Renal hemodynamic changes during smoking: effects of adrenoreceptor blockade
Background Cigarette smoking accelerates progression of renal failure in diabetic and nondiabetic renal disease. Renal hemodynamics during smoking are characterised by a reversible decrease in glomerular filtration rate (GFR) and filtration fraction (FF) accompanied by increased renovascular resista...
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| Veröffentlicht in: | European journal of clinical investigation 1999-12, Vol.29 (12), p.1010-1018 |
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| creator | BENCK, U CLORIUS, J. H ZUNA, I RITZ, E |
| description | Background
Cigarette smoking accelerates progression of renal failure in diabetic and nondiabetic renal disease. Renal hemodynamics during smoking are characterised by a reversible decrease in glomerular filtration rate (GFR) and filtration fraction (FF) accompanied by increased renovascular resistance (RVR), systemic blood pressure, heart rate and plasma catecholamine concentrations.
Materials and methods
To further assess the role of sympathetic overactivity we compared the effects of different pharmacological interventions on smoking‐induced changes of renal hemodynamics in occasional smokers. In a first series, placebo pretreatment plus smoking was compared to Prazosin pretreatment (3 mg) plus smoking. In a second study, placebo pretreatment plus smoking was compared to Atenolol pretreatment (50 mg) plus smoking.
Results
Basal blood pressure was significantly lower with Prazosin and Atenolol. On placebo, GFR and FF decreased significantly during smoking and RVR increased. With Prazosin pretreatment compared to placebo pretreatment no statistically significant differences for the changes of GFR, FF, RPF and RVR were seen. In contrast, with Atenolol pretreatment compared to placebo pretreatment, the smoking‐induced changes in active renin, GFR and RVR were significantly smaller.
Conclusion
It is suggested that the acute renal hemodynamic effects of smoking are mediated, at least in part, via increased sympathetic activity operating mainly through beta‐1 adrenergic mechanisms. |
| doi_str_mv | 10.1046/j.1365-2362.1999.00566.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69329500</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>47370250</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5246-70cdc7e9c25f064cbeaf3a8852174528d7ffaf332ecb87e5a5d62cd41de0af873</originalsourceid><addsrcrecordid>eNqNkF1v0zAUhi0EYmXwF1CEEHcJ_o6DuEHVvqRqSHxo3FmufbylTeLObkX77-cs1UBccXUsn-c99nkQKgiuCOby46oiTIqSMkkr0jRNhbGQsto_Q7OnxnM0w5jwkjY1PUGvUlphjBVh9CU6IVgoxrmaocU3GExX3EEf3GEwfWsLe2eGW0iF28V2uC1SH9a5firAe7DbVARfGBdhCBEsbLYhFssu2LVx8Bq98KZL8OZYT9HP87Mf88ty8fXiav5lUVpBuSxrbJ2tobFUeCy5XYLxzCglKKm5oMrV3ucbRsEuVQ3CCCepdZw4wMarmp2iD9PcTQz3O0hb3bfJQteZAcIuadkw2giMM_juH3AVdjEvnHTWRjDjrMmQmiAbQ0oRvN7EtjfxoAnWo2690qNVPVodc41-1K33Ofr2OH-37MH9FZz8ZuD9ETDJms5HM9g2_eEoVpyP__w8Yb_bDg7__b4-m1_lQ46XU7xNW9g_xU1ca1mzWuib6wutrtX3X5c3Qp-zB5mrqh4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>199103439</pqid></control><display><type>article</type><title>Renal hemodynamic changes during smoking: effects of adrenoreceptor blockade</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>BENCK, U ; CLORIUS, J. H ; ZUNA, I ; RITZ, E</creator><creatorcontrib>BENCK, U ; CLORIUS, J. H ; ZUNA, I ; RITZ, E</creatorcontrib><description>Background
Cigarette smoking accelerates progression of renal failure in diabetic and nondiabetic renal disease. Renal hemodynamics during smoking are characterised by a reversible decrease in glomerular filtration rate (GFR) and filtration fraction (FF) accompanied by increased renovascular resistance (RVR), systemic blood pressure, heart rate and plasma catecholamine concentrations.
Materials and methods
To further assess the role of sympathetic overactivity we compared the effects of different pharmacological interventions on smoking‐induced changes of renal hemodynamics in occasional smokers. In a first series, placebo pretreatment plus smoking was compared to Prazosin pretreatment (3 mg) plus smoking. In a second study, placebo pretreatment plus smoking was compared to Atenolol pretreatment (50 mg) plus smoking.
Results
Basal blood pressure was significantly lower with Prazosin and Atenolol. On placebo, GFR and FF decreased significantly during smoking and RVR increased. With Prazosin pretreatment compared to placebo pretreatment no statistically significant differences for the changes of GFR, FF, RPF and RVR were seen. In contrast, with Atenolol pretreatment compared to placebo pretreatment, the smoking‐induced changes in active renin, GFR and RVR were significantly smaller.
