Family-based association studies of bipolar disorder with candidate genes involved in dopamine neurotransmission: DBH, DAT1, COMT, DRD2, DRD3 and DRD5

The dopaminergic system has been implicated in the aetiology of mood disorders. We conducted family-based association studies for polymorphisms at three genes involved in the metabolism of dopamine: dopamine transporter (DAT1), dopamine-β-hydroxylase (DBH) and catechol-O-methyl transferase (COMT); a...

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Veröffentlicht in:	Molecular psychiatry 1999-11, Vol.4 (6), p.558-565
Hauptverfasser:	Kirov, G, Jones, I, McCandless, F, Craddock, N, Owen, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Behavioral Sciences Biological and medical sciences Biological Psychology Bipolar disorder Bipolar Disorder - genetics Bipolar disorders Brain - enzymology Brain Chemistry - genetics Carrier Proteins - genetics Catechol Catechol O-Methyltransferase - genetics DNA nucleotidylexotransferase DNA Primers Dopamine Dopamine - genetics Dopamine beta-Hydroxylase - genetics Dopamine D2 receptors Dopamine D3 receptors Dopamine D5 receptors Dopamine Plasma Membrane Transport Proteins Dopamine receptors Dopamine transporter Dopamine β-monooxygenase England European Continental Ancestry Group - genetics Family Health Female Genotype Humans Hydroxylase Linkage Disequilibrium Male Medical sciences Medicine Medicine & Public Health Membrane Glycoproteins Membrane Transport Proteins Middle Aged Mood disorders Nerve Tissue Proteins Neurosciences Neurotransmission original-research-article Penetrance Pharmacotherapy Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, Dopamine D1 - genetics Receptors, Dopamine D2 - genetics Receptors, Dopamine D3 Receptors, Dopamine D5 Statistical analysis Synaptic Transmission - genetics Wales
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