Novel PVA-Based Hydrogel Microparticles for Doxorubicin Delivery
Micro- and nanoparticles are considered suitable drug delivery systems for their unique features, such as a large surface to volume ratio, and for the possibility to tune their size and hydrophobicity. A polymer/polymer/water emulsion method was used for producing a chemically cross-linked hydrogel...
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| Veröffentlicht in: | Biomacromolecules 2008-07, Vol.9 (7), p.1967-1973 |
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| container_end_page | 1973 |
|---|---|
| container_issue | 7 |
| container_start_page | 1967 |
| container_title | Biomacromolecules |
| container_volume | 9 |
| creator | Cavalieri, Francesca Chiessi, Ester Villa, Raffaella Viganò, Lucia Zaffaroni, Nadia Telling, Mark F Paradossi, Gaio |
| description | Micro- and nanoparticles are considered suitable drug delivery systems for their unique features, such as a large surface to volume ratio, and for the possibility to tune their size and hydrophobicity. A polymer/polymer/water emulsion method was used for producing a chemically cross-linked hydrogel made of poly(vinyl alcohol) and of poly(methacrylate) moieties. Mesoscopic investigation of the microparticles was accomplished by laser scanning confocal microscopy. Dynamics of confined water within the gel meshes was studied by quasi-elastic incoherent neutron scattering. Succinoylation of these particles allowed an efficient loading with a maximum doxorubicin payload of about 50% (w/w) of dry microparticles. To evaluate the potentials of such a microdevice for drug delivery, LoVo colon cancer cells have been exposed to doxorubicin loaded microparticles to study the in vitro efficiency of the payload release and the consequent cytotoxic effect. |
| doi_str_mv | 10.1021/bm800225v |
| format | Article |
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A polymer/polymer/water emulsion method was used for producing a chemically cross-linked hydrogel made of poly(vinyl alcohol) and of poly(methacrylate) moieties. Mesoscopic investigation of the microparticles was accomplished by laser scanning confocal microscopy. Dynamics of confined water within the gel meshes was studied by quasi-elastic incoherent neutron scattering. Succinoylation of these particles allowed an efficient loading with a maximum doxorubicin payload of about 50% (w/w) of dry microparticles. To evaluate the potentials of such a microdevice for drug delivery, LoVo colon cancer cells have been exposed to doxorubicin loaded microparticles to study the in vitro efficiency of the payload release and the consequent cytotoxic effect.</description><identifier>ISSN: 1525-7797</identifier><identifier>EISSN: 1526-4602</identifier><identifier>DOI: 10.1021/bm800225v</identifier><identifier>PMID: 18533701</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Applied sciences ; Biological and medical sciences ; Cell Line, Tumor ; Cell Survival - drug effects ; Colonic Neoplasms - drug therapy ; Colonic Neoplasms - pathology ; Doxorubicin - administration & dosage ; Drug Delivery Systems - methods ; Exact sciences and technology ; General pharmacology ; Humans ; Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage ; Medical sciences ; Microspheres ; Organic polymers ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. 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A polymer/polymer/water emulsion method was used for producing a chemically cross-linked hydrogel made of poly(vinyl alcohol) and of poly(methacrylate) moieties. Mesoscopic investigation of the microparticles was accomplished by laser scanning confocal microscopy. Dynamics of confined water within the gel meshes was studied by quasi-elastic incoherent neutron scattering. Succinoylation of these particles allowed an efficient loading with a maximum doxorubicin payload of about 50% (w/w) of dry microparticles. To evaluate the potentials of such a microdevice for drug delivery, LoVo colon cancer cells have been exposed to doxorubicin loaded microparticles to study the in vitro efficiency of the payload release and the consequent cytotoxic effect.</description><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>Colonic Neoplasms - drug therapy</subject><subject>Colonic Neoplasms - pathology</subject><subject>Doxorubicin - administration & dosage</subject><subject>Drug Delivery Systems - methods</subject><subject>Exact sciences and technology</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage</subject><subject>Medical sciences</subject><subject>Microspheres</subject><subject>Organic polymers</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemistry of polymers</subject><subject>Polymethacrylic Acids</subject><subject>Polyvinyl Alcohol</subject><subject>Properties and characterization</subject><subject>Solution and gel properties</subject><issn>1525-7797</issn><issn>1526-4602</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0DtPwzAQB3ALgSgUBr4AygISQ8CPOI43SgsUqTwGYI0cP5CrpC52U9Fvj6FRuyAx3en0053uD8AJgpcIYnRVNQWEGNPlDjhAFOdplkO8-9vTlDHOeuAwhCmEkJOM7oMeKighDKIDcP3klrpOXt4H6Y0IWiXjlfLuI44erfRuLvzCylqHxDifjNyX821lpZ0lI13bpfarI7BnRB30cVf74O3u9nU4TifP9w_DwSQVhGWLlOdMMZkRbghGNIeIKCTiAJIsLwykmjNmtDaUqgopJAtSGaUMo1gbrBUmfXC-3jv37rPVYVE2Nkhd12KmXRvKnBNMMGf_QgyLHBLCI7xYw_hnCF6bcu5tI_yqRLD8ybXc5Brtabe0rRqttrILMoKzDoggRW28mEkbNi4ejarItk7IUE5d62cxtD8OfgNu-4qT</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Cavalieri, Francesca</creator><creator>Chiessi, Ester</creator><creator>Villa, Raffaella</creator><creator>Viganò, Lucia</creator><creator>Zaffaroni, Nadia</creator><creator>Telling, Mark F</creator><creator>Paradossi, Gaio</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080701</creationdate><title>Novel PVA-Based Hydrogel Microparticles for Doxorubicin Delivery</title><author>Cavalieri, Francesca ; Chiessi, Ester ; Villa, Raffaella ; Viganò, Lucia ; Zaffaroni, Nadia ; Telling, Mark F ; Paradossi, Gaio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a374t-967d7c439f32156013d1a7c403468f05e977feef55db1d1c83bfddf752ef2ed23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>Colonic Neoplasms - drug therapy</topic><topic>Colonic Neoplasms - pathology</topic><topic>Doxorubicin - administration & dosage</topic><topic>Drug Delivery Systems - methods</topic><topic>Exact sciences and technology</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage</topic><topic>Medical sciences</topic><topic>Microspheres</topic><topic>Organic polymers</topic><topic>Pharmaceutical technology. 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| fulltext | fulltext |
| identifier | ISSN: 1525-7797 |
| ispartof | Biomacromolecules, 2008-07, Vol.9 (7), p.1967-1973 |
| issn | 1525-7797 1526-4602 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Applied sciences Biological and medical sciences Cell Line, Tumor Cell Survival - drug effects Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Doxorubicin - administration & dosage Drug Delivery Systems - methods Exact sciences and technology General pharmacology Humans Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage Medical sciences Microspheres Organic polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Polymethacrylic Acids Polyvinyl Alcohol Properties and characterization Solution and gel properties |
| title | Novel PVA-Based Hydrogel Microparticles for Doxorubicin Delivery |
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