Conclusion
It is suggested that the acute renal hemodynamic effects of smoking are mediated, at least in part, via increased sympathetic activity operating mainly through beta‐1 adrenergic mechanisms.</description><identifier>ISSN: 0014-2972</identifier><identifier>EISSN: 1365-2362</identifier><identifier>DOI: 10.1046/j.1365-2362.1999.00566.x</identifier><identifier>PMID: 10583448</identifier><language>eng</language><publisher>Oxford BSL: Blackwell Science Ltd</publisher><subject>Adrenergic alpha-Antagonists - pharmacology ; Adrenergic beta-Antagonists - pharmacology ; Adult ; Antihypertensive Agents - pharmacology ; Atenolol - pharmacology ; Biological and medical sciences ; Blood Pressure - drug effects ; Catecholamines ; Cohort Studies ; Female ; Glomerular Filtration Rate - drug effects ; glomerular function ; Heart Rate - drug effects ; Hemodynamics - drug effects ; Humans ; Kidney - physiopathology ; Kidneys ; Male ; Medical sciences ; Nephrology. Urinary tract diseases ; Norepinephrine - blood ; Prazosin - pharmacology ; Renal Circulation ; renal hemodynamics ; renin ; Renin - blood ; smoking ; Smoking - adverse effects ; Smoking - physiopathology ; sympathetic activation ; Tobacco, tobacco smoking ; Toxicology ; Urinary system involvement in other diseases. Miscellaneous</subject><ispartof>European journal of clinical investigation, 1999-12, Vol.29 (12), p.1010-1018</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Dec 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5246-70cdc7e9c25f064cbeaf3a8852174528d7ffaf332ecb87e5a5d62cd41de0af873</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2362.1999.00566.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2362.1999.00566.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1208440$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10583448$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BENCK, U</creatorcontrib><creatorcontrib>CLORIUS, J. H</creatorcontrib><creatorcontrib>ZUNA, I</creatorcontrib><creatorcontrib>RITZ, E</creatorcontrib><title>Renal hemodynamic changes during smoking: effects of adrenoreceptor blockade</title><title>European journal of clinical investigation</title><addtitle>European Journal of Clinical Investigation</addtitle><description>Background
Cigarette smoking accelerates progression of renal failure in diabetic and nondiabetic renal disease. Renal hemodynamics during smoking are characterised by a reversible decrease in glomerular filtration rate (GFR) and filtration fraction (FF) accompanied by increased renovascular resistance (RVR), systemic blood pressure, heart rate and plasma catecholamine concentrations.
Materials and methods
To further assess the role of sympathetic overactivity we compared the effects of different pharmacological interventions on smoking‐induced changes of renal hemodynamics in occasional smokers. In a first series, placebo pretreatment plus smoking was compared to Prazosin pretreatment (3 mg) plus smoking. In a second study, placebo pretreatment plus smoking was compared to Atenolol pretreatment (50 mg) plus smoking.
Results
Basal blood pressure was significantly lower with Prazosin and Atenolol. On placebo, GFR and FF decreased significantly during smoking and RVR increased. With Prazosin pretreatment compared to placebo pretreatment no statistically significant differences for the changes of GFR, FF, RPF and RVR were seen. In contrast, with Atenolol pretreatment compared to placebo pretreatment, the smoking‐induced changes in active renin, GFR and RVR were significantly smaller.
Conclusion
It is suggested that the acute renal hemodynamic effects of smoking are mediated, at least in part, via increased sympathetic activity operating mainly through beta‐1 adrenergic mechanisms.</description><subject>Adrenergic alpha-Antagonists - pharmacology</subject><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Adult</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Atenolol - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Catecholamines</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Glomerular Filtration Rate - drug effects</subject><subject>glomerular function</subject><subject>Heart Rate - drug effects</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Kidney - physiopathology</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Norepinephrine - blood</subject><subject>Prazosin - pharmacology</subject><subject>Renal Circulation</subject><subject>renal hemodynamics</subject><subject>renin</subject><subject>Renin - blood</subject><subject>smoking</subject><subject>Smoking - adverse effects</subject><subject>Smoking - physiopathology</subject><subject>sympathetic activation</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><issn>0014-2972</issn><issn>1365-2362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1v0zAUhi0EYmXwF1CEEHcJ_o6DuEHVvqRqSHxo3FmufbylTeLObkX77-cs1UBccXUsn-c99nkQKgiuCOby46oiTIqSMkkr0jRNhbGQsto_Q7OnxnM0w5jwkjY1PUGvUlphjBVh9CU6IVgoxrmaocU3GExX3EEf3GEwfWsLe2eGW0iF28V2uC1SH9a5firAe7DbVARfGBdhCBEsbLYhFssu2LVx8Bq98KZL8OZYT9HP87Mf88ty8fXiav5lUVpBuSxrbJ2tobFUeCy5XYLxzCglKKm5oMrV3ucbRsEuVQ3CCCepdZw4wMarmp2iD9PcTQz3O0hb3bfJQteZAcIuadkw2giMM_juH3AVdjEvnHTWRjDjrMmQmiAbQ0oRvN7EtjfxoAnWo2690qNVPVodc41-1K33Ofr2OH-37MH9FZz8ZuD9ETDJms5HM9g2_eEoVpyP__w8Yb_bDg7__b4-m1_lQ46XU7xNW9g_xU1ca1mzWuib6wutrtX3X5c3Qp-zB5mrqh4</recordid><startdate>199912</startdate><enddate>199912</enddate><creator>BENCK, U</creator><creator>CLORIUS, J. H</creator><creator>ZUNA, I</creator><creator>RITZ, E</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>199912</creationdate><title>Renal