Unusual Spread of a Penicillin-Susceptible Methicillin-Resistant Staphylococcus aureus Clone in a Geographic Area of Low Incidence
We describe the unusual spread of a penicillin-susceptible methicillin-resistant Staphylococcus aureus (MRSA) clone in hospitals in western Switzerland, where the incidence of MRSA is usually low. During a 2-year period, this clone had been responsible for several outbreaks and had been isolated fro...
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| Veröffentlicht in: | Clinical infectious diseases 1999-12, Vol.29 (6), p.1512-1518 |
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| container_title | Clinical infectious diseases |
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| creator | Blanc, D. S. Petignat, C. Moreillon, P. Entenza, J. M. Eisenring, M.-C. Kleiber, H. Wenger, A. Troillet, N. Blanc, C.-H. Francioli, P. |
| description | We describe the unusual spread of a penicillin-susceptible methicillin-resistant Staphylococcus aureus (MRSA) clone in hospitals in western Switzerland, where the incidence of MRSA is usually low. During a 2-year period, this clone had been responsible for several outbreaks and had been isolated from >156 persons in 21 institutions. Molecular typing by pulsed-field gel electrophoresis (PFGE) demonstrated that all of these isolates belonged to the same clone. In 1 of the outbreaks, involving 30 cases, the clone was responsible for at least 17 secondary cases. In contrast, during the period of the latter outbreak, 9 other patients harboring different MRSA strains, as assessed by PFGE, were hospitalized in the same wards, but no secondary cases occurred. These observations suggest that this clone, compared with other MRSA strains, had some intrinsic factor(s) that contributed to its ability to disseminate and could thus be considered epidemic. |
| doi_str_mv | 10.1086/313522 |
| format | Article |
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S. ; Petignat, C. ; Moreillon, P. ; Entenza, J. M. ; Eisenring, M.-C. ; Kleiber, H. ; Wenger, A. ; Troillet, N. ; Blanc, C.-H. ; Francioli, P.</creator><creatorcontrib>Blanc, D. S. ; Petignat, C. ; Moreillon, P. ; Entenza, J. M. ; Eisenring, M.-C. ; Kleiber, H. ; Wenger, A. ; Troillet, N. ; Blanc, C.-H. ; Francioli, P.</creatorcontrib><description>We describe the unusual spread of a penicillin-susceptible methicillin-resistant Staphylococcus aureus (MRSA) clone in hospitals in western Switzerland, where the incidence of MRSA is usually low. During a 2-year period, this clone had been responsible for several outbreaks and had been isolated from >156 persons in 21 institutions. Molecular typing by pulsed-field gel electrophoresis (PFGE) demonstrated that all of these isolates belonged to the same clone. In 1 of the outbreaks, involving 30 cases, the clone was responsible for at least 17 secondary cases. In contrast, during the period of the latter outbreak, 9 other patients harboring different MRSA strains, as assessed by PFGE, were hospitalized in the same wards, but no secondary cases occurred. These observations suggest that this clone, compared with other MRSA strains, had some intrinsic factor(s) that contributed to its ability to disseminate and could thus be considered epidemic.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/313522</identifier><identifier>PMID: 10585805</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Anti-Bacterial Agents - pharmacology ; Antibiotics ; Bacterial diseases ; Biological and medical sciences ; Clinical Articles ; Cross Infection - microbiology ; Disease Outbreaks ; DNA, Bacterial - analysis ; Electrophoresis, Gel, Pulsed-Field ; Epidemics ; Gels ; Geography ; Hospital admissions ; Hospitalization ; Hospitals, University ; Human bacterial diseases ; Humans ; Incidence ; Infections ; Infectious diseases ; Medical sciences ; Methicillin Resistance ; Methicillin resistant staphylococcus aureus ; Microbial Sensitivity Tests ; Patient surveillance ; Penicillins - pharmacology ; Staphylococcal Infections - epidemiology ; Staphylococcal Infections - microbiology ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Staphylococcus aureus ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - genetics ; Switzerland ; Switzerland - epidemiology ; University hospitals</subject><ispartof>Clinical infectious diseases, 1999-12, Vol.29 (6), p.1512-1518</ispartof><rights>Copyright 1999 The Infectious Diseases Society of America</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-51a5029b00cad2b7cc85166a9e29aa83ab32725e53a7a932aacd1b6b6c7d4c513</citedby><cites>FETCH-LOGICAL-c426t-51a5029b00cad2b7cc85166a9e29aa83ab32725e53a7a932aacd1b6b6c7d4c513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4482064$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4482064$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,781,785,804,27929,27930,58022,58255</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1250916$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10585805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blanc, D. S.</creatorcontrib><creatorcontrib>Petignat, C.</creatorcontrib><creatorcontrib>Moreillon, P.</creatorcontrib><creatorcontrib>Entenza, J. M.</creatorcontrib><creatorcontrib>Eisenring, M.-C.</creatorcontrib><creatorcontrib>Kleiber, H.</creatorcontrib><creatorcontrib>Wenger, A.</creatorcontrib><creatorcontrib>Troillet, N.</creatorcontrib><creatorcontrib>Blanc, C.-H.</creatorcontrib><creatorcontrib>Francioli, P.</creatorcontrib><title>Unusual Spread of a Penicillin-Susceptible Methicillin-Resistant Staphylococcus aureus Clone in a Geographic Area of Low Incidence</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><description>We describe the unusual spread of a penicillin-susceptible methicillin-resistant Staphylococcus aureus (MRSA) clone in hospitals in western Switzerland, where the incidence of MRSA is usually low. During a 2-year period, this clone had been responsible for several outbreaks and had been isolated from >156 persons in 21 institutions. Molecular typing by pulsed-field gel electrophoresis (PFGE) demonstrated that all of these isolates belonged to the same clone. In 1 of the outbreaks, involving 30 cases, the clone was responsible for at least 17 secondary cases. In contrast, during the period of the latter outbreak, 9 other patients harboring different MRSA strains, as assessed by PFGE, were hospitalized in the same wards, but no secondary cases occurred. These observations suggest that this clone, compared with other MRSA strains, had some intrinsic factor(s) that contributed to its ability to disseminate and could thus be considered epidemic.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Clinical Articles</subject><subject>Cross Infection - microbiology</subject><subject>Disease Outbreaks</subject><subject>DNA, Bacterial - analysis</subject><subject>Electrophoresis, Gel, Pulsed-Field</subject><subject>Epidemics</subject><subject>Gels</subject><subject>Geography</subject><subject>Hospital admissions</subject><subject>Hospitalization</subject><subject>Hospitals, University</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Methicillin Resistance</subject><subject>Methicillin resistant staphylococcus aureus</subject><subject>Microbial Sensitivity Tests</subject><subject>Patient surveillance</subject><subject>Penicillins - pharmacology</subject><subject>Staphylococcal Infections - epidemiology</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Staphylococcus aureus - genetics</subject><subject>Switzerland</subject><subject>Switzerland - epidemiology</subject><subject>University hospitals</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhiMEoh_AL0DIB9RbwB-xYx_bFWyLFlGxFCEu1sTxUhevHexE0Cu_HK-ytNw4zWjeR-9o5q2qZwS_IliK14wwTumD6pBw1taCK_Kw9JjLupFMHlRHOd9gTIjE_HF1sBN4aQ-r31dhyhN4tB6ShR7FDQJ0aYMzznsX6vWUjR1G13mL3tvx-u_8o80ujxBGtB5huL710URjpoxgSraUhY_BIheK29LGb6kwzqDTsmO3YhV_ootgXG-DsU-qRxvw2T7d1-Pq6u2bT4vzevVhebE4XdWmoWKsOQGOqeowNtDTrjVGciIEKEsVgGTQMdpSbjmDFhSjAKYnneiEafvGcMKOq5PZd0jxx2TzqLeuHOc9BBunrIViDSPk_yBppaRCqXvQpJhzshs9JLeFdKsJ1rtY9BxLAV_sHadua_t_sDmHArzcA5AN-E2C8p18z1GOFREFez5jN3mM6U5uGkmxaIpcz3KJxv66kyF916JlLdfnX77qxef15Zl6t9Sc_QFvKa0w</recordid><startdate>19991201</startdate><enddate>19991201</enddate><creator>Blanc, D. S.