How easily do topical antibiotics pass through tympanostomy tubes?—an in vitro study

Background: Despite potential ototoxicity, eardrops containing aminoglycosides remain in widespread use in the presence of indwelling tympanostomy tubes (grommets). It is unclear how readily they pass into the middle ear during administration, nor whether this is affected by middle ear secretions. M...

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Veröffentlicht in:	International journal of pediatric otorhinolaryngology 1999-10, Vol.50 (1), p.45-50
Hauptverfasser:	Saunders, M.W, Robinson, P.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Aminoglycosides Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Biological and medical sciences Drug toxicity and drugs side effects treatment Ear drops Ear, Middle - metabolism Grommets Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics Humans Kinetics Medical sciences Middle Ear Ventilation Models, Anatomic Models, Biological Ototoxicity Pharmacology. Drug treatments Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the ear, the auditive nerve and the facial nerve Toxicity: respiratory system, ent, stomatology Tympanostomy tubes
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