Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolation
Isolating rats immediately after conditioning impairs contextual but not auditory-cue fear conditioning. The reported experiments examine the involvement of brain interleukin-1β (IL-1β) in the impairment in contextual fear conditioning caused by social isolation. As measured by the conditioned freez...
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| Veröffentlicht in: | Behavioural brain research 1999-12, Vol.106 (1), p.109-118 |
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| creator | Pugh, C.Rachal Nguyen, Kien T Gonyea, Jennifer L Fleshner, Monika Watkins, Linda R Maier, Steven F Rudy, Jerry W |
| description | Isolating rats immediately after conditioning impairs contextual but not auditory-cue fear conditioning. The reported experiments examine the involvement of brain interleukin-1β (IL-1β) in the impairment in contextual fear conditioning caused by social isolation. As measured by the conditioned freezing response, 5 h of social isolation after conditioning, impaired contextual but not auditory-cue fear conditioning in adult male Sprague–Dawley rats. Social isolation for 1 or 3 h after conditioning also increased IL-1β protein in the hippocampus and cerebral cortex. No differences in IL-1β protein levels were found in the pituitary or the hypothalamus. Intracerebroventricular (ICV) IL-1 receptor antagonist (IL-1ra) given after conditioning prevented the impairment in contextual fear conditioning caused by isolation. ICV IL-1ra had no effect on auditory-cue fear conditioning in these same animals, nor did it affect the level of contextual fear conditioning displayed by home cage controls. Like isolation, ICV IL-1β (10 or 20 ng) after conditioning also impaired contextual but not auditory-cue fear conditioning. These results suggest that increased levels of brain IL-1β play a role in producing the impairment in contextual fear conditioning produced by social isolation. These findings also add to the generality of the idea that stressors induce IL-1β activity in the brain and that IL-1β may play physiological roles in the uninjured brain. |
| doi_str_mv | 10.1016/S0166-4328(99)00098-4 |
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The reported experiments examine the involvement of brain interleukin-1β (IL-1β) in the impairment in contextual fear conditioning caused by social isolation. As measured by the conditioned freezing response, 5 h of social isolation after conditioning, impaired contextual but not auditory-cue fear conditioning in adult male Sprague–Dawley rats. Social isolation for 1 or 3 h after conditioning also increased IL-1β protein in the hippocampus and cerebral cortex. No differences in IL-1β protein levels were found in the pituitary or the hypothalamus. Intracerebroventricular (ICV) IL-1 receptor antagonist (IL-1ra) given after conditioning prevented the impairment in contextual fear conditioning caused by isolation. ICV IL-1ra had no effect on auditory-cue fear conditioning in these same animals, nor did it affect the level of contextual fear conditioning displayed by home cage controls. Like isolation, ICV IL-1β (10 or 20 ng) after conditioning also impaired contextual but not auditory-cue fear conditioning. These results suggest that increased levels of brain IL-1β play a role in producing the impairment in contextual fear conditioning produced by social isolation. These findings also add to the generality of the idea that stressors induce IL-1β activity in the brain and that IL-1β may play physiological roles in the uninjured brain.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/S0166-4328(99)00098-4</identifier><identifier>PMID: 10595426</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Acoustic Stimulation ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Brain ; Brain Chemistry - physiology ; Conditioning (Psychology) - physiology ; Cues ; Dose-Response Relationship, Drug ; Fear - physiology ; Fear - psychology ; Fundamental and applied biological sciences. Psychology ; Hippocampus ; Humans ; Immunology and behavior ; interleukin 1^b ; interleukin 1b ; Interleukin-1 - administration & dosage ; Interleukin-1 - metabolism ; Interleukin-1 - pharmacology ; Intracerebroventricular ; Learning ; Long-Term Potentiation - physiology ; Male ; Microinjections ; Proinflammatory cytokines ; Psychology. Psychoanalysis. Psychiatry ; Psychology. 