Ataxia and Abnormal Cerebellar Microorganization in Mice with Ablated Contactin Gene Expression

Axon guidance and target recognition depend on neuronal cell surface receptors that recognize and elicit selective growth cone responses to guidance cues in the environment. Contactin, a cell adhesion/recognition molecule of the immunoglobulin gene superfamily, regulates axon growth and fasciculatio...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 1999-11, Vol.24 (3), p.739-750
Hauptverfasser:	Berglund, Erik O, Murai, Keith K, Fredette, Barbara, Sekerková, Gabriela, Marturano, Beatrice, Weber, Lynne, Mugnaini, Enrico, Ranscht, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn - metabolism Ataxia - complications Ataxia - genetics Ataxia - mortality Ataxia - pathology Cell Adhesion Molecules, Neuronal - genetics Cell Adhesion Molecules, Neuronal - metabolism Cerebellar Cortex - metabolism Cerebellum - pathology contactin Contactins Dendrites - pathology Dendrites - ultrastructure Golgi Apparatus - ultrastructure Mice Mice, Knockout - genetics Nerve Fibers - pathology Phenotype Purkinje Cells - ultrastructure
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