Detailed immunophenotypic characterization of different major and minor subsets of peripheral blood cells in patients with paroxysmal nocturnal hemoglobinuria

BACKGROUND: Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by a deficient expression of glycosylphosphatidylinositol‐anchored proteins (GPI‐APs), due to somatic mutations of the phosphatidylinositolglycan complementation Class A (PIG‐A) gene. STUDY DESIGN AND METHODS: In this study, the...

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2008-07, Vol.48 (7), p.1403-1414
Hauptverfasser:	Hernández-Campo, Pilar M., Almeida, Julia, Acevedo, María J., Sánchez, María L., Alberca, Ignacio, Vidriales, Belén, Martínez, Elvira, Romero, Juan R., Orfao, Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-ribosyl Cyclase - blood Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antigens, CD - blood Biological and medical sciences Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Bone marrow, stem cells transplantation. Graft versus host reaction CD24 Antigen - blood CD55 Antigens - blood CD59 Antigens - blood Female GPI-Linked Proteins Hemoglobinuria, Paroxysmal - blood Hemoglobinuria, Paroxysmal - genetics Hemoglobinuria, Paroxysmal - immunology Humans Immunophenotyping - methods Lipopolysaccharide Receptors - blood Male Medical sciences Membrane Cofactor Protein - blood Membrane Proteins - blood Membrane Proteins - genetics Middle Aged Monocytes - cytology Monocytes - immunology Monocytes - metabolism Mutation Neutrophils - cytology Neutrophils - immunology Neutrophils - metabolism Receptors, IgG - blood Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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