Creatine corrects muscle 31P spectrum in gyrate atrophy with hyperornithinaemia

Background Eye fundus destruction and type II muscle fiber atrophy in gyrate atrophy of the choroid and retina with hyperornithinaemia (GA) may be mediated by elevated ornithine concentrations which strongly inhibit creatine biosynthesis. This results in deficiency of creatine phosphate (PCr), a key...

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Veröffentlicht in:	European journal of clinical investigation 1999-12, Vol.29 (12), p.1060-1065
Hauptverfasser:	Heinänen, K, Näntö-Salonen, K, Komu, M, Erkintalo, M, Alanen, A, Heinonen, O J, Pulkki, K, Nikoskelainen, E, Sipilä, I, Simell, O
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological and medical sciences Child Creatine - therapeutic use Creatine phosphate Dietary Supplements Female Glycine - analogs & derivatives Glycine - therapeutic use Gyrate Atrophy - complications Gyrate Atrophy - drug therapy Gyrate Atrophy - metabolism gyrate atrophy of the choroid and retina Humans hyperornithinaemia Magnetic Resonance Spectroscopy Male Medical sciences Metabolic diseases Methionine - therapeutic use Middle Aged Miscellaneous muscle Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Ophthalmology Ornithine - metabolism Other metabolic disorders Phosphorus Isotopes Retinopathies
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