Expression of cytokine genes and increased nuclear factor-kappa B activity in the brains of scrapie-infected mice

A number of aspects of the pathogenesis of scrapie remain to be elucidated. The cellular and molecular aspects of the neuropathology in scrapie suggest the possibility that the proinflammatory cytokines could act as pathogenic mediators in this neurodegenerative disease. To understand this possibili...

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Veröffentlicht in:	Brain research. Molecular brain research. 1999-11, Vol.73 (1), p.17-27
Hauptverfasser:	Kim, Jae-Il, Ju, Won-Kyu, Choi, Jin-Ho, Kim, Jin, Choi, Eun-Kyoung, Carp, Richard I, Wisniewski, Henryk M, Kim, Yong-Sun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocyte Biological and medical sciences Brain - metabolism Brain - pathology Cytokine Cytokines - genetics Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Electrophoresis, Polyacrylamide Gel Gene Expression Regulation Immunohistochemistry Inflammation Mediators - metabolism Interleukin-1 - genetics Interleukin-6 - genetics Lymphotoxin-alpha - genetics Male Medical sciences Mice Neurology NF-kappa B - analysis NF-kappa B - metabolism NF-κB Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type II Prion Reactive oxygen species Reactive Oxygen Species - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Scrapie Scrapie - metabolism Tumor Necrosis Factor-alpha - genetics
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