Negative Inotropic Effect of Rapamycin on Isolated Human Cardiomyocytes

Rapamycin is an increasingly important immunosuppressive drug and reduces restenosis after coronary stenting, but its effects on cardiac contractility are largely unknown. We investigated the acute inotropic effects of rapamycin on isolated human cardiomyocytes. Cardiomyocytes were enzymatically iso...

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Veröffentlicht in:	Journal of international medical research 2008-07, Vol.36 (4), p.810-814
Hauptverfasser:	Möllmann, H, Nef, HM, Kahlert, P, Kostin, S, Möllmann, S, Weber, M, Troidl, C, Hamm, CW, Holubarsch, CJF, Elsässer, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium - metabolism Cell Shape Cells, Cultured Dose-Response Relationship, Drug Humans Immunosuppressive Agents - pharmacology Myocardial Contraction - drug effects Myocardial Contraction - physiology Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Sirolimus - pharmacology
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