Hypoallergenicity and Effects on Growth and Tolerance of a New Amino Acid-Based Formula with Docosahexaenoic Acid and Arachidonic Acid
Objective In study 1, to compare the effect on growth in healthy infants of a new amino acid–based formula (AAF) and a control extensively hydrolyzed formula (EHF), with both docosahexaenoic acid (DHA) and arachidonic acid (ARA) at levels similar to those in human milk worldwide. In study 2, to eval...
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| Veröffentlicht in: | The Journal of pediatrics 2008-08, Vol.153 (2), p.266-271 |
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| container_title | The Journal of pediatrics |
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| creator | Burks, Wesley, MD Jones, Stacie M., MD Berseth, Carol Lynn, MD Harris, Cheryl, MS Sampson, Hugh A., MD Scalabrin, Deolinda M.F., MD, PhD |
| description | Objective In study 1, to compare the effect on growth in healthy infants of a new amino acid–based formula (AAF) and a control extensively hydrolyzed formula (EHF), with both docosahexaenoic acid (DHA) and arachidonic acid (ARA) at levels similar to those in human milk worldwide. In study 2, to evaluate the hypoallergenicity of this new AAF in infants and children with confirmed cow's milk allergy (CMA). Study design In study 1, a total of 165 healthy, full-term, formula-fed infants randomly received the new AAF or control formula. Anthropometric measurements, tolerance, and adverse events were recorded throughout the study. Plasma amino acid profiles were evaluated in a subset of the infants. In study 2, the hypoallergenicity of the new AAF was evaluated in 32 infants and children using a double-blind, placebo-controlled food challenge; an open challenge; and a 7-day feeding. Results In study 1, overall growth, tolerance, and safety outcomes were similar in both groups. In study 2, 29 of the 32 subjects completed both challenges; no allergic reaction was seen in any of the 32 subjects. Conclusions The new AAF with DHA and ARA at levels similar to those in human milk worldwide is hypoallergenic. It also is safe and supports growth in healthy, term infants. |
| doi_str_mv | 10.1016/j.jpeds.2008.02.043 |
| format | Article |
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In study 2, to evaluate the hypoallergenicity of this new AAF in infants and children with confirmed cow's milk allergy (CMA). Study design In study 1, a total of 165 healthy, full-term, formula-fed infants randomly received the new AAF or control formula. Anthropometric measurements, tolerance, and adverse events were recorded throughout the study. Plasma amino acid profiles were evaluated in a subset of the infants. In study 2, the hypoallergenicity of the new AAF was evaluated in 32 infants and children using a double-blind, placebo-controlled food challenge; an open challenge; and a 7-day feeding. Results In study 1, overall growth, tolerance, and safety outcomes were similar in both groups. In study 2, 29 of the 32 subjects completed both challenges; no allergic reaction was seen in any of the 32 subjects. Conclusions The new AAF with DHA and ARA at levels similar to those in human milk worldwide is hypoallergenic. It also is safe and supports growth in healthy, term infants.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2008.02.043</identifier><identifier>PMID: 18534230</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Amino Acids - administration & dosage ; Animals ; Arachidonic Acid - administration & dosage ; Biological and medical sciences ; Child ; Child, Preschool ; Dietary Supplements ; Docosahexaenoic Acids - administration & dosage ; Double-Blind Method ; Female ; General aspects ; Growth - drug effects ; Humans ; Infant ; Infant Food - adverse effects ; Infant Formula - administration & dosage ; Infant, Newborn ; Male ; Medical sciences ; Milk - adverse effects ; Milk Hypersensitivity - diet therapy ; Milk Hypersensitivity - etiology ; Pediatrics ; Prospective Studies ; Treatment Outcome</subject><ispartof>The Journal of pediatrics, 2008-08, Vol.153 (2), p.266-271</ispartof><rights>Mosby, Inc.