TGF-beta promotes thyroid epithelial cell hyperplasia and fibrosis in IFN-gamma-deficient NOD.H-2h4 mice

IFN-gamma(-/-)NOD.H-2h4 mice given 0.05% NaI in their water develop severe thyroid epithelial cell (thyrocyte) hyperplasia and proliferation (TEC H/P) and fibrosis. Proliferating thyrocytes of IFN-gamma(-/-) mice with TEC H/P produce TGF-beta as demonstrated by immunohistochemical staining and in si...

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Veröffentlicht in:	The Journal of immunology (1950) 2008-08, Vol.181 (3), p.2238-2245
Hauptverfasser:	Yu, Shiguang, Sharp, Gordon C, Braley-Mullen, Helen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - immunology Cell Proliferation Epithelial Cells - cytology Epithelial Cells - metabolism Fibrosis - genetics Fibrosis - metabolism Fibrosis - pathology Interferon-gamma - deficiency Interferon-gamma - genetics Interferon-gamma - metabolism Mice Mice, Inbred NOD Mice, Knockout Phosphorylation Protein-Serine-Threonine Kinases - metabolism Receptor, Transforming Growth Factor-beta Type II Receptors, Transforming Growth Factor beta - metabolism Smad2 Protein - metabolism Smad3 Protein - metabolism Spleen - immunology Spleen - metabolism Thymus Hyperplasia - genetics Thymus Hyperplasia - metabolism Thymus Hyperplasia - pathology Transforming Growth Factor beta - genetics Transforming Growth Factor beta - immunology Transforming Growth Factor beta - metabolism
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