Regulation of TNFR1 and CD95 signalling by receptor compartmentalization

Tumour-necrosis factor receptor-1 (TNFR1) and CD95 can transduce pro-apoptotic and anti-apoptotic signals, but what determines the specificity of signalling events? It is possible that the endosomal compartment functions as a signalling organelle that selectively transmits death signals from TNFR1 a...

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Veröffentlicht in:	Nature reviews. Molecular cell biology 2008-08, Vol.9 (8), p.655-662
Hauptverfasser:	Schütze, Stefan, Tchikov, Vladimir, Schneider-Brachert, Wulf
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - physiology Biochemistry Biomedical and Life Sciences Cancer Research Cell Biology Cell Compartmentation - physiology Cell death Cell receptors Cellular signal transduction Developmental Biology Endocytosis fas Receptor - metabolism fas Receptor - physiology Growth factors Humans Kinases Life Sciences Ligands Models, Biological Mortality opinion-2 Physiological aspects Protein Transport - physiology Proteins Receptors, Tumor Necrosis Factor, Type I - metabolism Receptors, Tumor Necrosis Factor, Type I - physiology Signal transduction Signal Transduction - physiology Stem Cells Transcription factors
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