Cancer as an overhealing wound: an old hypothesis revisited

Key Points A series of clinical and preclinical findings suggest a relationship between wound repair and cancer: malignant tumours often develop at sites of chronic injury and permanent tissue damage through chronic inflammation is a major risk factor for the development of cancer. Recent studies ha...

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Veröffentlicht in:	Nature reviews. Molecular cell biology 2008-08, Vol.9 (8), p.628-638
Hauptverfasser:	Schäfer, Matthias, Werner, Sabine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomedical and Life Sciences Cancer Cancer Research Cell Biology Cicatrix - pathology Developmental Biology Epithelium - physiology Extracellular Matrix - metabolism Extracellular Matrix - physiology Fibrin - metabolism Fibroblasts Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genes Genetic aspects Genetically modified mice Growth factors Health aspects Humans Hypotheses Inflammation Inflammation - pathology Life Sciences Models, Biological Neoplasms - etiology Neoplasms - genetics Neovascularization, Physiologic - physiology review-article Risk factors Sarcoma Skin Stem Cells Tumors Ulcers Wound healing Wound Healing - genetics Wound Healing - physiology
Online-Zugang:	Volltext
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