Role of an ABC importer in mycobacterial drug resistance

Phosphate specific transporter (Pst) in bacteria is involved in phosphate transport. Pst is a multisubunit system which belongs to the ABC family of transporters. The import function of this transporter is known to be operative at media phosphate concentrations below the millimolar range. However, w...

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Veröffentlicht in:	Bioscience reports 1999-08, Vol.19 (4), p.293-300
Hauptverfasser:	Chakraborti, P K, Bhatt, K, Banerjee, S K, Misra, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases Amino Acid Sequence Anti-Infective Agents - metabolism ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Bacterial Proteins Blotting, Southern Drug Resistance, Microbial - genetics Fluoroquinolones Molecular Sequence Data Mycobacterium smegmatis - genetics Mycobacterium smegmatis - metabolism Open Reading Frames Phosphates - pharmacokinetics Polymerase Chain Reaction Sequence Homology, Amino Acid Time Factors
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Zusammenfassung:	Phosphate specific transporter (Pst) in bacteria is involved in phosphate transport. Pst is a multisubunit system which belongs to the ABC family of transporters. The import function of this transporter is known to be operative at media phosphate concentrations below the millimolar range. However, we found amplification of this transporter in a laboratory generated ciprofloxacin resistant Mycobacterium smegmatis colony (CIPr) which was grown in a condition when phosphate scavenging function of this operon was inoperative. Our results therefore argue the role of this ABC importer in conferring high level of fluoroquinolone resistance in CIPr.
ISSN:	0144-8463 1573-4935
DOI:	10.1023/A:1020598324663