications Acute Coronary Syndrome - therapy Aged Angina, Unstable - blood Angina, Unstable - etiology Blood Platelets - pathology Cardiology Case-Control Studies Cell Size Female Hematology Humans Logistic Models Male Medicine Medicine & Public Health Middle Aged Myocardial Infarction - blood Myocardial Infarction - etiology Platelet Count Platelet Function Tests Prospective Studies Risk Assessment Risk Factors Triage |
| title | Role of mean platelet volume in triagging acute coronary syndromes |
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