JNK-dependent CaMK pathway restrains the reversion of committed cells during osteoclast differentiation

Osteoclastogenesis involves the commitment of macrophage-lineage precursors to tartrate-resistant acid phosphatase-positive (TRAP⁺) mononuclear pre-osteoclasts (pOCs) and subsequent fusion of pOCs to form multinuclear mature osteoclasts. Despite many studies on osteoclast differentiation, little is...

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Veröffentlicht in:	Journal of cell science 2008-08, Vol.121 (15), p.2555-2564
Hauptverfasser:	Chang, Eun-Ju, Ha, Jeongim, Huang, Hao, Kim, Hyung Joon, Woo, Jung Hoon, Lee, Youngkyun, Lee, Zang Hee, Kim, Ju Han, Kim, Hong-Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase - genetics Acid Phosphatase - metabolism Animals Bone Marrow Cells - metabolism Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell Differentiation Cells, Cultured Humans Isoenzymes - genetics Isoenzymes - metabolism JNK Mitogen-Activated Protein Kinases - metabolism Mice Mice, Inbred ICR Models, Biological NFATC Transcription Factors - metabolism Osteoclasts - cytology Osteoclasts - enzymology Osteoclasts - metabolism Proto-Oncogene Proteins c-jun - metabolism RANK Ligand - metabolism Signal Transduction Tartrate-Resistant Acid Phosphatase
Online-Zugang:	Volltext
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