Airway Epithelial Cell Senescence in the Lung Allograft
Chronic lung allograft dysfunction, manifesting as bronchiolitis obliterans syndrome (BOS), is characterized by airway epithelial injury, impaired epithelial regeneration and subsequent airway remodeling. Increased cellular senescence has been reported in renal and liver allografts affected by chron...
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| Veröffentlicht in: | American journal of transplantation 2008-07, Vol.8 (7), p.1544-1549 |
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| creator | Parker, S. M. Goriwiec, M. R. Borthwick, L. A. Johnson, G. Ward, C. Lordan, J. L. Corris, P. A. Saretzki, G. C. Fisher, A. J. |
| description | Chronic lung allograft dysfunction, manifesting as bronchiolitis obliterans syndrome (BOS), is characterized by airway epithelial injury, impaired epithelial regeneration and subsequent airway remodeling. Increased cellular senescence has been reported in renal and liver allografts affected by chronic allograft dysfunction but the significance of cellular senescence in the airway epithelium of the transplanted lung is unknown. Thirty‐four lung transplant recipients, 20 with stable graft function and 14 with BOS, underwent transbronchial lung biopsy and histochemical studies for senescence markers in small airways. Compared to nontransplant control lung tissue (n = 9), lung allografts demonstrate significantly increased airway epithelial staining for senescence‐associated beta galactosidase (SA β‐gal) (p = 0.0215), p16ink4a (p = 0.0002) and p21waf1/cip (p = 0.0138) but there was no difference in expression of these markers between stable and BOS affected recipients (p > 0.05). This preliminary cross‐sectional study demonstrates that cellular senescence occurs with increased frequency in the airway epithelium of the lung allograft but does not establish any association between airway epithelial senescence and BOS. A prospective longitudinal study is required to better address any potential causal association between airway epithelial senescence in stable allograft recipients and the subsequent development of BOS.
Cellular senescence occurs with increased frequency in the airway epithelium of lung transplants but is not associated with BOS. |
| doi_str_mv | 10.1111/j.1600-6143.2008.02284.x |
| format | Article |
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Cellular senescence occurs with increased frequency in the airway epithelium of lung transplants but is not associated with BOS.</description><identifier>ISSN: 1600-6135</identifier><identifier>EISSN: 1600-6143</identifier><identifier>DOI: 10.1111/j.1600-6143.2008.02284.x</identifier><identifier>PMID: 18557742</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; beta-Galactosidase - metabolism ; Biological and medical sciences ; Biomarkers ; Biopsy, Needle ; Bronchiolitis Obliterans - pathology ; Bronchiolitis Obliterans - physiopathology ; Cellular Senescence ; Cross-Sectional Studies ; Female ; Humans ; Lung - pathology ; Lung - physiology ; Lung Transplantation ; Male ; Medical sciences ; Middle Aged ; Respiratory Mucosa - pathology ; Respiratory Mucosa - physiology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><ispartof>American journal of transplantation, 2008-07, Vol.8 (7), p.1544-1549</ispartof><rights>2008 The Authors Journal compilation © 2008 The American Society of Transplantation and the American Society of Transplant Surgeons</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4474-32af38639f73277c9fadc788467f69e1319e33090d1fd96582ceffe7ba1b3ea93</citedby><cites>FETCH-LOGICAL-c4474-32af38639f73277c9fadc788467f69e1319e33090d1fd96582ceffe7ba1b3ea93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-6143.2008.02284.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-6143.2008.02284.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20567370$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18557742$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parker, S. M.</creatorcontrib><creatorcontrib>Goriwiec, M. R.</creatorcontrib><creatorcontrib>Borthwick, L. A.</creatorcontrib><creatorcontrib>Johnson, G.</creatorcontrib><creatorcontrib>Ward, C.</creatorcontrib><creatorcontrib>Lordan, J. L.</creatorcontrib><creatorcontrib>Corris, P. A.</creatorcontrib><creatorcontrib>Saretzki, G. C.</creatorcontrib><creatorcontrib>Fisher, A. J.</creatorcontrib><title>Airway Epithelial Cell Senescence in the Lung Allograft</title><title>American journal of transplantation</title><addtitle>Am J Transplant</addtitle><description>Chronic lung allograft dysfunction, manifesting as bronchiolitis obliterans syndrome (BOS), is characterized by airway epithelial injury, impaired epithelial regeneration and subsequent airway remodeling. Increased cellular senescence has been reported in renal and liver allografts affected by chronic allograft dysfunction but the significance of cellular senescence in the airway epithelium of the transplanted lung is unknown. Thirty‐four lung transplant recipients, 20 with stable graft function and 14 with BOS, underwent transbronchial lung biopsy and histochemical studies for senescence markers in small airways. Compared to nontransplant control lung tissue (n = 9), lung allografts demonstrate significantly increased airway epithelial staining for senescence‐associated beta galactosidase (SA β‐gal) (p = 0.0215), p16ink4a (p = 0.0002) and p21waf1/cip (p = 0.0138) but there was no difference in expression of these markers between stable and BOS affected recipients (p > 0.05). This preliminary cross‐sectional study demonstrates that cellular senescence occurs with increased frequency in the airway epithelium of the lung allograft but does not establish any association between airway epithelial senescence and BOS. A prospective longitudinal study is required to better address any potential causal association between airway epithelial senescence in stable allograft recipients and the subsequent development of BOS.
