Mechanical Resistance of Peripheral Nerve Repair with Biological Glue and with Conventional Suture at Different Postoperative Times
ABSTRACT Regardless of its type, the repair of a peripheral nerve must ideally permit early motion of the affected limb and resist disruption by the tensile forces generated throughout the healing process and regeneration. A comparative study of the mechanical resistance of the repair of the sciatic...
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| Veröffentlicht in: | Journal of reconstructive microsurgery 2008-07, Vol.24 (5), p.327-332 |
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| container_title | Journal of reconstructive microsurgery |
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| creator | Nishimura, Marcelo Tadashi Mazzer, Nilton Barbieri, Cláudio Henrique Moro, Carlos Alberto |
| description | ABSTRACT
Regardless of its type, the repair of a peripheral nerve must ideally permit early motion of the affected limb and resist disruption by the tensile forces generated throughout the healing process and regeneration. A comparative study of the mechanical resistance of the repair of the sciatic nerve with biological glue and conventional microsurgical suture over time was undertaken in 48 rats. Both right and left sciatic nerves were exposed simultaneously and repaired at random with the glue on one side and conventional suture on the opposite side. Mechanical resistance of the repair was evaluated in situ with a universal testing machine using a hooklike accessory applied proximally to the repair site, immediately and at 7, 14, and 28 days postoperatively. A load was applied at the rate of 2 mm/min till rupture. The resistance of both types of repair significantly increased up to day 14 (P |
| doi_str_mv | 10.1055/s-2008-1080535 |
| format | Article |
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Regardless of its type, the repair of a peripheral nerve must ideally permit early motion of the affected limb and resist disruption by the tensile forces generated throughout the healing process and regeneration. A comparative study of the mechanical resistance of the repair of the sciatic nerve with biological glue and conventional microsurgical suture over time was undertaken in 48 rats. Both right and left sciatic nerves were exposed simultaneously and repaired at random with the glue on one side and conventional suture on the opposite side. Mechanical resistance of the repair was evaluated in situ with a universal testing machine using a hooklike accessory applied proximally to the repair site, immediately and at 7, 14, and 28 days postoperatively. A load was applied at the rate of 2 mm/min till rupture. The resistance of both types of repair significantly increased up to day 14 (P < 0.001), and the repair with the glue was significantly less resistant than repair with conventional suture immediately postoperatively (P < 0.001) and on day 7 (P = 0.03). Resistance became equivalent for the two types of repair on days 14 (P = 0.67) and 28 (P = 0.34). The change in resistance of both types of repair with time was in accordance with the power function numeric formula.</description><identifier>ISSN: 0743-684X</identifier><identifier>EISSN: 1098-8947</identifier><identifier>DOI: 10.1055/s-2008-1080535</identifier><identifier>PMID: 18597220</identifier><identifier>CODEN: JRMIE2</identifier><language>eng</language><publisher>New York, NY: Thieme</publisher><subject>Animals ; Biological and medical sciences ; Fibrin Tissue Adhesive - pharmacology ; General aspects ; Male ; Medical sciences ; Rats ; Rats, Wistar ; Sciatic Nerve - surgery ; Statistics, Nonparametric ; Suture Techniques ; Tensile Strength ; Time Factors</subject><ispartof>Journal of reconstructive microsurgery, 2008-07, Vol.24 (5), p.327-332</ispartof><rights>Thieme Medical Publishers</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-205904fdfb2063fb8d3fb83bea2d9bc6414ecc4a2acc44cac4a8c092877075213</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2008-1080535.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2008-1080535$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,776,780,3003,3004,27903,27904,54538,54539</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20543765$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18597220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nishimura, Marcelo Tadashi</creatorcontrib><creatorcontrib>Mazzer, Nilton</creatorcontrib><creatorcontrib>Barbieri, Cláudio Henrique</creatorcontrib><creatorcontrib>Moro, Carlos Alberto</creatorcontrib><title>Mechanical Resistance of Peripheral Nerve Repair with Biological Glue and with Conventional Suture at Different Postoperative Times</title><title>Journal of reconstructive microsurgery</title><addtitle>J reconstr Microsurg</addtitle><description>ABSTRACT
