APOE-epsilon4 polymorphism and cognitive deficit among the elderly population of Fernando de Noronha
Polymorphism of the gene for apolipoprotein E (APOE) is an important risk factor for the development of Alzheimer's disease. The epsilon4 allele of the APOE gene has been linked with a number of neuropsychiatric illnesses, and also with stress and depression among geriatric populations. To iden...
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| Veröffentlicht in: | Arquivos de neuro-psiquiatria 2008-06, Vol.66 (2B), p.298-302 |
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| creator | Garcia, Anália Nusya Silva, Helker Albuquerque da Silva, Renan Carlos Leal, Eliane Maria Medeiros Rodrigues, Lorena Silva, Vanessa Cavalcante da Dellalibera, Edileine Freitas, Elizabete Malaquias Ataíde, Jr, Luiz Muniz, Maria Tereza Cartaxo |
| description | Polymorphism of the gene for apolipoprotein E (APOE) is an important risk factor for the development of Alzheimer's disease. The epsilon4 allele of the APOE gene has been linked with a number of neuropsychiatric illnesses, and also with stress and depression among geriatric populations.
To identify APOE-epsilon4 polymorphism and correlate this with cognitive deficit among the elderly population of the island of Fernando de Noronha.
Neuropsychiatric tests (mini-mental state examination, verbal fluency test and clock drawing test) were applied to 52 elderly people without Alzheimer's disease. DNA was isolated from peripheral blood and genotyping of APOE was done by the PCR-RFLP method.
87% of the elderly population (mean age 69.6+/-7.0) had cognitive deficit.
The observed frequency of the epsilon4 allele was 10%, but the correlation between the presence of epsilon4 and cognitive deficit in this population was not statistically significant. |
| format | Article |
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To identify APOE-epsilon4 polymorphism and correlate this with cognitive deficit among the elderly population of the island of Fernando de Noronha.
Neuropsychiatric tests (mini-mental state examination, verbal fluency test and clock drawing test) were applied to 52 elderly people without Alzheimer's disease. DNA was isolated from peripheral blood and genotyping of APOE was done by the PCR-RFLP method.
87% of the elderly population (mean age 69.6+/-7.0) had cognitive deficit.
The observed frequency of the epsilon4 allele was 10%, but the correlation between the presence of epsilon4 and cognitive deficit in this population was not statistically significant.</description><identifier>ISSN: 0004-282X</identifier><identifier>PMID: 18641859</identifier><language>eng</language><publisher>Brazil</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Alleles ; Alzheimer Disease - diagnosis ; Alzheimer Disease - genetics ; Analysis of Variance ; Apolipoprotein E4 - genetics ; Brazil - epidemiology ; Brief Psychiatric Rating Scale ; Chi-Square Distribution ; Cognition - physiology ; Cognition Disorders - epidemiology ; Cognition Disorders - genetics ; Cognition Disorders - psychology ; Educational Status ; Female ; Genotype ; Geriatric Assessment ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Polymorphism, Genetic ; Sex Factors</subject><ispartof>Arquivos de neuro-psiquiatria, 2008-06, Vol.66 (2B), p.298-302</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18641859$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garcia, Anália Nusya</creatorcontrib><creatorcontrib>Silva, Helker Albuquerque da</creatorcontrib><creatorcontrib>Silva, Renan Carlos</creatorcontrib><creatorcontrib>Leal, Eliane Maria Medeiros</creatorcontrib><creatorcontrib>Rodrigues, Lorena</creatorcontrib><creatorcontrib>Silva, Vanessa Cavalcante da</creatorcontrib><creatorcontrib>Dellalibera, Edileine</creatorcontrib><creatorcontrib>Freitas, Elizabete Malaquias</creatorcontrib><creatorcontrib>Ataíde, Jr, Luiz</creatorcontrib><creatorcontrib>Muniz, Maria Tereza Cartaxo</creatorcontrib><title>APOE-epsilon4 polymorphism and cognitive deficit among the elderly population of Fernando de Noronha</title><title>Arquivos de neuro-psiquiatria</title><addtitle>Arq Neuropsiquiatr</addtitle><description>Polymorphism of the gene for apolipoprotein E (APOE) is an important risk factor for the development of Alzheimer's disease. The epsilon4 allele of the APOE gene has been linked with a number of neuropsychiatric illnesses, and also with stress and depression among geriatric populations.
To identify APOE-epsilon4 polymorphism and correlate this with cognitive deficit among the elderly population of the island of Fernando de Noronha.
Neuropsychiatric tests (mini-mental state examination, verbal fluency test and clock drawing test) were applied to 52 elderly people without Alzheimer's disease. DNA was isolated from peripheral blood and genotyping of APOE was done by the PCR-RFLP method.
87% of the elderly population (mean age 69.6+/-7.0) had cognitive deficit.
