Functional electrical stimulation exercise increases GLUT-1 and GLUT-4 in paralyzed skeletal muscle
The study purpose was to determine the effect of functional electrical stimulation (FES)-leg cycle ergometer training (30 minutes on 3 d/wk for 8 weeks) on the GLUT-1 and GLUT-4 content of paralyzed skeletal muscle. Biopsy samples of vastus lateralis muscle were obtained pre- and post-training from...
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| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 1999-11, Vol.48 (11), p.1409-1413 |
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| container_title | Metabolism, clinical and experimental |
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| creator | Chilibeck, Philip D. Bell, Gordon Jeon, Justin Weiss, Christina B. Murdoch, Gordon MacLean, Ian Ryan, Edmond Burnham, Robert |
| description | The study purpose was to determine the effect of functional electrical stimulation (FES)-leg cycle ergometer training (30 minutes on 3 d/wk for 8 weeks) on the GLUT-1 and GLUT-4 content of paralyzed skeletal muscle. Biopsy samples of vastus lateralis muscle were obtained pre- and post-training from five individuals with motor-complete spinal cord injury ([SCI] four men and one woman aged 31 to 50 years, 3 to 25 years postinjury involving C5-T8. Western in blot analysis indicated that GLUT-1 increased by 52% and GLUT-4 increased by 72% with training (
P < .05). This coincided with an increase in the muscle oxidative capacity as indicated by a 56% increase in citrate synthase (CS) activity (
P < .05) and an improvement in the insulin sensitivity index as determined from oral glucose tolerance tests (
P < .05). It is concluded that FES endurance training is effective to increase glucose transporter protein levels in paralyzed skeletal muscle of individuals with SCI. |
| doi_str_mv | 10.1016/S0026-0495(99)90151-8 |
| format | Article |
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P < .05). This coincided with an increase in the muscle oxidative capacity as indicated by a 56% increase in citrate synthase (CS) activity (
P < .05) and an improvement in the insulin sensitivity index as determined from oral glucose tolerance tests (
P < .05). It is concluded that FES endurance training is effective to increase glucose transporter protein levels in paralyzed skeletal muscle of individuals with SCI.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/S0026-0495(99)90151-8</identifier><identifier>PMID: 10582549</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Biopsy ; Blotting, Western ; Citrate (si)-Synthase - metabolism ; Diseases of the nervous system ; Electric Stimulation Therapy ; Exercise Therapy ; Female ; Glucose Tolerance Test ; Glucose Transporter Type 1 ; Glucose Transporter Type 4 ; Humans ; Male ; Medical sciences ; Middle Aged ; Monosaccharide Transport Proteins - metabolism ; Muscle Proteins ; Muscle, Skeletal - enzymology ; Muscle, Skeletal - metabolism ; Oxidation-Reduction ; Paralysis - enzymology ; Paralysis - metabolism ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><ispartof>Metabolism, clinical and experimental, 1999-11, Vol.48 (11), p.1409-1413</ispartof><rights>1999</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-7140a67a4307cc2d688df81e60b122abb9b3600fd642491237454a0e98f42e513</citedby><cites>FETCH-LOGICAL-c456t-7140a67a4307cc2d688df81e60b122abb9b3600fd642491237454a0e98f42e513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0026049599901518$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1192540$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10582549$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chilibeck, Philip D.</creatorcontrib><creatorcontrib>Bell, Gordon</creatorcontrib><creatorcontrib>Jeon, Justin</creatorcontrib><creatorcontrib>Weiss, Christina B.</creatorcontrib><creatorcontrib>Murdoch, Gordon</creatorcontrib><creatorcontrib>MacLean, Ian</creatorcontrib><creatorcontrib>Ryan, Edmond</creatorcontrib><creatorcontrib>Burnham, Robert</creatorcontrib><title>Functional electrical stimulation exercise increases GLUT-1 and GLUT-4 in paralyzed skeletal muscle</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>The study purpose was to determine the effect of functional electrical stimulation (FES)-leg cycle ergometer training (30 minutes on 3 d/wk for 8 weeks) on the GLUT-1 and GLUT-4 content of paralyzed skeletal muscle. Biopsy samples of vastus lateralis muscle were obtained pre- and post-training from five individuals with motor-complete spinal cord injury ([SCI] four men and one woman aged 31 to 50 years, 3 to 25 years postinjury involving C5-T8. Western in blot analysis indicated that GLUT-1 increased by 52% and GLUT-4 increased by 72% with training (
