Relation between T-cell responses to glutamate decarboxylase and coxsackievirus B4 in patients with insulin-dependent diabetes mellitus

Background: the role of enteroviruses has been implicated in the etiology of insulin-dependent diabetes mellitus (IDDM). A possible connection between glutamate decarboxylase (GAD) autoimmunity and enterovirus infections in IDDM has been suggested to be based on a homology region between GAD and the...

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Veröffentlicht in:	Journal of clinical virology 1999-10, Vol.14 (2), p.95-105
Hauptverfasser:	Klemetti, P, Hyöty, H, Roivainen, M, Ilonen, J, Savola, K, Knip, M, Åkerblom, H.K, Vaarala, O
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Alleles Analysis of the immune response. Humoral and cellular immunity Autoimmune Diseases - diagnosis Autoimmune Diseases - immunology Biological and medical sciences Cell interactions Cells, Cultured Child Child, Preschool Coxsackievirus Infections - complications Coxsackievirus Infections - diagnosis Coxsackievirus Infections - immunology Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - virology Enterovirus Enterovirus B, Human - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology GAD GADA Glutamate Decarboxylase - immunology HLA HLA-DQ Antigens - genetics HLA-DQ beta-Chains Human viral diseases Humans Immunobiology Infant Infectious diseases Medical sciences Miscellaneous Poliovirus - immunology T-lymphocyte T-Lymphocytes - immunology Tetanus Toxoid - immunology Tumor Cells, Cultured Viral diseases
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