Persistence of depressive symptoms and cardiovascular death among patients with affective disorder

Studies of both community and clinical samples have associated depressive symptoms with risks for subsequent cardiovascular morbidity and mortality. Because the physiological mechanisms thought to underlie this link would be cumulative in their effects, the following analyses tested the prediction t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Psychosomatic medicine 1999-11, Vol.61 (6), p.755-761
Hauptverfasser: Coryell, W, Turvey, C, Leon, A, Maser, J D, Solomon, D, Endicott, J, Mueller, T, Keller, M
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 761
container_issue 6
container_start_page 755
container_title Psychosomatic medicine
container_volume 61
creator Coryell, W
Turvey, C
Leon, A
Maser, J D
Solomon, D
Endicott, J
Mueller, T
Keller, M
description Studies of both community and clinical samples have associated depressive symptoms with risks for subsequent cardiovascular morbidity and mortality. Because the physiological mechanisms thought to underlie this link would be cumulative in their effects, the following analyses tested the prediction that risks for cardiovascular death would increase in proportion to the persistence of depressive symptoms in a long-term follow-up. Baseline assessment was performed as patients sought treatment for major depressive disorder, mania, or schizo-affective disorder. Follow-up evaluations occurred semiannually for the next 5 years and annually thereafter. The 903 patients described, observed for a mean of 11.0 years (SD = 5.2 years), were divided into thirds according to the proportion of follow-up weeks in episodes of major depressive disorder, schizoaffective disorder, or intermittent depressive disorder. The resulting groups were then compared by cumulative risks of cardiovascular death. Patients whose depressive symptoms were the most persistent were no more likely to die of cardiovascular causes than were those with the fewest weeks ill. A regression analysis showed that older age and the presence of cardiovascular disease at baseline, but not the subsequent chronicity of depressive symptoms, predicted cardiovascular death. The physiological concomitants of depressive illness apparently do not promote cardiovascular mortality in a cumulative manner. Efforts should be directed toward identification of risk factors common to both lifetime depressive symptoms and cardiovascular morbidity.
doi_str_mv 10.1097/00006842-199911000-00006
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69342749</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69342749</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-cbda4ce046fe28d59ded166098bddca9d69908828278e2dea88d1878fddfed972</originalsourceid><addsrcrecordid>eNpNkE1PwzAMhnMAsTH4CygnboUk7drkiCa-pElwgHOVxg4U9Ys4G9q_p6MD4YvlR-9rWy9jXIorKUxxLcbKdaYSaYyRcpySH3TE5kKkaZLKIpuxU6KPkWYmVSdsJsXSpLnK56x6xkA1Rewc8t5zwCEgUb1FTrt2iH1L3HbAnQ1Q91tLbtPYMMpsfOe27bs3PthYYxeJf9V75j26uPdDTX0ADGfs2NuG8PzQF-z17vZl9ZCsn-4fVzfrxKVSxsRVYDOHIss9Kg1LAwgyz4XRFYCzBnJjhNZKq0KjGh_QGqQutAfwCKZQC3Y57R1C_7lBimVbk8OmsR32Gypzk2aqyMwo1JPQhZ4ooC-HULc27Eopyn2m5W-m5V-mExqtF4cbm6pF-GecAlXfsCN3Dg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69342749</pqid></control><display><type>article</type><title>Persistence of depressive symptoms and cardiovascular death among patients with affective disorder</title><source>MEDLINE</source><creator>Coryell, W ; Turvey, C ; Leon, A ; Maser, J D ; Solomon, D ; Endicott, J ; Mueller, T ; Keller, M</creator><creatorcontrib>Coryell, W ; Turvey, C ; Leon, A ; Maser, J D ; Solomon, D ; Endicott, J ; Mueller, T ; Keller, M</creatorcontrib><description>Studies of both community and clinical samples have associated depressive symptoms with risks for subsequent cardiovascular morbidity and mortality. Because the physiological mechanisms thought to underlie this link would be cumulative in their effects, the following analyses tested the prediction that risks for cardiovascular death would increase in proportion to the persistence of depressive symptoms in a long-term follow-up. Baseline assessment was performed as patients sought treatment for major depressive disorder, mania, or schizo-affective disorder. Follow-up evaluations occurred semiannually for the next 5 years and annually thereafter. The 903 patients described, observed for a mean of 11.0 years (SD = 5.2 years), were divided into thirds according to the proportion of follow-up weeks in episodes of major depressive disorder, schizoaffective disorder, or intermittent depressive disorder. The resulting groups were then compared by cumulative risks of cardiovascular death. Patients whose depressive symptoms were the most persistent were no more likely to die of cardiovascular causes than were those with the fewest weeks ill. A regression analysis showed that older age and the presence of cardiovascular disease at baseline, but not the subsequent chronicity of depressive symptoms, predicted cardiovascular death. The physiological concomitants of depressive illness apparently do not promote cardiovascular mortality in a cumulative manner. Efforts should be directed toward identification of risk factors common to both lifetime depressive symptoms and cardiovascular morbidity.