P < .05). This coincided with an increase in the muscle oxidative capacity as indicated by a 56% increase in citrate synthase (CS) activity (
P < .05) and an improvement in the insulin sensitivity index as determined from oral glucose tolerance tests (
P < .05). It is concluded that FES endurance training is effective to increase glucose transporter protein levels in paralyzed skeletal muscle of individuals with SCI.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Blotting, Western</subject><subject>Citrate (si)-Synthase - metabolism</subject><subject>Diseases of the nervous system</subject><subject>Electric Stimulation Therapy</subject><subject>Exercise Therapy</subject><subject>Female</subject><subject>Glucose Tolerance Test</subject><subject>Glucose Transporter Type 1</subject><subject>Glucose Transporter Type 4</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Monosaccharide Transport Proteins - metabolism</subject><subject>Muscle Proteins</subject><subject>Muscle, Skeletal - enzymology</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Oxidation-Reduction</subject><subject>Paralysis - enzymology</subject><subject>Paralysis - metabolism</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chilibeck, Philip D.</creatorcontrib><creatorcontrib>Bell, Gordon</creatorcontrib><creatorcontrib>Jeon, Justin</creatorcontrib><creatorcontrib>Weiss, Christina B.</creatorcontrib><creatorcontrib>Murdoch, Gordon</creatorcontrib><creatorcontrib>MacLean, Ian</creatorcontrib><creatorcontrib>Ryan, Edmond</creatorcontrib><creatorcontrib>Burnham, Robert</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chilibeck, Philip D.</au><au>Bell, Gordon</au><au>Jeon, Justin</au><au>Weiss, Christina B.</au><au>Murdoch, Gordon</au><au>MacLean, Ian</au><au>Ryan, Edmond</au><au>Burnham, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional electrical stimulation exercise increases GLUT-1 and GLUT-4 in paralyzed skeletal muscle</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>48</volume><issue>11</issue><spage>1409</spage><epage>1413</epage><pages>1409-1413</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>The study purpose was to determine the effect of functional electrical stimulation (FES)-leg cycle ergometer training (30 minutes on 3 d/wk for 8 weeks) on the GLUT-1 and GLUT-4 content of paralyzed skeletal muscle. Biopsy samples of vastus lateralis muscle were obtained pre- and post-training from five individuals with motor-complete spinal cord injury ([SCI] four men and one woman aged 31 to 50 years, 3 to 25 years postinjury involving C5-T8. Western in blot analysis indicated that GLUT-1 increased by 52% and GLUT-4 increased by 72% with training (
P < .05). This coincided with an increase in the muscle oxidative capacity as indicated by a 56% increase in citrate synthase (CS) activity (
P < .05) and an improvement in the insulin sensitivity index as determined from oral glucose tolerance tests (
P < .05). It is concluded that FES endurance training is effective to increase glucose transporter protein levels in paralyzed skeletal muscle of individuals with SCI.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10582549</pmid><doi>10.1016/S0026-0495(99)90151-8</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Biopsy Blotting, Western Citrate (si)-Synthase - metabolism Diseases of the nervous system Electric Stimulation Therapy Exercise Therapy Female Glucose Tolerance Test Glucose Transporter Type 1 Glucose Transporter Type 4 Humans Male Medical sciences Middle Aged Monosaccharide Transport Proteins - metabolism Muscle Proteins Muscle, Skeletal - enzymology Muscle, Skeletal - metabolism Oxidation-Reduction Paralysis - enzymology Paralysis - metabolism Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) |
| title | Functional electrical stimulation exercise increases GLUT-1 and GLUT-4 in paralyzed skeletal muscle |
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