Effects of indomethacin and ibuprofen on mesenteric and renal blood flow in preterm infants with patent ductus arteriosus
Objective: To evaluate the effect of intravenous ibuprofen and indomethacin for treatment of patent ductus arteriosus (PDA) on mesenteric and renal blood flow velocity in preterm infants. Study design: Seventeen mechanically ventilated preterm infants (
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| Veröffentlicht in: | The Journal of pediatrics 1999-12, Vol.135 (6), p.733-738 |
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| container_title | The Journal of pediatrics |
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| creator | Pezzati, Marco Vangi, Venturella Biagiotti, Roberto Bertini, Giovanna Cianciulli, Domenico Rubaltelli, Firmino F. |
| description | Objective: To evaluate the effect of intravenous ibuprofen and indomethacin for treatment of patent ductus arteriosus (PDA) on mesenteric and renal blood flow velocity in preterm infants.
Study design: Seventeen mechanically ventilated preterm infants ( |
| doi_str_mv | 10.1016/S0022-3476(99)70093-4 |
| format | Article |
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Study design: Seventeen mechanically ventilated preterm infants (<33 weeks’ gestation) with PDA received either 0.2 mg/kg indomethacin (n = 8) or 10 mg/kg ibuprofen (n = 9), infused over 15 minutes. Mesenteric and renal blood flow velocity were measured by using Doppler ultrasonography.
Results: Indomethacin caused a significant reduction in mesenteric and renal blood flow velocity 30 minutes after drug administration; mesenteric and renal blood flow velocity did not return to the pretreatment values by 120 minutes. Ibuprofen did not alter blood flow 30 minutes after treatment, and blood flow increased 120 minutes after treatment. Mesenteric and renal blood flow velocity changes were significantly different between the 2 treatment groups.
Conclusions: Compared with indomethacin, ibuprofen did not significantly reduce mesenteric and renal blood flow velocity.(J Pediatr 1999;135:733-8)</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(99)70093-4</identifier><identifier>PMID: 10586177</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Biological and medical sciences ; Delivery. Postpartum. Lactation ; Disorders ; Ductus Arteriosus, Patent - physiopathology ; Gynecology. Andrology. Obstetrics ; Humans ; Ibuprofen - therapeutic use ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases - physiopathology ; Kidney - blood supply ; Medical sciences ; Mesentery - blood supply ; Regional Blood Flow - drug effects</subject><ispartof>The Journal of pediatrics, 1999-12, Vol.135 (6), p.733-738</ispartof><rights>1999 Mosby, Inc.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-9a1e459a6be79e83e0c31be1eb3e04d420f85c8e7b804d59824b73cd46e3487a3</citedby><cites>FETCH-LOGICAL-c442t-9a1e459a6be79e83e0c31be1eb3e04d420f85c8e7b804d59824b73cd46e3487a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-3476(99)70093-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1263987$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10586177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pezzati, Marco</creatorcontrib><creatorcontrib>Vangi, Venturella</creatorcontrib><creatorcontrib>Biagiotti, Roberto</creatorcontrib><creatorcontrib>Bertini, Giovanna</creatorcontrib><creatorcontrib>Cianciulli, Domenico</creatorcontrib><creatorcontrib>Rubaltelli, Firmino F.</creatorcontrib><title>Effects of indomethacin and ibuprofen on mesenteric and renal blood flow in preterm infants with patent ductus arteriosus</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Objective: To evaluate the effect of intravenous ibuprofen and indomethacin for treatment of patent ductus arteriosus (PDA) on mesenteric and renal blood flow velocity in preterm infants.
Study design: Seventeen mechanically ventilated preterm infants (<33 weeks’ gestation) with PDA received either 0.2 mg/kg indomethacin (n = 8) or 10 mg/kg ibuprofen (n = 9), infused over 15 minutes. Mesenteric and renal blood flow velocity were measured by using Doppler ultrasonography.
Results: Indomethacin caused a significant reduction in mesenteric and renal blood flow velocity 30 minutes after drug administration; mesenteric and renal blood flow velocity did not return to the pretreatment values by 120 minutes. Ibuprofen did not alter blood flow 30 minutes after treatment, and blood flow increased 120 minutes after treatment. Mesenteric and renal blood flow velocity changes were significantly different between the 2 treatment groups.
