Determination of 3-hydroxyisovalerylcarnitine and other acylcarnitine levels using liquid chromatography–tandem mass spectrometry in serum and urine of a patient with multiple carboxylase deficiency
Due to its increased concentration in blood, 3-hydroxyisovalerylcarnitine (C5OH-I) is an important indicator for the diagnosis of organic acidemias in newborns. However, C5OH-I has not been used as a standard in tandem mass spectrometric (MS/MS) assays because its isolation is difficult. We develope...
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Veröffentlicht in: | Journal of chromatography. B 2008-07, Vol.870 (2), p.154-159 |
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Sprache: | eng |
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