Hu Antigen Specificities of ANNA-I Autoantibodies in Paraneoplastic Neurological Disease

Despite a broad clinical spectrum, paraneoplastic enecephalomyelitis/sensory neuronopathy (PEM/SSN) is characterized by the presence of a common autoantibody, referred to as anti-Hu or type I anti-neuronal nuclear antibody (ANNA-1). The target of these antibodies is a family of four Hu antigens: thr...

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Veröffentlicht in:	Journal of autoimmunity 1999-12, Vol.13 (4), p.435-443
Hauptverfasser:	King, P.H, Redden, D, Palmgren, J.S, Nabors, L.B, Lennon, V.A
Format:	Artikel
Sprache:	eng
Schlagworte:	AHu antigen Antigens, Surface - genetics Antigens, Surface - immunology Autoantibodies - blood Autoantibodies - immunology Biological and medical sciences ELAV Proteins ELAV-Like Protein 1 ELAV-Like Protein 2 ELAV-Like Protein 3 ELAV-Like Protein 4 Enzyme-Linked Immunosorbent Assay - methods Hel-N1, HuC, HuD, HuR, RNA-binding proteins Humans Medical sciences Nerve Tissue Proteins - genetics Nerve Tissue Proteins - immunology Nervous system involvement in other diseases. Miscellaneous Neurology Paraneoplastic Syndromes, Nervous System - blood Paraneoplastic Syndromes, Nervous System - immunology Paraneoplastic Syndromes, Nervous System - physiopathology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology RNA-Binding Proteins - genetics RNA-Binding Proteins - immunology
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