A Novel Variant in the Platelet Endothelial Aggregation Receptor-1 Gene Is Associated With Increased Platelet Aggregability

OBJECTIVE—Platelet endothelial aggregation receptor-1 (PEAR1) is a recently identified platelet transmembrane protein that becomes activated by platelet contact. We looked for novel genetic variants in PEAR1 and studied their association with agonist-induced native platelet aggregation and with the...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2008-08, Vol.28 (8), p.1484-1490
Hauptverfasser:	Herrera-Galeano, J Enrique, Becker, Diane M, Wilson, Alexander F, Yanek, Lisa R, Bray, Paul, Vaidya, Dhananjay, Faraday, Nauder, Becker, Lewis C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult African Americans Aged Aspirin - pharmacology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood coagulation. Blood cells Cardiology. Vascular system Coronary Artery Disease - genetics Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous European Continental Ancestry Group Female Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease - genetics Genotype Humans Male Medical sciences Middle Aged Molecular and cellular biology Platelet Platelet Aggregation - drug effects Platelet Aggregation - genetics Platelet Aggregation Inhibitors - pharmacology Polymorphism, Single Nucleotide - genetics Receptors, Cell Surface - genetics
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