Visceral Leishmaniasis (Kala-azar) in Solid Organ Transplantation: Report of Five Cases and Review
Visceral leishmaniasis is an infectious disease that occurs only rarely in recipients of solid organ grafts but is associated with an elevated mortality rate despite proper treatment. We report five cases diagnosed in our hospital. All the patients were men aged 30 to 60 years who had undergone kidn...
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Veröffentlicht in: | Clinical infectious diseases 1999-10, Vol.29 (4), p.918-921 |
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creator | Hernández-Pérez, J. Yebra-Bango, M. Jiménez-Martínez, E. Sanz-Moreno, C. Cuervas-Mons, V. Pulpón, L. Alonso Ramos-Martínez, A. Fernández-Fernández, J. |
description | Visceral leishmaniasis is an infectious disease that occurs only rarely in recipients of solid organ grafts but is associated with an elevated mortality rate despite proper treatment. We report five cases diagnosed in our hospital. All the patients were men aged 30 to 60 years who had undergone kidney transplantation (3 patients), heart transplantation (1), or liver transplantation (1). Three of the patients died, one had multiple recurrences, and one developed post-kala-azar cutaneous leishmaniasis. We review the clinical features, treatments, and outcomes of 26 previously reported cases, pointing out the lower cure rate associated with human immunodeficiency virus infection. |
doi_str_mv | 10.1086/520457 |
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Alonso</creatorcontrib><creatorcontrib>Ramos-Martínez, A.</creatorcontrib><creatorcontrib>Fernández-Fernández, J.</creatorcontrib><title>Visceral Leishmaniasis (Kala-azar) in Solid Organ Transplantation: Report of Five Cases and Review</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><description>Visceral leishmaniasis is an infectious disease that occurs only rarely in recipients of solid organ grafts but is associated with an elevated mortality rate despite proper treatment. We report five cases diagnosed in our hospital. All the patients were men aged 30 to 60 years who had undergone kidney transplantation (3 patients), heart transplantation (1), or liver transplantation (1). Three of the patients died, one had multiple recurrences, and one developed post-kala-azar cutaneous leishmaniasis. We review the clinical features, treatments, and outcomes of 26 previously reported cases, pointing out the lower cure rate associated with human immunodeficiency virus infection.</description><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Body weight</subject><subject>Fever</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Kidneys</subject><subject>Leishmaniasis</subject><subject>Leishmaniasis, Visceral - diagnosis</subject><subject>Leishmaniasis, Visceral - drug therapy</subject><subject>Leishmaniasis, Visceral - etiology</subject><subject>Leshmaniasis</subject><subject>Liver</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Organ transplantation</subject><subject>Organ Transplantation - adverse effects</subject><subject>Parasitic diseases</subject><subject>Protozoal diseases</subject><subject>Splenomegaly</subject><subject>Transplantation</subject><subject>Visceral leishmaniasis</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkN9r1EAQxxdR7A_bv0DKPkjRh-j-yGY3vslhrXhQ0PY4-rJMNhO7NZecO7lq_evNkaPty8zA58Mw82XsWIr3Urjig1EiN_YZ25dG26wwpXw-zsK4LHfa7bEDolshpHTCvGR7W1CWUuyzahEpYIKWzzHSzQq6CBSJv_0GLWTwD9I7Hjv-o29jzS_ST-j4ZYKO1i10Awyx7z7y77ju08D7hp_FO-QzICQOXT2Cu4h_XrEXDbSER7t-yK7OPl_OzrP5xZevs0_zLOjSDJmDwlqlyrqSRoWxmFoCKmvrKq-cEmXpmoAgVIEhdzXaHE0BtVNBVbIB0IfsdNq7Tv3vDdLgV9vf2vFS7Dfki1LnSgv3KIbUEyVs_DrFFaR7L4XfpumnNEfxZLdxU62wfqJN8Y3Cm50AFKBtxmRCpEdPOi20HLXXk3ZLQ58ecJ4XUqjtPdmEIw349wFD-uULq63x58tr79RyKRcL5Y3-D7Ltk0o</recordid><startdate>19991001</startdate><enddate>19991001</enddate><creator>Hernández-Pérez, J.</creator><creator>Yebra-Bango, M.</creator><creator>Jiménez-Martínez, E.</creator><creator>Sanz-Moreno, C.</creator><creator>Cuervas-Mons, V.</creator><creator>Pulpón, L. Alonso</creator><creator>Ramos-Martínez, A.</creator><creator>Fernández-Fernández, J.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991001</creationdate><title>Visceral Leishmaniasis (Kala-azar) in Solid Organ Transplantation: Report of Five Cases and Review</title><author>Hernández-Pérez, J. ; Yebra-Bango, M. ; Jiménez-Martínez, E. ; Sanz-Moreno, C. ; Cuervas-Mons, V. ; Pulpón, L. 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Alonso</au><au>Ramos-Martínez, A.</au><au>Fernández-Fernández, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Visceral Leishmaniasis (Kala-azar) in Solid Organ Transplantation: Report of Five Cases and Review</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clinical Infectious Diseases</addtitle><date>1999-10-01</date><risdate>1999</risdate><volume>29</volume><issue>4</issue><spage>918</spage><epage>921</epage><pages>918-921</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>Visceral leishmaniasis is an infectious disease that occurs only rarely in recipients of solid organ grafts but is associated with an elevated mortality rate despite proper treatment. We report five cases diagnosed in our hospital. All the patients were men aged 30 to 60 years who had undergone kidney transplantation (3 patients), heart transplantation (1), or liver transplantation (1). 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subjects | Adult AIDS/HIV Biological and medical sciences Body weight Fever Human protozoal diseases Humans Infections Infectious diseases Kidneys Leishmaniasis Leishmaniasis, Visceral - diagnosis Leishmaniasis, Visceral - drug therapy Leishmaniasis, Visceral - etiology Leshmaniasis Liver Male Medical sciences Middle Aged Organ transplantation Organ Transplantation - adverse effects Parasitic diseases Protozoal diseases Splenomegaly Transplantation Visceral leishmaniasis |
title | Visceral Leishmaniasis (Kala-azar) in Solid Organ Transplantation: Report of Five Cases and Review |
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