hemodynamic changes during smoking: effects of adrenoreceptor blockade</title><author>BENCK, U ; CLORIUS, J. H ; ZUNA, I ; RITZ, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5246-70cdc7e9c25f064cbeaf3a8852174528d7ffaf332ecb87e5a5d62cd41de0af873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adrenergic alpha-Antagonists - pharmacology</topic><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Adult</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Atenolol - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Catecholamines</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Glomerular Filtration Rate - drug effects</topic><topic>glomerular function</topic><topic>Heart Rate - drug effects</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Kidney - physiopathology</topic><topic>Kidneys</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Norepinephrine - blood</topic><topic>Prazosin - pharmacology</topic><topic>Renal Circulation</topic><topic>renal hemodynamics</topic><topic>renin</topic><topic>Renin - blood</topic><topic>smoking</topic><topic>Smoking - adverse effects</topic><topic>Smoking - physiopathology</topic><topic>sympathetic activation</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BENCK, U</creatorcontrib><creatorcontrib>CLORIUS, J. H</creatorcontrib><creatorcontrib>ZUNA, I</creatorcontrib><creatorcontrib>RITZ, E</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BENCK, U</au><au>CLORIUS, J. H</au><au>ZUNA, I</au><au>RITZ, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal hemodynamic changes during smoking: effects of adrenoreceptor blockade</atitle><jtitle>European journal of clinical investigation</jtitle><addtitle>European Journal of Clinical Investigation</addtitle><date>1999-12</date><risdate>1999</risdate><volume>29</volume><issue>12</issue><spage>1010</spage><epage>1018</epage><pages>1010-1018</pages><issn>0014-2972</issn><eissn>1365-2362</eissn><abstract>Background
Cigarette smoking accelerates progression of renal failure in diabetic and nondiabetic renal disease. Renal hemodynamics during smoking are characterised by a reversible decrease in glomerular filtration rate (GFR) and filtration fraction (FF) accompanied by increased renovascular resistance (RVR), systemic blood pressure, heart rate and plasma catecholamine concentrations.
Materials and methods
To further assess the role of sympathetic overactivity we compared the effects of different pharmacological interventions on smoking‐induced changes of renal hemodynamics in occasional smokers. In a first series, placebo pretreatment plus smoking was compared to Prazosin pretreatment (3 mg) plus smoking. In a second study, placebo pretreatment plus smoking was compared to Atenolol pretreatment (50 mg) plus smoking.
Results
Basal blood pressure was significantly lower with Prazosin and Atenolol. On placebo, GFR and FF decreased significantly during smoking and RVR increased. With Prazosin pretreatment compared to placebo pretreatment no statistically significant differences for the changes of GFR, FF, RPF and RVR were seen. In contrast, with Atenolol pretreatment compared to placebo pretreatment, the smoking‐induced changes in active renin, GFR and RVR were significantly smaller.
Conclusion
It is suggested that the acute renal hemodynamic effects of smoking are mediated, at least in part, via increased sympathetic activity operating mainly through beta‐1 adrenergic mechanisms.</abstract><cop>Oxford BSL</cop><pub>Blackwell Science Ltd</pub><pmid>10583448</pmid><doi>10.1046/j.1365-2362.1999.00566.x</doi><tpages>9</tpages></addata></record> |
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| ispartof | European journal of clinical investigation, 1999-12, Vol.29 (12), p.1010-1018 |
| issn | 0014-2972 1365-2362 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Adrenergic alpha-Antagonists - pharmacology Adrenergic beta-Antagonists - pharmacology Adult Antihypertensive Agents - pharmacology Atenolol - pharmacology Biological and medical sciences Blood Pressure - drug effects Catecholamines Cohort Studies Female Glomerular Filtration Rate - drug effects glomerular function Heart Rate - drug effects Hemodynamics - drug effects Humans Kidney - physiopathology Kidneys Male Medical sciences Nephrology. Urinary tract diseases Norepinephrine - blood Prazosin - pharmacology Renal Circulation renal hemodynamics renin Renin - blood smoking Smoking - adverse effects Smoking - physiopathology sympathetic activation Tobacco, tobacco smoking Toxicology Urinary system involvement in other diseases. Miscellaneous |
| title | Renal hemodynamic changes during smoking: effects of adrenoreceptor blockade |
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