Succinylcholine: Adverse effects and alternatives in emergency medicine
Succinylcholine has long been the favored neuromuscular blocking agent for emergent airway management because of its rapid onset, dependable effect, and short duration. However, it has a plethora of undesirable side effects, ranging from the inconsequential to the catastrophic. When patients requiri...
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| Veröffentlicht in: | The American journal of emergency medicine 1999-11, Vol.17 (7), p.715-721 |
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| container_title | The American journal of emergency medicine |
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| creator | Orebaugh, Steven L |
| description | Succinylcholine has long been the favored neuromuscular blocking agent for emergent airway management because of its rapid onset, dependable effect, and short duration. However, it has a plethora of undesirable side effects, ranging from the inconsequential to the catastrophic. When patients requiring tracheal intubation present with potential contraindications to succinylcholine use, the emergency physician will need to substitute a rapid-onset nondepolarizing neuromuscular blocking agent, such as rocuronium or mivacurium. An understanding of the pharmacology of these agents is essential. |
| doi_str_mv | 10.1016/S0735-6757(99)90168-7 |
| format | Article |
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Drug treatments ; rapid sequence intubation ; Rocuronium ; succinylcholine ; Succinylcholine - pharmacology ; Succinylcholine - therapeutic use ; Time Factors</subject><ispartof>The American journal of emergency medicine, 1999-11, Vol.17 (7), p.715-721</ispartof><rights>1999</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-5cc6067797cdf8e11999cb72e54eedf5ac427522784a9348c0413292ad9503bb3</citedby><cites>FETCH-LOGICAL-c442t-5cc6067797cdf8e11999cb72e54eedf5ac427522784a9348c0413292ad9503bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0735-6757(99)90168-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1207024$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10597098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Orebaugh, Steven L</creatorcontrib><title>Succinylcholine: Adverse effects and alternatives in emergency medicine</title><title>The American journal of emergency medicine</title><addtitle>Am J Emerg Med</addtitle><description>Succinylcholine has long been the favored neuromuscular blocking agent for emergent airway management because of its rapid onset, dependable effect, and short duration. However, it has a plethora of undesirable side effects, ranging from the inconsequential to the catastrophic. When patients requiring tracheal intubation present with potential contraindications to succinylcholine use, the emergency physician will need to substitute a rapid-onset nondepolarizing neuromuscular blocking agent, such as rocuronium or mivacurium. An understanding of the pharmacology of these agents is essential.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Airway management</subject><subject>Androstanols - pharmacology</subject><subject>Androstanols - therapeutic use</subject><subject>Anesthetics. Neuromuscular blocking agents</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Contraindications</subject><subject>Emergency Medicine</subject><subject>Emergency Treatment - methods</subject><subject>Humans</subject><subject>Infant</subject><subject>Intubation, Intratracheal - methods</subject><subject>Isoquinolines - pharmacology</subject><subject>Isoquinolines - therapeutic use</subject><subject>Medical sciences</subject><subject>Mivacurium</subject><subject>mivacurium nondepolarizing neuromuscular blockade</subject><subject>Neuromuscular Depolarizing Agents - pharmacology</subject><subject>Neuromuscular Depolarizing Agents - therapeutic use</subject><subject>Neuromuscular Nondepolarizing Agents - pharmacology</subject><subject>Neuromuscular Nondepolarizing Agents - therapeutic use</subject><subject>Neuropharmacology</subject><subject>Patient Selection</subject><subject>Pharmacology. Drug treatments</subject><subject>rapid sequence intubation</subject><subject>Rocuronium</subject><subject>succinylcholine</subject><subject>Succinylcholine - pharmacology</subject><subject>Succinylcholine - therapeutic use</subject><subject>Time