Induction of Th2 Responses and IgE Is Largely Due to Carbohydrates Functioning as Adjuvants on Schistosoma mansoni Egg Antigens

Infection with the helminth parasite Schistosoma mansoni induces a pronounced Th2-type response that is associated with significant IgE production. To better understand how the parasite drives these responses, we investigated the relative roles of proteins and carbohydrates in driving Th2-type and/o...

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Veröffentlicht in:	The Journal of immunology (1950) 1999-12, Vol.163 (12), p.6712-6717
Hauptverfasser:	Okano, Mitsuhiro, Satoskar, Abhay R, Nishizaki, Kazunori, Abe, Mie, Harn, Donald A., Jr
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - metabolism Adjuvants, Immunologic - physiology Administration, Intranasal AIDS/HIV Animals Antibodies, Helminth - biosynthesis Antigens, Helminth - administration & dosage Antigens, Helminth - immunology Antigens, Helminth - metabolism Carbohydrate Metabolism Carbohydrates - administration & dosage Carbohydrates - immunology Cells, Cultured Cytokines - antagonists & inhibitors Cytokines - biosynthesis Eosinophilia - immunology Eosinophilia - pathology Epitopes, T-Lymphocyte - immunology Epitopes, T-Lymphocyte - metabolism Female Immunoglobulin E - biosynthesis Mice Mice, Inbred BALB C Nasal Mucosa - immunology Nasal Mucosa - pathology Ovum - immunology Periodic Acid - pharmacology Schistosoma mansoni Schistosoma mansoni - immunology Th2 Cells - immunology Th2 Cells - metabolism
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