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The reported experiments examine the involvement of brain interleukin-1β (IL-1β) in the impairment in contextual fear conditioning caused by social isolation. As measured by the conditioned freezing response, 5 h of social isolation after conditioning, impaired contextual but not auditory-cue fear conditioning in adult male Sprague–Dawley rats. Social isolation for 1 or 3 h after conditioning also increased IL-1β protein in the hippocampus and cerebral cortex. No differences in IL-1β protein levels were found in the pituitary or the hypothalamus. Intracerebroventricular (ICV) IL-1 receptor antagonist (IL-1ra) given after conditioning prevented the impairment in contextual fear conditioning caused by isolation. ICV IL-1ra had no effect on auditory-cue fear conditioning in these same animals, nor did it affect the level of contextual fear conditioning displayed by home cage controls. Like isolation, ICV IL-1β (10 or 20 ng) after conditioning also impaired contextual but not auditory-cue fear conditioning. These results suggest that increased levels of brain IL-1β play a role in producing the impairment in contextual fear conditioning produced by social isolation. These findings also add to the generality of the idea that stressors induce IL-1β activity in the brain and that IL-1β may play physiological roles in the uninjured brain.</description><subject>Acoustic Stimulation</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain Chemistry - physiology</subject><subject>Conditioning (Psychology) - physiology</subject><subject>Cues</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fear - physiology</subject><subject>Fear - psychology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Humans</subject><subject>Immunology and behavior</subject><subject>interleukin 1^b</subject><subject>interleukin 1b</subject><subject>Interleukin-1 - administration & dosage</subject><subject>Interleukin-1 - metabolism</subject><subject>Interleukin-1 - pharmacology</subject><subject>Intracerebroventricular</subject><subject>Learning</subject><subject>Long-Term Potentiation - physiology</subject><subject>Male</subject><subject>Microinjections</subject><subject>Proinflammatory cytokines</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Recombinant Proteins - administration & dosage</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Social Isolation - psychology</subject><subject>Space life sciences</subject><subject>Stress</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0Utv1DAQAGALUdGl8BNAOSAEh4DHj8Q-VajiUakSEo-z5UwmyJDEi51U9N_jdFfQWy-2bH8ztmcYewb8DXBo3n4tQ1MrKcwra19zzq2p1QO2A9OKutXKPmS7f-SUPc75Z0GKa3jEToFrq5Vodgy_xJGqOFRhXiiNtP4Kcw1VR4svW1WY9j6kieZlMxgL-rOsfqwG8mlb92EJcQ7zjwr9mqmvupsqRwyFhBxHv50-YSeDHzM9Pc5n7PuH998uPtVXnz9eXry7qlEJWGotRDeAJrTQEam2HbQ2QsvyAZRKG0RlrQLbaSugl74HidKajhtORjUgz9jLQ959ir9XyoubQkYaRz9TXLNrrFRWyfZeCK3iQmlVoD5ATDHnRIPbpzD5dOOAu60N7rYNbquxs9bdtsFtcc-PF6zdRP2dqEPdC3hxBD6jH4fkZwz5vwMDjRWFnR8YlbJdB0ouY6AZqQ-JcHF9DPe85C-KyKNn</recordid><startdate>19991201</startdate><enddate>19991201</enddate><creator>Pugh, C.Rachal</creator><creator>Nguyen, Kien T</creator><creator>Gonyea, Jennifer L</creator><creator>Fleshner, Monika</creator><creator>Watkins, Linda R</creator><creator>Maier, Steven F</creator><creator>Rudy, Jerry W</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19991201</creationdate><title>Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolation</title><author>Pugh, C.Rachal ; Nguyen, Kien T ; Gonyea, Jennifer L ; Fleshner, Monika ; Watkins, Linda R ; Maier, Steven F ; Rudy, Jerry W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-522bf15ec91bee477f558253432c3458cc499419b5921d3ad13c398b080e84613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Acoustic Stimulation</topic><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain Chemistry - physiology</topic><topic>Conditioning (Psychology) - physiology</topic><topic>Cues</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fear - physiology</topic><topic>Fear - psychology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus</topic><topic>Humans</topic><topic>Immunology and behavior</topic><topic>interleukin 1^b</topic><topic>interleukin 1b</topic><topic>Interleukin-1 - administration & dosage</topic><topic>Interleukin-1 - metabolism</topic><topic>Interleukin-1 - pharmacology</topic><topic>Intracerebroventricular</topic><topic>Learning</topic><topic>Long-Term Potentiation - physiology</topic><topic>Male</topic><topic>Microinjections</topic><topic>Proinflammatory cytokines</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Recombinant Proteins - administration & dosage</topic><topic>Recombinant Proteins - pharmacology</topic><topic>Social Isolation - psychology</topic><topic>Space life sciences</topic><topic>Stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pugh, C.Rachal</creatorcontrib><creatorcontrib>Nguyen, Kien T</creatorcontrib><creatorcontrib>Gonyea, Jennifer L</creatorcontrib><creatorcontrib>Fleshner, Monika</creatorcontrib><creatorcontrib>Watkins, Linda R</creatorcontrib><creatorcontrib>Maier, Steven F</creatorcontrib><creatorcontrib>Rudy, Jerry W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pugh, C.Rachal</au><au>Nguyen, Kien T</au><au>Gonyea, Jennifer L</au><au>Fleshner, Monika</au><au>Watkins, Linda R</au><au>Maier, Steven F</au><au>Rudy, Jerry W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolation</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>1999-12-01</date><risdate>1999</risdate><volume>106</volume><issue>1</issue><spage>109</spage><epage>118</epage><pages>109-118</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>Isolating rats immediately after conditioning impairs contextual but not auditory-cue fear conditioning. The reported experiments examine the involvement of brain interleukin-1β (IL-1β) in the impairment in contextual fear conditioning caused by social isolation. As measured by the conditioned freezing response, 5 h of social isolation after conditioning, impaired contextual but not auditory-cue fear conditioning in adult male Sprague–Dawley rats. Social isolation for 1 or 3 h after conditioning also increased IL-1β protein in the hippocampus and cerebral cortex. No differences in IL-1β protein levels were found in the pituitary or the hypothalamus. Intracerebroventricular (ICV) IL-1 receptor antagonist (IL-1ra) given after conditioning prevented the impairment in contextual fear conditioning caused by isolation. ICV IL-1ra had no effect on auditory-cue fear conditioning in these same animals, nor did it affect the level of contextual fear conditioning displayed by home cage controls. Like isolation, ICV IL-1β (10 or 20 ng) after conditioning also impaired contextual but not auditory-cue fear conditioning. These results suggest that increased levels of brain IL-1β play a role in producing the impairment in contextual fear conditioning produced by social isolation. These findings also add to the generality of the idea that stressors induce IL-1β activity in the brain and that IL-1β may play physiological roles in the uninjured brain.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>10595426</pmid><doi>10.1016/S0166-4328(99)00098-4</doi><tpages>10</tpages></addata></record> |
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| subjects | Acoustic Stimulation Animals Behavioral psychophysiology Biological and medical sciences Brain Brain Chemistry - physiology Conditioning (Psychology) - physiology Cues Dose-Response Relationship, Drug Fear - physiology Fear - psychology Fundamental and applied biological sciences. Psychology Hippocampus Humans Immunology and behavior interleukin 1^b interleukin 1b Interleukin-1 - administration & dosage Interleukin-1 - metabolism Interleukin-1 - pharmacology Intracerebroventricular Learning Long-Term Potentiation - physiology Male Microinjections Proinflammatory cytokines Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rat Rats Rats, Sprague-Dawley Recombinant Proteins - administration & dosage Recombinant Proteins - pharmacology Social Isolation - psychology Space life sciences Stress |
| title | Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolation |
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