</description><identifier>ISSN: 0033-3174</identifier><identifier>DOI: 10.1097/00006842-199911000-00006</identifier><identifier>PMID: 10593626</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Age Distribution ; Bipolar Disorder - complications ; Bipolar Disorder - mortality ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - mortality ; Cardiovascular Diseases - psychology ; Chronic Disease ; Depressive Disorder, Major - complications ; Depressive Disorder, Major - mortality ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Population Surveillance ; Prospective Studies ; Psychotic Disorders - complications ; Psychotic Disorders - mortality ; Risk Factors ; Sex Distribution ; Survival Analysis ; United States - epidemiology</subject><ispartof>Psychosomatic medicine, 1999-11, Vol.61 (6), p.755-761</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-cbda4ce046fe28d59ded166098bddca9d69908828278e2dea88d1878fddfed972</citedby><cites>FETCH-LOGICAL-c311t-cbda4ce046fe28d59ded166098bddca9d69908828278e2dea88d1878fddfed972</cites></display><links><openurl>$$Topenurl_article</openurl><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10593626$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coryell, W</creatorcontrib><creatorcontrib>Turvey, C</creatorcontrib><creatorcontrib>Leon, A</creatorcontrib><creatorcontrib>Maser, J D</creatorcontrib><creatorcontrib>Solomon, D</creatorcontrib><creatorcontrib>Endicott, J</creatorcontrib><creatorcontrib>Mueller, T</creatorcontrib><creatorcontrib>Keller, M</creatorcontrib><title>Persistence of depressive symptoms and cardiovascular death among patients with affective disorder</title><title>Psychosomatic medicine</title><addtitle>Psychosom Med</addtitle><description>Studies of both community and clinical samples have associated depressive symptoms with risks for subsequent cardiovascular morbidity and mortality. Because the physiological mechanisms thought to underlie this link would be cumulative in their effects, the following analyses tested the prediction that risks for cardiovascular death would increase in proportion to the persistence of depressive symptoms in a long-term follow-up. Baseline assessment was performed as patients sought treatment for major depressive disorder, mania, or schizo-affective disorder. Follow-up evaluations occurred semiannually for the next 5 years and annually thereafter. The 903 patients described, observed for a mean of 11.0 years (SD = 5.2 years), were divided into thirds according to the proportion of follow-up weeks in episodes of major depressive disorder, schizoaffective disorder, or intermittent depressive disorder. The resulting groups were then compared by cumulative risks of cardiovascular death. Patients whose depressive symptoms were the most persistent were no more likely to die of cardiovascular causes than were those with the fewest weeks ill. A regression analysis showed that older age and the presence of cardiovascular disease at baseline, but not the subsequent chronicity of depressive symptoms, predicted cardiovascular death. The physiological concomitants of depressive illness apparently do not promote cardiovascular mortality in a cumulative manner. Efforts should be directed toward identification of risk factors common to both lifetime depressive symptoms and cardiovascular morbidity.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Bipolar Disorder - complications</subject><subject>Bipolar Disorder - mortality</subject><subject>Cardiovascular Diseases - complications</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Cardiovascular Diseases - psychology</subject><subject>Chronic Disease</subject><subject>Depressive Disorder, Major - complications</subject><subject>Depressive Disorder, Major - mortality</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Population Surveillance</subject><subject>Prospective Studies</subject><subject>Psychotic Disorders - complications</subject><subject>Psychotic Disorders - mortality</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>Survival Analysis</subject><subject>United States - epidemiology</subject><issn>0033-3174</issn><fulltext>false</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1PwzAMhnMAsTH4CygnboUk7drkiCa-pElwgHOVxg4U9Ys4G9q_p6MD4YvlR-9rWy9jXIorKUxxLcbKdaYSaYyRcpySH3TE5kKkaZLKIpuxU6KPkWYmVSdsJsXSpLnK56x6xkA1Rewc8t5zwCEgUb1FTrt2iH1L3HbAnQ1Q91tLbtPYMMpsfOe27bs3PthYYxeJf9V75j26uPdDTX0ADGfs2NuG8PzQF-z17vZl9ZCsn-4fVzfrxKVSxsRVYDOHIss9Kg1LAwgyz4XRFYCzBnJjhNZKq0KjGh_QGqQutAfwCKZQC3Y57R1C_7lBimVbk8OmsR32Gypzk2aqyMwo1JPQhZ4ooC-HULc27Eopyn2m5W-m5V-mExqtF4cbm6pF-GecAlXfsCN3Dg</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>Coryell, W</creator><creator>Turvey, C</creator><creator>Leon, A</creator><creator>Maser, J D</creator><creator>Solomon, D</creator><creator>Endicott, J</creator><creator>Mueller, T</creator><creator>Keller, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991101</creationdate><title>Persistence of depressive symptoms and cardiovascular death among patients with affective disorder</title><author>Coryell, W ; Turvey, C ; Leon, A ; Maser, J D ; Solomon, D ; Endicott, J ; Mueller, T ; Keller, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-cbda4ce046fe28d59ded166098bddca9d69908828278e2dea88d1878fddfed972</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>Bipolar Disorder - complications</topic><topic>Bipolar Disorder - mortality</topic><topic>Cardiovascular Diseases - complications</topic><topic>Cardiovascular Diseases - mortality</topic><topic>Cardiovascular Diseases - psychology</topic><topic>Chronic Disease</topic><topic>Depressive Disorder, Major - complications</topic><topic>Depressive Disorder, Major - mortality</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Population Surveillance</topic><topic>Prospective Studies</topic><topic>Psychotic Disorders - complications</topic><topic>Psychotic Disorders - mortality</topic><topic>Risk Factors</topic><topic>Sex Distribution</topic><topic>Survival Analysis</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><creatorcontrib>Coryell, W</creatorcontrib><creatorcontrib>Turvey, C</creatorcontrib><creatorcontrib>Leon, A</creatorcontrib><creatorcontrib>Maser, J D</creatorcontrib><creatorcontrib>Solomon, D</creatorcontrib><creatorcontrib>Endicott, J</creatorcontrib><creatorcontrib>Mueller, T</creatorcontrib><creatorcontrib>Keller, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychosomatic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>no_fulltext</fulltext></delivery><addata><au>Coryell, W</au><au>Turvey, C</au><au>Leon, A</au><au>Maser, J D</au><au>Solomon, D</au><au>Endicott, J</au><au>Mueller, T</au><au>Keller, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Persistence of depressive symptoms and cardiovascular death among patients with affective disorder</atitle><jtitle>Psychosomatic medicine</jtitle><addtitle>Psychosom Med</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>61</volume><issue>6</issue><spage>755</spage><epage>761</epage><pages>755-761</pages><issn>0033-3174</issn><abstract>Studies of both community and clinical samples have associated depressive symptoms with risks for subsequent cardiovascular morbidity and mortality. Because the physiological mechanisms thought to underlie this link would be cumulative in their effects, the following analyses tested the prediction that risks for cardiovascular death would increase in proportion to the persistence of depressive symptoms in a long-term follow-up. Baseline assessment was performed as patients sought treatment for major depressive disorder, mania, or schizo-affective disorder. Follow-up evaluations occurred semiannually for the next 5 years and annually thereafter. The 903 patients described, observed for a mean of 11.0 years (SD = 5.2 years), were divided into thirds according to the proportion of follow-up weeks in episodes of major depressive disorder, schizoaffective disorder, or intermittent depressive disorder. The resulting groups were then compared by cumulative risks of cardiovascular death. Patients whose depressive symptoms were the most persistent were no more likely to die of cardiovascular causes than were those with the fewest weeks ill. A regression analysis showed that older age and the presence of cardiovascular disease at baseline, but not the subsequent chronicity of depressive symptoms, predicted cardiovascular death. The physiological concomitants of depressive illness apparently do not promote cardiovascular mortality in a cumulative manner. Efforts should be directed toward identification of risk factors common to both lifetime depressive symptoms and cardiovascular morbidity.</abstract><cop>United States</cop><pmid>10593626</pmid><doi>10.1097/00006842-199911000-00006</doi><tpages>7</tpages></addata></record>
fulltext no_fulltext
identifier ISSN: 0033-3174
ispartof Psychosomatic medicine, 1999-11, Vol.61 (6), p.755-761
issn 0033-3174
language eng
recordid cdi_proquest_miscellaneous_69342749
source MEDLINE
subjects Adult
Age Distribution
Bipolar Disorder - complications
Bipolar Disorder - mortality
Cardiovascular Diseases - complications
Cardiovascular Diseases - mortality
Cardiovascular Diseases - psychology
Chronic Disease
Depressive Disorder, Major - complications
Depressive Disorder, Major - mortality
Female
Follow-Up Studies
Humans
Male
Middle Aged
Population Surveillance
Prospective Studies
Psychotic Disorders - complications
Psychotic Disorders - mortality
Risk Factors
Sex Distribution
Survival Analysis
United States - epidemiology
title Persistence of depressive symptoms and cardiovascular death among patients with affective disorder
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T21%3A08%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Persistence%20of%20depressive%20symptoms%20and%20cardiovascular%20death%20among%20patients%20with%20affective%20disorder&rft.jtitle=Psychosomatic%20medicine&rft.au=Coryell,%20W&rft.date=1999-11-01&rft.volume=61&rft.issue=6&rft.spage=755&rft.epage=761&rft.pages=755-761&rft.issn=0033-3174&rft_id=info:doi/10.1097/00006842-199911000-00006&rft_dat=%3Cproquest_cross%3E69342749%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69342749&rft_id=info:pmid/10593626&rfr_iscdi=true