Inhibition of endothelial cell migration, intercellular communication, and vascular tube formation by thromboxane A(2)

The eicosanoid thromboxane A(2) (TXA(2)) is released by activated platelets, monocytes, and the vessel wall and interacts with high affinity receptors expressed in several tissues including endothelium. Whether TXA(2) might alter endothelial migration and tube formation, two determinants of angiogen...

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Veröffentlicht in:	The Journal of biological chemistry 1999-12, Vol.274 (50), p.35562-35570
Hauptverfasser:	Ashton, A W, Yokota, R, John, G, Zhao, S, Suadicani, S O, Spray, D C, Ware, J A
Format:	Artikel
Sprache:	eng
Schlagworte:	Bridged Bicyclo Compounds, Heterocyclic - pharmacology Calcium - metabolism Capillaries - drug effects Capillaries - physiology Cell Communication - drug effects Cells, Cultured Chemotaxis - drug effects Connexin 43 - metabolism Cytoskeleton - drug effects Cytoskeleton - ultrastructure Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Fatty Acids, Unsaturated - pharmacology Gap Junctions - drug effects Gap Junctions - physiology Humans Integrins - analysis Neovascularization, Physiologic - drug effects Thromboxane A2 - pharmacology Umbilical Veins Wound Healing - drug effects
Online-Zugang:	Volltext
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