Effect of long-term infection with nef-defective attenuated HIV type 1 on CD4+ and CD8+ T lymphocytes : Increased CD45RO+CD4+ T lymphocytes and limited activation of CD8+ T lymphocytes

Members of the Sydney Blood Bank Cohort (SBBC) have been infected with an attenuated strain of HIV-1 with a natural nef/LTR mutation and have maintained relatively stable CD4+ T lymphocyte counts for 14-18 years. Flow cytometric analysis was used to examine the phenotype of CD4+ and CD8+ T lymphocyt...

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Veröffentlicht in:	AIDS research and human retroviruses 1999-11, Vol.15 (17), p.1519-1527
Hauptverfasser:	ZAUNDERS, J. J, GECZY, A. F, DYER, W. B, MCINTYRE, L. B, COOLEY, M. A, ASHTON, L. J, RAYNES-GREENOW, C. H, LEARMONT, J, COOPER, D. A, SULLIVAN, J. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over AIDS/HIV Antigens, Surface - analysis Biological and medical sciences CD4-CD8 Ratio CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cohort Studies Cross-Sectional Studies Defective Viruses - genetics Defective Viruses - immunology Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Genes, nef - genetics HIV Infections - immunology HIV Infections - virology HIV-1 - genetics HIV-1 - immunology Human viral diseases Humans Infectious diseases Longitudinal Studies Lymphocyte Count Male Medical sciences Microbiology Middle Aged Polymerase Chain Reaction Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains RNA, Viral - blood Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology
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