Role of prostaglandins generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia–reperfusion-induced gastric lesions

In this study, ischemia–reperfusion produced in rats by clamping the celiac artery for 0.5 h followed by 1 h of reperfusion was used to develop a new model of superficial gastric erosions progressing to deeper ulcers. Ischemia alone resulted in an immediate fall in gastric blood flow but no gross mu...

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Veröffentlicht in:	European journal of pharmacology 1999-11, Vol.385 (1), p.47-61
Hauptverfasser:	Brzozowski, Tomasz, Konturek, Peter Ch, Konturek, Stanislaw J, Sliwowski, Zbigniew, Drozdowicz, Danuta, Stachura, Jerzy, Pajdo, Robert, Hahn, Eckhart G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase inhibitor Cyclooxygenase Inhibitors - pharmacology Digestive system Dinoprostone - metabolism Dinoprostone - pharmacology Disease Models, Animal Gastric blood flow Gastric Mucosa - blood supply Gastric Mucosa - drug effects Gastric Mucosa - pathology Gastrin Gastrins - blood Gene Expression Regulation, Enzymologic Indomethacin - pharmacology Interleukin-1 - blood Interleukin-1β Ischemia–reperfusion Isoenzymes - genetics Isoenzymes - metabolism Isoenzymes - pharmacology Lactones - pharmacology Medical sciences Meloxicam Membrane Proteins Nitrobenzenes - pharmacology Pharmacology. Drug treatments Prostaglandin-Endoperoxide Synthases - genetics Prostaglandin-Endoperoxide Synthases - metabolism Prostaglandin-Endoperoxide Synthases - pharmacology Prostaglandins - metabolism Prostaglandins - pharmacology Prostaglandins - physiology Rats Regional Blood Flow - drug effects Reperfusion Injury - complications Reperfusion Injury - physiopathology Resveratrol Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Stilbenes - pharmacology Stomach Ulcer - drug therapy Stomach Ulcer - enzymology Stomach Ulcer - etiology Sulfonamides - pharmacology Sulfones Thiazines - pharmacology Thiazoles - pharmacology Time Factors Ulcer healing
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