Selective inhibition of amino-terminal methionine processing by TNP-470 and ovalicin in endothelial cells

Background: The angiogenesis inhibitors TNP-470 and ovalicin potently suppress endothelial cell growth. Both drugs also specifically inhibit methionine aminopeptidase 2 (MetAP2) in vitro. Inhibition of MetAP2 and changes in initiator methionine removal in drug-treated endothelial cells have not been...

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Veröffentlicht in:	Chemistry & biology 1999-11, Vol.6 (11), p.823-833
Hauptverfasser:	Turk, Benjamin E, Griffith, Eric C, Wolf, Susan, Biemann, Klaus, Chang, Yie-Hwa, Liu, Jun O
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Aminopeptidases - antagonists & inhibitors angiogenesis Angiogenesis Inhibitors - pharmacology Animals Aorta Cattle Cell Division - drug effects Cells, Cultured Cyclohexanes Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Glyceraldehyde-3-Phosphate Dehydrogenases - chemistry Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism Humans Metalloendopeptidases - antagonists & inhibitors Methionine - metabolism methionine aminopeptidase Molecular Sequence Data Myristic Acid - metabolism ovalicin Peptide Fragments - chemistry Protein Processing, Post-Translational - drug effects Recombinant Proteins - chemistry Recombinant Proteins - metabolism Sesquiterpenes - pharmacology TNP-470 Umbilical Veins
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