Molecular Clip and Tweezer Introduce New Mechanisms of Enzyme Inhibition

Artificial molecular clips and tweezers, designed for cofactor and amino acid recognition, are able to inhibit the enzymatic activity of alcohol dehydrogenase (ADH). IC50 values and kinetic investigations point to two different new mechanisms of interference with the NAD+-dependent oxidoreductase: W...

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Veröffentlicht in:	Journal of the American Chemical Society 2008-07, Vol.130 (30), p.9824-9828
Hauptverfasser:	Talbiersky, Peter, Bastkowski, Frank, Klärner, Frank-Gerrit, Schrader, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Dehydrogenase - antagonists & inhibitors Alcohol Dehydrogenase - chemistry Alcohol Dehydrogenase - metabolism Circular Dichroism Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Enzyme Inhibitors - pharmacology Kinetics Lysine - chemistry Molecular Conformation NAD - chemistry NAD - metabolism Organophosphates - chemistry Organophosphates - metabolism Organophosphates - pharmacology Polycyclic Aromatic Hydrocarbons - chemistry Polycyclic Aromatic Hydrocarbons - metabolism Polycyclic Aromatic Hydrocarbons - pharmacology
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