Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes

To elucidate the physiological role of sterol regulatory element-binding protein-1 (SREBP-1), the hepatic mRNA levels of genes encoding various lipogenic enzymes were estimated in SREBP-1 gene knockout mice after a fasting-refeeding treatment, which is an established dietary manipulation for the ind...

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Veröffentlicht in:	The Journal of biological chemistry 1999-12, Vol.274 (50), p.35832-35839
Hauptverfasser:	Shimano, H, Yahagi, N, Amemiya-Kudo, M, Hasty, A.H, Osuga, J, Tamura, Y, Shionoiri, F, Iizuka, Y, Ohashi, K, Harada, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl-CoA Carboxylase - biosynthesis Acetyl-CoA Carboxylase - genetics adipose tissue Animal Nutritional Physiological Phenomena Animals ATP citrate carbohydrates CCAAT-Enhancer-Binding Proteins cholesterol Cholesterol - blood Cholesterol - metabolism cholesterol biosynthetic genes Diet DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Eating Enzyme Induction enzymes Fasting Fatty Acid Synthases - biosynthesis Fatty Acid Synthases - genetics fatty acid synthetic genes fatty acids Fatty Acids, Nonesterified - blood Female gene expression Gene Expression Regulation Gene Expression Regulation, Enzymologic glucose-6-phosphate dehydrogenase Glycerol-3-phosphate acyltransferase high carbohydrate diet Hydroxymethylglutaryl CoA Reductases - biosynthesis Hydroxymethylglutaryl CoA Reductases - genetics Hydroxymethylglutaryl-CoA Synthase - genetics lipogenesis liver Liver - metabolism luciferase messenger RNA Mice Mice, Knockout mutants Nuclear Proteins - deficiency Nuclear Proteins - genetics Nuclear Proteins - metabolism repletion reporter genes RNA, Messenger - genetics SREBP-1 protein starvation Stearoyl-CoA Desaturase - biosynthesis Stearoyl-CoA Desaturase - genetics Sterol Regulatory Element Binding Protein 1 Sterol Regulatory Element Binding Protein 2 transcription (genetics) transcription factors Transcription Factors - genetics Transcription Factors - metabolism Triglycerides - blood Triglycerides - metabolism
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