</rights><rights>2008 Mosby, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-e01b2bfaa496124d902429d9e466a2e19eb9933583d088cad03f8cf317db13503</citedby><cites>FETCH-LOGICAL-c442t-e01b2bfaa496124d902429d9e466a2e19eb9933583d088cad03f8cf317db13503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpeds.2008.02.043$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20551541$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18534230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burks, Wesley, MD</creatorcontrib><creatorcontrib>Jones, Stacie M., MD</creatorcontrib><creatorcontrib>Berseth, Carol Lynn, MD</creatorcontrib><creatorcontrib>Harris, Cheryl, MS</creatorcontrib><creatorcontrib>Sampson, Hugh A., MD</creatorcontrib><creatorcontrib>Scalabrin, Deolinda M.F., MD, PhD</creatorcontrib><title>Hypoallergenicity and Effects on Growth and Tolerance of a New Amino Acid-Based Formula with Docosahexaenoic Acid and Arachidonic Acid</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Objective In study 1, to compare the effect on growth in healthy infants of a new amino acid–based formula (AAF) and a control extensively hydrolyzed formula (EHF), with both docosahexaenoic acid (DHA) and arachidonic acid (ARA) at levels similar to those in human milk worldwide. In study 2, to evaluate the hypoallergenicity of this new AAF in infants and children with confirmed cow's milk allergy (CMA). Study design In study 1, a total of 165 healthy, full-term, formula-fed infants randomly received the new AAF or control formula. Anthropometric measurements, tolerance, and adverse events were recorded throughout the study. Plasma amino acid profiles were evaluated in a subset of the infants. In study 2, the hypoallergenicity of the new AAF was evaluated in 32 infants and children using a double-blind, placebo-controlled food challenge; an open challenge; and a 7-day feeding. Results In study 1, overall growth, tolerance, and safety outcomes were similar in both groups. In study 2, 29 of the 32 subjects completed both challenges; no allergic reaction was seen in any of the 32 subjects. Conclusions The new AAF with DHA and ARA at levels similar to those in human milk worldwide is hypoallergenic. It also is safe and supports growth in healthy, term infants.</description><subject>Amino Acids - administration & dosage</subject><subject>Animals</subject><subject>Arachidonic Acid - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dietary Supplements</subject><subject>Docosahexaenoic Acids - administration & dosage</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>General aspects</subject><subject>Growth - drug effects</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant Food - adverse effects</subject><subject>Infant Formula - administration & dosage</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Milk - adverse effects</subject><subject>Milk Hypersensitivity - diet therapy</subject><subject>Milk Hypersensitivity - etiology</subject><subject>Pediatrics</subject><subject>Prospective Studies</subject><subject>Treatment Outcome</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksuO0zAUhiMEYjoDT4CEvIFdwvElabwAqQxzQRrBgmFtOfYJdUjjYjeUvsA8N04bgcSGlaWj7_9lfedk2QsKBQVavemKbos2FgygLoAVIPijbEFBLvOq5vxxtgBgLOdiWZ1l5zF2ACAFwNPsjNYlF4zDInu4PWy97nsM33Bwxu0ORA-WXLUtml0kfiA3we936-P03idODwaJb4kmn3BPVhs3eLIyzubvdURLrn3YjL0me5dCH7zxUa_xl8bBO3Pkjk2roM3aWT_Mw2fZk1b3EZ_P70X29frq_vI2v_t88_FydZcbIdguR6ANa1qthawoE1YCE0xaiaKqNEMqsZGS87LmFuraaAu8rU3L6dI2lJfAL7LXp95t8D9GjDu1cdFg3-sB_RhVldJSwgTyE2iCjzFgq7bBbXQ4KApq0q86ddSvJv0KmEr6U-rlXD82G7R_M7PvBLyaAR2N7tvJpot_OAZlSUtBE_f2xGGS8dNhUNE4TOatC2kxynr3n4-8-ydvepdk6_47HjB2fgxD8qyoiimgvkyXMh0K1AB0WXL-G_SzuNw</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Burks, Wesley, MD</creator><creator>Jones, Stacie M., MD</creator><creator>Berseth, Carol Lynn, MD</creator><creator>Harris, Cheryl, MS</creator><creator>Sampson, Hugh A., MD</creator><creator>Scalabrin, Deolinda M.F., MD, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080801</creationdate><title>Hypoallergenicity and Effects on Growth and Tolerance of a New Amino Acid-Based Formula with Docosahexaenoic Acid and Arachidonic Acid</title><author>Burks, Wesley, MD ; Jones, Stacie M., MD ; Berseth, Carol Lynn, MD ; Harris, Cheryl, MS ; Sampson, Hugh A., MD ; Scalabrin, Deolinda M.F., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-e01b2bfaa496124d902429d9e466a2e19eb9933583d088cad03f8cf317db13503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Amino Acids - administration & dosage</topic><topic>Animals</topic><topic>Arachidonic Acid - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dietary Supplements</topic><topic>Docosahexaenoic Acids - administration & dosage</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>General aspects</topic><topic>Growth - drug effects</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant Food - adverse effects</topic><topic>Infant Formula - administration & dosage</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Milk - adverse effects</topic><topic>Milk Hypersensitivity - diet therapy</topic><topic>Milk Hypersensitivity - etiology</topic><topic>Pediatrics</topic><topic>Prospective Studies</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burks, Wesley, MD</creatorcontrib><creatorcontrib>Jones, Stacie M., MD</creatorcontrib><creatorcontrib>Berseth, Carol Lynn, MD</creatorcontrib><creatorcontrib>Harris, Cheryl, MS</creatorcontrib><creatorcontrib>Sampson, Hugh A., MD</creatorcontrib><creatorcontrib>Scalabrin, Deolinda M.F., MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burks, Wesley, MD</au><au>Jones, Stacie M., MD</au><au>Berseth, Carol Lynn, MD</au><au>Harris, Cheryl, MS</au><au>Sampson, Hugh A., MD</au><au>Scalabrin, Deolinda M.F., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoallergenicity and Effects on Growth and Tolerance of a New Amino Acid-Based Formula with Docosahexaenoic Acid and Arachidonic Acid</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>153</volume><issue>2</issue><spage>266</spage><epage>271</epage><pages>266-271</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>Objective In study 1, to compare the effect on growth in healthy infants of a new amino acid–based formula (AAF) and a control extensively hydrolyzed formula (EHF), with both docosahexaenoic acid (DHA) and arachidonic acid (ARA) at levels similar to those in human milk worldwide. In study 2, to evaluate the hypoallergenicity of this new AAF in infants and children with confirmed cow's milk allergy (CMA). Study design In study 1, a total of 165 healthy, full-term, formula-fed infants randomly received the new AAF or control formula. Anthropometric measurements, tolerance, and adverse events were recorded throughout the study. Plasma amino acid profiles were evaluated in a subset of the infants. In study 2, the hypoallergenicity of the new AAF was evaluated in 32 infants and children using a double-blind, placebo-controlled food challenge; an open challenge; and a 7-day feeding. Results In study 1, overall growth, tolerance, and safety outcomes were similar in both groups. In study 2, 29 of the 32 subjects completed both challenges; no allergic reaction was seen in any of the 32 subjects. Conclusions The new AAF with DHA and ARA at levels similar to those in human milk worldwide is hypoallergenic. It also is safe and supports growth in healthy, term infants.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>18534230</pmid><doi>10.1016/j.jpeds.2008.02.043</doi><tpages>6</tpages></addata></record> |
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| subjects | Amino Acids - administration & dosage Animals Arachidonic Acid - administration & dosage Biological and medical sciences Child Child, Preschool Dietary Supplements Docosahexaenoic Acids - administration & dosage Double-Blind Method Female General aspects Growth - drug effects Humans Infant Infant Food - adverse effects Infant Formula - administration & dosage Infant, Newborn Male Medical sciences Milk - adverse effects Milk Hypersensitivity - diet therapy Milk Hypersensitivity - etiology Pediatrics Prospective Studies Treatment Outcome |
| title | Hypoallergenicity and Effects on Growth and Tolerance of a New Amino Acid-Based Formula with Docosahexaenoic Acid and Arachidonic Acid |
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