Codelivery of PEG-IFN-α inhibits HCV DNA vaccine-induced T cell responses but not humoral responses in African green monkeys

Abstract Although pegylated interferon alpha (PEG-IFN-α) with ribavirin treatment constitutes an effective means of treatment for chronic hepatitis C, novel approaches are needed due to the inefficient effects of the current therapy against chronic infection with genotype 1 virus. In this study, the...

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Veröffentlicht in:	Vaccine 2008-07, Vol.26 (32), p.3978-3983
Hauptverfasser:	Park, Su-Hyung, Lee, Sang Rae, Hyun, Byung Hwa, Kim, Byong-Moon, Sung, Young Chul
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibody Formation - immunology Cercopithecus aethiops - immunology DNA vaccine HCV Hepacivirus - immunology Hepatitis C - immunology Hepatitis C - prevention & control Hepatitis C virus Interferon-alpha - administration & dosage Interferon-alpha - immunology Interferon-alpha - pharmacology PEG-IFN-α T cell response T-Lymphocytes - drug effects T-Lymphocytes - immunology Vaccines, DNA - administration & dosage Vaccines, DNA - pharmacology Viral Hepatitis Vaccines - immunology
Online-Zugang:	Volltext
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