The observed frequency of the epsilon4 allele was 10%, but the correlation between the presence of epsilon4 and cognitive deficit in this population was not statistically significant.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - genetics</subject><subject>Analysis of Variance</subject><subject>Apolipoprotein E4 - genetics</subject><subject>Brazil - epidemiology</subject><subject>Brief Psychiatric Rating Scale</subject><subject>Chi-Square Distribution</subject><subject>Cognition - physiology</subject><subject>Cognition Disorders - epidemiology</subject><subject>Cognition Disorders - genetics</subject><subject>Cognition Disorders - psychology</subject><subject>Educational Status</subject><subject>Female</subject><subject>Genotype</subject><subject>Geriatric Assessment</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Polymorphism, Genetic</subject><subject>Sex Factors</subject><issn>0004-282X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kL1OwzAYRT2AaCm8AvLEFsl2nB-PVdUCUkUZOrBFjv25NXJsYydIfXuCgOku51zp3iu0JITwgrXsfYFuc_4ghHEhmhu0oG3NaVuJJdLrt8O2gJitC57jGNxlCCmebR6w9BqrcPJ2tF-ANRir7IjlEPwJj2fA4DQkd5mlODk52uBxMHgHyc9mmAX8GlLwZ3mHro10Ge7_coWOu-1x81zsD08vm_W-iBUXBZNa9ISLEoyoGuCm1RVtVKMop70yvCdaCM4lUYZIQplo-4aW80RW17JveblCj7-1MYXPCfLYDTYrcE56CFPualGyuiE_4MMfOPUD6C4mO8h06f5vKb8BunFeMg</recordid><startdate>200806</startdate><enddate>200806</enddate><creator>Garcia, Anália Nusya</creator><creator>Silva, Helker Albuquerque da</creator><creator>Silva, Renan Carlos</creator><creator>Leal, Eliane Maria Medeiros</creator><creator>Rodrigues, Lorena</creator><creator>Silva, Vanessa Cavalcante da</creator><creator>Dellalibera, Edileine</creator><creator>Freitas, Elizabete Malaquias</creator><creator>Ataíde, Jr, Luiz</creator><creator>Muniz, Maria Tereza Cartaxo</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200806</creationdate><title>APOE-epsilon4 polymorphism and cognitive deficit among the elderly population of Fernando de Noronha</title><author>Garcia, Anália Nusya ; Silva, Helker Albuquerque da ; Silva, Renan Carlos ; Leal, Eliane Maria Medeiros ; Rodrigues, Lorena ; Silva, Vanessa Cavalcante da ; Dellalibera, Edileine ; Freitas, Elizabete Malaquias ; Ataíde, Jr, Luiz ; Muniz, Maria Tereza Cartaxo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p549-2ad9b0493ef957e4f8d517c7c141bcf4b0d9944a0cf0a01298b713004266ab843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alleles</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - genetics</topic><topic>Analysis of Variance</topic><topic>Apolipoprotein E4 - genetics</topic><topic>Brazil - epidemiology</topic><topic>Brief Psychiatric Rating Scale</topic><topic>Chi-Square Distribution</topic><topic>Cognition - physiology</topic><topic>Cognition Disorders - epidemiology</topic><topic>Cognition Disorders - genetics</topic><topic>Cognition Disorders - psychology</topic><topic>Educational Status</topic><topic>Female</topic><topic>Genotype</topic><topic>Geriatric Assessment</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Polymorphism, Genetic</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garcia, Anália Nusya</creatorcontrib><creatorcontrib>Silva, Helker Albuquerque da</creatorcontrib><creatorcontrib>Silva, Renan Carlos</creatorcontrib><creatorcontrib>Leal, Eliane Maria Medeiros</creatorcontrib><creatorcontrib>Rodrigues, Lorena</creatorcontrib><creatorcontrib>Silva, Vanessa Cavalcante da</creatorcontrib><creatorcontrib>Dellalibera, Edileine</creatorcontrib><creatorcontrib>Freitas, Elizabete Malaquias</creatorcontrib><creatorcontrib>Ataíde, Jr, Luiz</creatorcontrib><creatorcontrib>Muniz, Maria Tereza Cartaxo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Arquivos de neuro-psiquiatria</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia, Anália Nusya</au><au>Silva, Helker Albuquerque da</au><au>Silva, Renan Carlos</au><au>Leal, Eliane Maria Medeiros</au><au>Rodrigues, Lorena</au><au>Silva, Vanessa Cavalcante da</au><au>Dellalibera, Edileine</au><au>Freitas, Elizabete Malaquias</au><au>Ataíde, Jr, Luiz</au><au>Muniz, Maria Tereza Cartaxo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>APOE-epsilon4 polymorphism and cognitive deficit among the elderly population of Fernando de Noronha</atitle><jtitle>Arquivos de neuro-psiquiatria</jtitle><addtitle>Arq Neuropsiquiatr</addtitle><date>2008-06</date><risdate>2008</risdate><volume>66</volume><issue>2B</issue><spage>298</spage><epage>302</epage><pages>298-302</pages><issn>0004-282X</issn><abstract>Polymorphism of the gene for apolipoprotein E (APOE) is an important risk factor for the development of Alzheimer's disease. The epsilon4 allele of the APOE gene has been linked with a number of neuropsychiatric illnesses, and also with stress and depression among geriatric populations.
To identify APOE-epsilon4 polymorphism and correlate this with cognitive deficit among the elderly population of the island of Fernando de Noronha.
Neuropsychiatric tests (mini-mental state examination, verbal fluency test and clock drawing test) were applied to 52 elderly people without Alzheimer's disease. DNA was isolated from peripheral blood and genotyping of APOE was done by the PCR-RFLP method.
87% of the elderly population (mean age 69.6+/-7.0) had cognitive deficit.
The observed frequency of the epsilon4 allele was 10%, but the correlation between the presence of epsilon4 and cognitive deficit in this population was not statistically significant.</abstract><cop>Brazil</cop><pmid>18641859</pmid><tpages>5</tpages></addata></record> |
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| subjects | Age Factors Aged Aged, 80 and over Alleles Alzheimer Disease - diagnosis Alzheimer Disease - genetics Analysis of Variance Apolipoprotein E4 - genetics Brazil - epidemiology Brief Psychiatric Rating Scale Chi-Square Distribution Cognition - physiology Cognition Disorders - epidemiology Cognition Disorders - genetics Cognition Disorders - psychology Educational Status Female Genotype Geriatric Assessment Humans Male Middle Aged Neuropsychological Tests Polymorphism, Genetic Sex Factors |
| title | APOE-epsilon4 polymorphism and cognitive deficit among the elderly population of Fernando de Noronha |
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