Neurotrophin Binding to the p75 Receptor Modulates Rho Activity and Axonal Outgrowth
While the neurotrophin receptor p75 NTR is expressed by many developing neurons, its function in cells escaping elimination by programmed cell death remains unclear. The lack of intrinsic enzymatic activity of p75 NTR prompted a search for protein interactors expressed in the developing retina, whic...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 1999-11, Vol.24 (3), p.585-593 |
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| creator | Yamashita, Toshihide Tucker, Kerry Lee Barde, Yves-Alain |
| description | While the neurotrophin receptor p75
NTR is expressed by many developing neurons, its function in cells escaping elimination by programmed cell death remains unclear. The lack of intrinsic enzymatic activity of p75
NTR prompted a search for protein interactors expressed in the developing retina, which resulted in the identification of the GTPase RhoA. In transfected cells, p75
NTR activated RhoA, and neurotrophin binding abolished RhoA activation. In cultured neurons, inactivation of Rho proteins mimicked the effect of neurotrophins by increasing the rate of neurite elongation. In vivo, axonal outgrowth was retarded in mice carrying a mutation in the
p75
NTR
gene. These results indicate that p75
NTR modulates in a ligand-dependent fashion the activity of intracellular proteins known to regulate actin assembly. |
| doi_str_mv | 10.1016/S0896-6273(00)81114-9 |
| format | Article |
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NTR prompted a search for protein interactors expressed in the developing retina, which resulted in the identification of the GTPase RhoA. In transfected cells, p75
NTR activated RhoA, and neurotrophin binding abolished RhoA activation. In cultured neurons, inactivation of Rho proteins mimicked the effect of neurotrophins by increasing the rate of neurite elongation. In vivo, axonal outgrowth was retarded in mice carrying a mutation in the
p75
NTR
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NTR is expressed by many developing neurons, its function in cells escaping elimination by programmed cell death remains unclear. The lack of intrinsic enzymatic activity of p75
NTR prompted a search for protein interactors expressed in the developing retina, which resulted in the identification of the GTPase RhoA. In transfected cells, p75
NTR activated RhoA, and neurotrophin binding abolished RhoA activation. In cultured neurons, inactivation of Rho proteins mimicked the effect of neurotrophins by increasing the rate of neurite elongation. In vivo, axonal outgrowth was retarded in mice carrying a mutation in the
p75
NTR
gene. These results indicate that p75
NTR modulates in a ligand-dependent fashion the activity of intracellular proteins known to regulate actin assembly.</description><subject>Animals</subject><subject>Axons - physiology</subject><subject>Chick Embryo - cytology</subject><subject>Chick Embryo - physiology</subject><subject>Guanosine Diphosphate - metabolism</subject><subject>Ligands</subject><subject>Mice - embryology</subject><subject>Nerve Growth Factor - pharmacology</subject><subject>Nerve Growth Factors - metabolism</subject><subject>Neurites - physiology</subject><subject>Neurons - physiology</subject><subject>Neurons, Afferent - physiology</subject><subject>Receptor, Nerve Growth Factor - metabolism</subject><subject>Receptor, Nerve Growth Factor - physiology</subject><subject>rhoA GTP-Binding Protein - metabolism</subject><subject>rhoA GTP-Binding Protein - physiology</subject><subject>Spinal Cord - embryology</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFO3DAURa2Kqgy0nwDyCsEi4DeO43hVDQgoEmUkSteWY78wrjJxsB1a_r5hBlXd8TZvc-690iHkANgpMKjOfrBaVUU1l_yYsZMaAMpCfSAzYEoWJSi1Q2b_kF2yl9IvxqAUCj6RXWBCCQEwIw93OMaQYxhWvqfnvne-f6Q50LxCOkhB79HikEOk34MbO5Mx0ftVoAub_bPPL9T0ji7-hN50dDnmxxh-59Vn8rE1XcIvb3-f_Ly6fLj4Vtwur28uFreFFULmgjeCS2haaNG4igFvGi5Va0VV1m0JpmYo5w4NcCZrM52qpTIMpBENd6bm--Ro2zvE8DRiynrtk8WuMz2GMelK8VIqXr0LgqwE53OYQLEFbQwpRWz1EP3axBcNTL961xvv-lWqZkxvvGs15Q7fBsZmje6_1Fb0BHzdAjj5ePYYdbIee4vOR7RZu-DfmfgL4D6SKg</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>Yamashita, Toshihide</creator><creator>Tucker, Kerry Lee</creator><creator>Barde, Yves-Alain</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19991101</creationdate><title>Neurotrophin Binding to the p75 Receptor Modulates Rho Activity and Axonal Outgrowth</title><author>Yamashita, Toshihide ; Tucker, Kerry Lee ; Barde, Yves-Alain</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-3b5371bf1fead6013bb379fc5648f41a80e72dea13078aaaa9879a017a5b3da83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Axons - physiology</topic><topic>Chick Embryo - cytology</topic><topic>Chick Embryo - physiology</topic><topic>Guanosine Diphosphate - metabolism</topic><topic>Ligands</topic><topic>Mice - embryology</topic><topic>Nerve Growth Factor - pharmacology</topic><topic>Nerve Growth Factors - metabolism</topic><topic>Neurites - physiology</topic><topic>Neurons - physiology</topic><topic>Neurons, Afferent - physiology</topic><topic>Receptor, Nerve Growth Factor - metabolism</topic><topic>Receptor, Nerve Growth Factor - physiology</topic><topic>rhoA GTP-Binding Protein - metabolism</topic><topic>rhoA GTP-Binding Protein - physiology</topic><topic>Spinal Cord - embryology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamashita, Toshihide</creatorcontrib><creatorcontrib>Tucker, Kerry Lee</creatorcontrib><creatorcontrib>Barde, Yves-Alain</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamashita, Toshihide</au><au>Tucker, Kerry Lee</au><au>Barde, Yves-Alain</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurotrophin Binding to the p75 Receptor Modulates Rho Activity and Axonal Outgrowth</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><addtitle>Neuron</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>24</volume><issue>3</issue><spage>585</spage><epage>593</epage><pages>585-593</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><abstract>While the neurotrophin receptor p75
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NTR prompted a search for protein interactors expressed in the developing retina, which resulted in the identification of the GTPase RhoA. In transfected cells, p75
NTR activated RhoA, and neurotrophin binding abolished RhoA activation. In cultured neurons, inactivation of Rho proteins mimicked the effect of neurotrophins by increasing the rate of neurite elongation. In vivo, axonal outgrowth was retarded in mice carrying a mutation in the
p75
NTR
gene. These results indicate that p75
NTR modulates in a ligand-dependent fashion the activity of intracellular proteins known to regulate actin assembly.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>10595511</pmid><doi>10.1016/S0896-6273(00)81114-9</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Axons - physiology Chick Embryo - cytology Chick Embryo - physiology Guanosine Diphosphate - metabolism Ligands Mice - embryology Nerve Growth Factor - pharmacology Nerve Growth Factors - metabolism Neurites - physiology Neurons - physiology Neurons, Afferent - physiology Receptor, Nerve Growth Factor - metabolism Receptor, Nerve Growth Factor - physiology rhoA GTP-Binding Protein - metabolism rhoA GTP-Binding Protein - physiology Spinal Cord - embryology |
| title | Neurotrophin Binding to the p75 Receptor Modulates Rho Activity and Axonal Outgrowth |
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