The Effects of Fentanyl-Like Opioids and Hydromorphone on Human 5-HT3A Receptors

5-HT(3) receptors are involved in various physiologic functions, including the modulation of emesis. 5-HT(3) antagonists are clinically widely used as potent antiemetics. Emesis is also a side effect of opioid analgesics. Intriguingly, the natural opioid morphine shows specific interactions with hum...

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Veröffentlicht in:	Anesthesia and analgesia 2008-07, Vol.107 (1), p.107-112
Hauptverfasser:	Wittmann, Maria, Schaaf, Thomas, Peters, Ineke, Wirz, Stefan, Urban, Bernd W., Barann, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - pharmacology Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antiemetics - pharmacology Biological and medical sciences Cells, Cultured Dose-Response Relationship, Drug Fentanyl - pharmacology Humans Hydromorphone - pharmacology Medical sciences Morphine - pharmacology Receptors, Serotonin, 5-HT3 - drug effects Receptors, Serotonin, 5-HT3 - physiology Serotonin 5-HT3 Receptor Antagonists Serotonin Antagonists - pharmacology
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