Sensorineural Hearing Loss in Primary Antibody Deficiency Disorders

To evaluate the hearing function in patients affected by primary antibody deficiency disorders. Forty-seven patients, 25 of whom were affected by X-linked agammaglobulinemia and 22 of whom were affected by common variable immunodeficiency were evaluated with audiologic tests that included pure tone...

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Veröffentlicht in:The Journal of pediatrics 2008-08, Vol.153 (2), p.293-296
Hauptverfasser: Berlucchi, Marco, MD, Soresina, Annarosa, MD, Redaelli De Zinis, Luca O., MD, Valetti, Luisa, MD, Valotti, Roberta, MD, Lougaris, Vassilios, MD, Meini, Antonella, MD, Salsi, Daria, MD, Nicolai, Piero, MD, Plebani, Alessandro, MD
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container_end_page 296
container_issue 2
container_start_page 293
container_title The Journal of pediatrics
container_volume 153
creator Berlucchi, Marco, MD
Soresina, Annarosa, MD
Redaelli De Zinis, Luca O., MD
Valetti, Luisa, MD
Valotti, Roberta, MD
Lougaris, Vassilios, MD
Meini, Antonella, MD
Salsi, Daria, MD
Nicolai, Piero, MD
Plebani, Alessandro, MD
description To evaluate the hearing function in patients affected by primary antibody deficiency disorders. Forty-seven patients, 25 of whom were affected by X-linked agammaglobulinemia and 22 of whom were affected by common variable immunodeficiency were evaluated with audiologic tests that included pure tone audiometry, acoustic immittance assessment and auditory brainstem-evoked response. Eighteen patients (38%), 7 with X-linked agammaglobulinemia and 11 with common variable immunodeficiency, showed sensorineural hearing loss, bilateral in 12 and unilateral in 6. Our data underline the high frequency of hearing loss in patients with antibody deficiency and suggest that a systematic audiologic evaluation should be part of the clinical care of these patients.
doi_str_mv 10.1016/j.jpeds.2008.03.008
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subjects Acoustic Impedance Tests
Adolescent
Adult
Agammaglobulinemia - complications
Agammaglobulinemia - immunology
Audiometry, Pure-Tone
B-Lymphocytes
Biological and medical sciences
Child
Child, Preschool
Common Variable Immunodeficiency - complications
Common Variable Immunodeficiency - immunology
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Evoked Potentials, Auditory, Brain Stem
Female
General aspects
Hearing Loss, Sensorineural - diagnosis
Hearing Loss, Sensorineural - immunology
Humans
Immunoglobulin A - blood
Immunoglobulin G - blood
Immunoglobulin M - blood
Lymphocyte Count
Male
Medical sciences
Middle Aged
Non tumoral diseases
Otorhinolaryngology. Stomatology
Pediatrics
X-Linked Combined Immunodeficiency Diseases - complications
X-Linked Combined Immunodeficiency Diseases - immunology
title Sensorineural Hearing Loss in Primary Antibody Deficiency Disorders
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