Factors</subject><issn>0735-6757</issn><issn>1532-8171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotlZ_grIHET2sJtlks_EipWgVCh6q55DOzmpku6vJttB_b_qBevM0MDzvfDyEnDJ6zSjLb6ZUZTLNlVSXWl_p2CpStUf6TGY8LZhi-6T_g_TIUQgflDImpDgkPUalVlQXfTKeLgBcs6rhva1dg7fJsFyiD5hgVSF0IbFNmdi6Q9_Yzi0xJK5JcI7-DRtYJXMsXczjMTmobB3wZFcH5PXh_mX0mE6ex0-j4SQFIXiXSoCc5kppBWVVIGNaa5gpjlIglpW0ILiSnKtCWJ2JAqhgGdfcllrSbDbLBuRiO_fTt18LDJ2ZuwBY17bBdhFMHlM6L0QE5RYE34bgsTKf3s2tXxlGzdqg2Rg0az1Ga7MxaFTMne0WLGbxuT-prbIInO8AG8DWlbcNuPDLcaooX--_22IYbSwdehPARWXRl49eTdm6fy75BjdkjNQ</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>Orebaugh, Steven L</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991101</creationdate><title>Succinylcholine: Adverse effects and alternatives in emergency medicine</title><author>Orebaugh, Steven L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-5cc6067797cdf8e11999cb72e54eedf5ac427522784a9348c0413292ad9503bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Airway management</topic><topic>Androstanols - pharmacology</topic><topic>Androstanols - therapeutic use</topic><topic>Anesthetics. Neuromuscular blocking agents</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Contraindications</topic><topic>Emergency Medicine</topic><topic>Emergency Treatment - methods</topic><topic>Humans</topic><topic>Infant</topic><topic>Intubation, Intratracheal - methods</topic><topic>Isoquinolines - pharmacology</topic><topic>Isoquinolines - therapeutic use</topic><topic>Medical sciences</topic><topic>Mivacurium</topic><topic>mivacurium nondepolarizing neuromuscular blockade</topic><topic>Neuromuscular Depolarizing Agents - pharmacology</topic><topic>Neuromuscular Depolarizing Agents - therapeutic use</topic><topic>Neuromuscular Nondepolarizing Agents - pharmacology</topic><topic>Neuromuscular Nondepolarizing Agents - therapeutic use</topic><topic>Neuropharmacology</topic><topic>Patient Selection</topic><topic>Pharmacology. Drug treatments</topic><topic>rapid sequence intubation</topic><topic>Rocuronium</topic><topic>succinylcholine</topic><topic>Succinylcholine - pharmacology</topic><topic>Succinylcholine - therapeutic use</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Orebaugh, Steven L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Orebaugh, Steven L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Succinylcholine: Adverse effects and alternatives in emergency medicine</atitle><jtitle>The American journal of emergency medicine</jtitle><addtitle>Am J Emerg Med</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>17</volume><issue>7</issue><spage>715</spage><epage>721</epage><pages>715-721</pages><issn>0735-6757</issn><eissn>1532-8171</eissn><coden>AJEMEN</coden><abstract>Succinylcholine has long been the favored neuromuscular blocking agent for emergent airway management because of its rapid onset, dependable effect, and short duration. However, it has a plethora of undesirable side effects, ranging from the inconsequential to the catastrophic. When patients requiring tracheal intubation present with potential contraindications to succinylcholine use, the emergency physician will need to substitute a rapid-onset nondepolarizing neuromuscular blocking agent, such as rocuronium or mivacurium. An understanding of the pharmacology of these agents is essential.</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>10597098</pmid><doi>10.1016/S0735-6757(99)90168-7</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-6757 |
| ispartof | The American journal of emergency medicine, 1999-11, Vol.17 (7), p.715-721 |
| issn | 0735-6757 1532-8171 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Age Factors Airway management Androstanols - pharmacology Androstanols - therapeutic use Anesthetics. Neuromuscular blocking agents Biological and medical sciences Child Contraindications Emergency Medicine Emergency Treatment - methods Humans Infant Intubation, Intratracheal - methods Isoquinolines - pharmacology Isoquinolines - therapeutic use Medical sciences Mivacurium mivacurium nondepolarizing neuromuscular blockade Neuromuscular Depolarizing Agents - pharmacology Neuromuscular Depolarizing Agents - therapeutic use Neuromuscular Nondepolarizing Agents - pharmacology Neuromuscular Nondepolarizing Agents - therapeutic use Neuropharmacology Patient Selection Pharmacology. Drug treatments rapid sequence intubation Rocuronium succinylcholine Succinylcholine - pharmacology Succinylcholine - therapeutic use Time Factors |
| title | Succinylcholine: Adverse effects and alternatives in emergency medicine |
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