Conclusions: Compared with indomethacin, ibuprofen did not significantly reduce mesenteric and renal blood flow velocity.(J Pediatr 1999;135:733-8)</description><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Disorders</subject><subject>Ductus Arteriosus, Patent - physiopathology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Ibuprofen - therapeutic use</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Premature, Diseases - physiopathology</subject><subject>Kidney - blood supply</subject><subject>Medical sciences</subject><subject>Mesentery - blood supply</subject><subject>Regional Blood Flow - drug effects</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vFSEUhomxsbfVn6BhYYwupsLA8LFqTNOqSZMuqmvCwCHFzMAVZmz67-V-RN254hCe9xx4QOg1JReUUPHxnpC-7xiX4r3WHyQhmnX8GdpQomUnFGPP0eYPcorOav1BGsQJeYFOKRmUoFJu0NN1COCWinPAMfk8w_JgXUzYJo_juG5LDpBwTniGCmmBEt3-rECyEx6nnD0OU35sabwt0IC5lcGm1vMxLg94a5eWw351y1qxLbsWua71JToJdqrw6rieo-8319-uvnS3d5-_Xn267Rzn_dJpS4EP2ooRpAbFgDhGR6AwtpJ73pOgBqdAjqptB616PkrmPBfAuJKWnaN3h77tKT9XqIuZY3UwTTZBXqsRmrFBMNnA4QC6kmstEMy2xNmWJ0OJ2Tk3e-dmJ9RobfbODW-5N8cB6ziD_yd1kNyAt0fAVmenUGxysf7lesG02mGXBwyajV8RiqkuQnLgY2lfZHyO_7nJb0zVn_I</recordid><startdate>19991201</startdate><enddate>19991201</enddate><creator>Pezzati, Marco</creator><creator>Vangi, Venturella</creator><creator>Biagiotti, Roberto</creator><creator>Bertini, Giovanna</creator><creator>Cianciulli, Domenico</creator><creator>Rubaltelli, Firmino F.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991201</creationdate><title>Effects of indomethacin and ibuprofen on mesenteric and renal blood flow in preterm infants with patent ductus arteriosus</title><author>Pezzati, Marco ; Vangi, Venturella ; Biagiotti, Roberto ; Bertini, Giovanna ; Cianciulli, Domenico ; Rubaltelli, Firmino F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-9a1e459a6be79e83e0c31be1eb3e04d420f85c8e7b804d59824b73cd46e3487a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Delivery. Postpartum. Lactation</topic><topic>Disorders</topic><topic>Ductus Arteriosus, Patent - physiopathology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Ibuprofen - therapeutic use</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Premature, Diseases - physiopathology</topic><topic>Kidney - blood supply</topic><topic>Medical sciences</topic><topic>Mesentery - blood supply</topic><topic>Regional Blood Flow - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pezzati, Marco</creatorcontrib><creatorcontrib>Vangi, Venturella</creatorcontrib><creatorcontrib>Biagiotti, Roberto</creatorcontrib><creatorcontrib>Bertini, Giovanna</creatorcontrib><creatorcontrib>Cianciulli, Domenico</creatorcontrib><creatorcontrib>Rubaltelli, Firmino F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pezzati, Marco</au><au>Vangi, Venturella</au><au>Biagiotti, Roberto</au><au>Bertini, Giovanna</au><au>Cianciulli, Domenico</au><au>Rubaltelli, Firmino F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of indomethacin and ibuprofen on mesenteric and renal blood flow in preterm infants with patent ductus arteriosus</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1999-12-01</date><risdate>1999</risdate><volume>135</volume><issue>6</issue><spage>733</spage><epage>738</epage><pages>733-738</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>Objective: To evaluate the effect of intravenous ibuprofen and indomethacin for treatment of patent ductus arteriosus (PDA) on mesenteric and renal blood flow velocity in preterm infants.
Study design: Seventeen mechanically ventilated preterm infants (<33 weeks’ gestation) with PDA received either 0.2 mg/kg indomethacin (n = 8) or 10 mg/kg ibuprofen (n = 9), infused over 15 minutes. Mesenteric and renal blood flow velocity were measured by using Doppler ultrasonography.
Results: Indomethacin caused a significant reduction in mesenteric and renal blood flow velocity 30 minutes after drug administration; mesenteric and renal blood flow velocity did not return to the pretreatment values by 120 minutes. Ibuprofen did not alter blood flow 30 minutes after treatment, and blood flow increased 120 minutes after treatment. Mesenteric and renal blood flow velocity changes were significantly different between the 2 treatment groups.
Conclusions: Compared with indomethacin, ibuprofen did not significantly reduce mesenteric and renal blood flow velocity.(J Pediatr 1999;135:733-8)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>10586177</pmid><doi>10.1016/S0022-3476(99)70093-4</doi><tpages>6</tpages></addata></record> |
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| subjects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biological and medical sciences Delivery. Postpartum. Lactation Disorders Ductus Arteriosus, Patent - physiopathology Gynecology. Andrology. Obstetrics Humans Ibuprofen - therapeutic use Infant, Newborn Infant, Premature Infant, Premature, Diseases - physiopathology Kidney - blood supply Medical sciences Mesentery - blood supply Regional Blood Flow - drug effects |
| title | Effects of indomethacin and ibuprofen on mesenteric and renal blood flow in preterm infants with patent ductus arteriosus |
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