Regardless of its type, the repair of a peripheral nerve must ideally permit early motion of the affected limb and resist disruption by the tensile forces generated throughout the healing process and regeneration. A comparative study of the mechanical resistance of the repair of the sciatic nerve with biological glue and conventional microsurgical suture over time was undertaken in 48 rats. Both right and left sciatic nerves were exposed simultaneously and repaired at random with the glue on one side and conventional suture on the opposite side. Mechanical resistance of the repair was evaluated in situ with a universal testing machine using a hooklike accessory applied proximally to the repair site, immediately and at 7, 14, and 28 days postoperatively. A load was applied at the rate of 2 mm/min till rupture. The resistance of both types of repair significantly increased up to day 14 (P < 0.001), and the repair with the glue was significantly less resistant than repair with conventional suture immediately postoperatively (P < 0.001) and on day 7 (P = 0.03). Resistance became equivalent for the two types of repair on days 14 (P = 0.67) and 28 (P = 0.34). The change in resistance of both types of repair with time was in accordance with the power function numeric formula.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Fibrin Tissue Adhesive - pharmacology</subject><subject>General aspects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sciatic Nerve - surgery</subject><subject>Statistics, Nonparametric</subject><subject>Suture Techniques</subject><subject>Tensile Strength</subject><subject>Time Factors</subject><issn>0743-684X</issn><issn>1098-8947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1v1DAURS0EotPCliXKBnYpzx9JnCUMUJDaUkGR2FmO88y4SuJgO0Vd94_jYSJYdWNbuudd6x1CXlA4pVBVb2LJAGRJQULFq0dkQ6GVpWxF85hsoBG8rKX4cUSOY7wBoKKl7Ck5orJqG8ZgQ-4v0Oz05Iweiq8YXUx6Mlh4W1xhcPMOQw4uMdxijmftQvHbpV3xzvnB__w7dTYsWOipPwRbP93ilJyfcvRtSUvIYSreO2sx5KC48jH5Odcmlzuv3YjxGXli9RDx-XqfkO8fP1xvP5XnX84-b9-el4bXNOVFqxaE7W3HoOa2k_3-4B1q1redqQUVaIzQTOdTGJ2f0kDLZNNAUzHKT8jrQ-8c_K8FY1KjiwaHQU_ol6jqlnPgFWTw9ACa4GMMaNUc3KjDnaKg9tpVVHvtatWeB16uzUs3Yv8fXz1n4NUK6Jil2ZAtu_iPy6sJ3tT7ovLApZ3DEdWNX0I2GR_6-A_0b5qx</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Nishimura, Marcelo Tadashi</creator><creator>Mazzer, Nilton</creator><creator>Barbieri, Cláudio Henrique</creator><creator>Moro, Carlos Alberto</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080701</creationdate><title>Mechanical Resistance of Peripheral Nerve Repair with Biological Glue and with Conventional Suture at Different Postoperative Times</title><author>Nishimura, Marcelo Tadashi ; Mazzer, Nilton ; Barbieri, Cláudio Henrique ; Moro, Carlos Alberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-205904fdfb2063fb8d3fb83bea2d9bc6414ecc4a2acc44cac4a8c092877075213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Fibrin Tissue Adhesive - pharmacology</topic><topic>General aspects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sciatic Nerve - surgery</topic><topic>Statistics, Nonparametric</topic><topic>Suture Techniques</topic><topic>Tensile Strength</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishimura, Marcelo Tadashi</creatorcontrib><creatorcontrib>Mazzer, Nilton</creatorcontrib><creatorcontrib>Barbieri, Cláudio Henrique</creatorcontrib><creatorcontrib>Moro, Carlos Alberto</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of reconstructive microsurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishimura, Marcelo Tadashi</au><au>Mazzer, Nilton</au><au>Barbieri, Cláudio Henrique</au><au>Moro, Carlos Alberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanical Resistance of Peripheral Nerve Repair with Biological Glue and with Conventional Suture at Different Postoperative Times</atitle><jtitle>Journal of reconstructive microsurgery</jtitle><addtitle>J reconstr Microsurg</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>24</volume><issue>5</issue><spage>327</spage><epage>332</epage><pages>327-332</pages><issn>0743-684X</issn><eissn>1098-8947</eissn><coden>JRMIE2</coden><abstract>ABSTRACT
Regardless of its type, the repair of a peripheral nerve must ideally permit early motion of the affected limb and resist disruption by the tensile forces generated throughout the healing process and regeneration. A comparative study of the mechanical resistance of the repair of the sciatic nerve with biological glue and conventional microsurgical suture over time was undertaken in 48 rats. Both right and left sciatic nerves were exposed simultaneously and repaired at random with the glue on one side and conventional suture on the opposite side. Mechanical resistance of the repair was evaluated in situ with a universal testing machine using a hooklike accessory applied proximally to the repair site, immediately and at 7, 14, and 28 days postoperatively. A load was applied at the rate of 2 mm/min till rupture. The resistance of both types of repair significantly increased up to day 14 (P < 0.001), and the repair with the glue was significantly less resistant than repair with conventional suture immediately postoperatively (P < 0.001) and on day 7 (P = 0.03). Resistance became equivalent for the two types of repair on days 14 (P = 0.67) and 28 (P = 0.34). The change in resistance of both types of repair with time was in accordance with the power function numeric formula.</abstract><cop>New York, NY</cop><pub>Thieme</pub><pmid>18597220</pmid><doi>10.1055/s-2008-1080535</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Animals Biological and medical sciences Fibrin Tissue Adhesive - pharmacology General aspects Male Medical sciences Rats Rats, Wistar Sciatic Nerve - surgery Statistics, Nonparametric Suture Techniques Tensile Strength Time Factors |
| title | Mechanical Resistance of Peripheral Nerve Repair with Biological Glue and with Conventional Suture at Different Postoperative Times |
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