The chromosome glue gets a little stickier
Since their discovery, the cohesin proteins have been intensely studied in multiple model systems to determine the mechanism of chromosome cohesion. Recent studies have demonstrated that cohesin is much more than a molecular glue that holds chromosomes together in mitosis. Indeed, cohesin performs c...
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| Veröffentlicht in: | Trends in genetics 2008-08, Vol.24 (8), p.382-389 |
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| creator | McNairn, Adrian J Gerton, Jennifer L |
| description | Since their discovery, the cohesin proteins have been intensely studied in multiple model systems to determine the mechanism of chromosome cohesion. Recent studies have demonstrated that cohesin is much more than a molecular glue that holds chromosomes together in mitosis. Indeed, cohesin performs critical roles in gene regulation, possibly through the formation of higher-order chromatin structure. Moreover, this newly appreciated role is necessary for proper development in metazoan species, with mutations in the cohesin pathway resulting in human developmental disorders. |
| doi_str_mv | 10.1016/j.tig.2008.06.002 |
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| ispartof | Trends in genetics, 2008-08, Vol.24 (8), p.382-389 |
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| language | eng |
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| subjects | Adhesiveness Animals Biological and medical sciences Cell Cycle - genetics Cell Cycle - physiology Cell Cycle Proteins - genetics Cell Cycle Proteins - physiology Cell Proliferation Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - physiology Chromosomes - genetics Chromosomes - physiology Cohesins Fundamental and applied biological sciences. Psychology Gene Expression Regulation Humans Medical Education Metazoa Models, Biological Molecular and cellular biology Molecular genetics Transcription. Transcription factor. Splicing. Rna processing |
| title | The chromosome glue gets a little stickier |
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