Cellular senescence occurs with increased frequency in the airway epithelium of lung transplants but is not associated with BOS.</description><subject>Adolescent</subject><subject>Adult</subject><subject>beta-Galactosidase - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biopsy, Needle</subject><subject>Bronchiolitis Obliterans - pathology</subject><subject>Bronchiolitis Obliterans - physiopathology</subject><subject>Cellular Senescence</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Lung - pathology</subject><subject>Lung - physiology</subject><subject>Lung Transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Respiratory Mucosa - pathology</subject><subject>Respiratory Mucosa - physiology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><issn>1600-6135</issn><issn>1600-6143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkDtPwzAQgC0EoqXwF1AW2BL8SGJ7YKiq8lIlBspsuc65pHKTYjdq--9JaFRWbrmT7ruHPoQighPSxsMqITnGcU5SllCMRYIpFWmyP0PDU-P8VLNsgK5CWGFMOBX0Eg2IyDLOUzpEfFz6nT5E0025_QJXahdNwLnoAyoIBioDUVlFbSuaNdUyGjtXL72222t0YbULcNPnEfp8ms4nL_Hs_fl1Mp7FJk15GjOqLRM5k5YzyrmRVheGC5Hm3OYSCCMSGMMSF8QWMs8ENWAt8IUmCwZashG6P-7d-Pq7gbBV67L9yzldQd0ElUvGhJQdKI6g8XUIHqza-HKt_UERrDppaqU6H6pzozpp6lea2rejt_2NZrGG4m-wt9QCdz2gg9HOel2ZMpw4irOcM45b7vHI7UoHh38_oMZv865iP9r9hgU</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Parker, S. M.</creator><creator>Goriwiec, M. R.</creator><creator>Borthwick, L. A.</creator><creator>Johnson, G.</creator><creator>Ward, C.</creator><creator>Lordan, J. L.</creator><creator>Corris, P. A.</creator><creator>Saretzki, G. C.</creator><creator>Fisher, A. J.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200807</creationdate><title>Airway Epithelial Cell Senescence in the Lung Allograft</title><author>Parker, S. M. ; Goriwiec, M. R. ; Borthwick, L. A. ; Johnson, G. ; Ward, C. ; Lordan, J. L. ; Corris, P. A. ; Saretzki, G. C. ; Fisher, A. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4474-32af38639f73277c9fadc788467f69e1319e33090d1fd96582ceffe7ba1b3ea93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>beta-Galactosidase - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Biopsy, Needle</topic><topic>Bronchiolitis Obliterans - pathology</topic><topic>Bronchiolitis Obliterans - physiopathology</topic><topic>Cellular Senescence</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Lung - pathology</topic><topic>Lung - physiology</topic><topic>Lung Transplantation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Respiratory Mucosa - pathology</topic><topic>Respiratory Mucosa - physiology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parker, S. M.</creatorcontrib><creatorcontrib>Goriwiec, M. R.</creatorcontrib><creatorcontrib>Borthwick, L. A.</creatorcontrib><creatorcontrib>Johnson, G.</creatorcontrib><creatorcontrib>Ward, C.</creatorcontrib><creatorcontrib>Lordan, J. L.</creatorcontrib><creatorcontrib>Corris, P. A.</creatorcontrib><creatorcontrib>Saretzki, G. C.</creatorcontrib><creatorcontrib>Fisher, A. J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parker, S. M.</au><au>Goriwiec, M. R.</au><au>Borthwick, L. A.</au><au>Johnson, G.</au><au>Ward, C.</au><au>Lordan, J. L.</au><au>Corris, P. A.</au><au>Saretzki, G. C.</au><au>Fisher, A. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Airway Epithelial Cell Senescence in the Lung Allograft</atitle><jtitle>American journal of transplantation</jtitle><addtitle>Am J Transplant</addtitle><date>2008-07</date><risdate>2008</risdate><volume>8</volume><issue>7</issue><spage>1544</spage><epage>1549</epage><pages>1544-1549</pages><issn>1600-6135</issn><eissn>1600-6143</eissn><abstract>Chronic lung allograft dysfunction, manifesting as bronchiolitis obliterans syndrome (BOS), is characterized by airway epithelial injury, impaired epithelial regeneration and subsequent airway remodeling. Increased cellular senescence has been reported in renal and liver allografts affected by chronic allograft dysfunction but the significance of cellular senescence in the airway epithelium of the transplanted lung is unknown. Thirty‐four lung transplant recipients, 20 with stable graft function and 14 with BOS, underwent transbronchial lung biopsy and histochemical studies for senescence markers in small airways. Compared to nontransplant control lung tissue (n = 9), lung allografts demonstrate significantly increased airway epithelial staining for senescence‐associated beta galactosidase (SA β‐gal) (p = 0.0215), p16ink4a (p = 0.0002) and p21waf1/cip (p = 0.0138) but there was no difference in expression of these markers between stable and BOS affected recipients (p > 0.05). This preliminary cross‐sectional study demonstrates that cellular senescence occurs with increased frequency in the airway epithelium of the lung allograft but does not establish any association between airway epithelial senescence and BOS. A prospective longitudinal study is required to better address any potential causal association between airway epithelial senescence in stable allograft recipients and the subsequent development of BOS.
Cellular senescence occurs with increased frequency in the airway epithelium of lung transplants but is not associated with BOS.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18557742</pmid><doi>10.1111/j.1600-6143.2008.02284.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult beta-Galactosidase - metabolism Biological and medical sciences Biomarkers Biopsy, Needle Bronchiolitis Obliterans - pathology Bronchiolitis Obliterans - physiopathology Cellular Senescence Cross-Sectional Studies Female Humans Lung - pathology Lung - physiology Lung Transplantation Male Medical sciences Middle Aged Respiratory Mucosa - pathology Respiratory Mucosa - physiology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases |
| title | Airway Epithelial Cell Senescence in the Lung Allograft |
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