</creator><creator>Petignat, C.</creator><creator>Moreillon, P.</creator><creator>Entenza, J. M.</creator><creator>Eisenring, M.-C.</creator><creator>Kleiber, H.</creator><creator>Wenger, A.</creator><creator>Troillet, N.</creator><creator>Blanc, C.-H.</creator><creator>Francioli, P.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19991201</creationdate><title>Unusual Spread of a Penicillin-Susceptible Methicillin-Resistant Staphylococcus aureus Clone in a Geographic Area of Low Incidence</title><author>Blanc, D. S. ; Petignat, C. ; Moreillon, P. ; Entenza, J. 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S.</creatorcontrib><creatorcontrib>Petignat, C.</creatorcontrib><creatorcontrib>Moreillon, P.</creatorcontrib><creatorcontrib>Entenza, J. M.</creatorcontrib><creatorcontrib>Eisenring, M.-C.</creatorcontrib><creatorcontrib>Kleiber, H.</creatorcontrib><creatorcontrib>Wenger, A.</creatorcontrib><creatorcontrib>Troillet, N.</creatorcontrib><creatorcontrib>Blanc, C.-H.</creatorcontrib><creatorcontrib>Francioli, P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blanc, D. S.</au><au>Petignat, C.</au><au>Moreillon, P.</au><au>Entenza, J. M.</au><au>Eisenring, M.-C.</au><au>Kleiber, H.</au><au>Wenger, A.</au><au>Troillet, N.</au><au>Blanc, C.-H.</au><au>Francioli, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unusual Spread of a Penicillin-Susceptible Methicillin-Resistant Staphylococcus aureus Clone in a Geographic Area of Low Incidence</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clinical Infectious Diseases</addtitle><date>1999-12-01</date><risdate>1999</risdate><volume>29</volume><issue>6</issue><spage>1512</spage><epage>1518</epage><pages>1512-1518</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>We describe the unusual spread of a penicillin-susceptible methicillin-resistant Staphylococcus aureus (MRSA) clone in hospitals in western Switzerland, where the incidence of MRSA is usually low. During a 2-year period, this clone had been responsible for several outbreaks and had been isolated from >156 persons in 21 institutions. Molecular typing by pulsed-field gel electrophoresis (PFGE) demonstrated that all of these isolates belonged to the same clone. In 1 of the outbreaks, involving 30 cases, the clone was responsible for at least 17 secondary cases. In contrast, during the period of the latter outbreak, 9 other patients harboring different MRSA strains, as assessed by PFGE, were hospitalized in the same wards, but no secondary cases occurred. These observations suggest that this clone, compared with other MRSA strains, had some intrinsic factor(s) that contributed to its ability to disseminate and could thus be considered epidemic.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>10585805</pmid><doi>10.1086/313522</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical infectious diseases, 1999-12, Vol.29 (6), p.1512-1518 |
| issn | 1058-4838 1537-6591 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Anti-Bacterial Agents - pharmacology Antibiotics Bacterial diseases Biological and medical sciences Clinical Articles Cross Infection - microbiology Disease Outbreaks DNA, Bacterial - analysis Electrophoresis, Gel, Pulsed-Field Epidemics Gels Geography Hospital admissions Hospitalization Hospitals, University Human bacterial diseases Humans Incidence Infections Infectious diseases Medical sciences Methicillin Resistance Methicillin resistant staphylococcus aureus Microbial Sensitivity Tests Patient surveillance Penicillins - pharmacology Staphylococcal Infections - epidemiology Staphylococcal Infections - microbiology Staphylococcal infections, streptococcal infections, pneumococcal infections Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - genetics Switzerland Switzerland - epidemiology University hospitals |
| title | Unusual Spread of a Penicillin-Susceptible Methicillin-Resistant Staphylococcus aureus Clone in a Geographic Area of Low Incidence |
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